Elo Madissoon
YOU?
Author Swipe
View article: Histology and spatial transcriptomic integration revealed infiltration zone with specific cell composition as a prognostic hotspot in glioblastoma
Histology and spatial transcriptomic integration revealed infiltration zone with specific cell composition as a prognostic hotspot in glioblastoma Open
Background Glioblastoma (GBM), the most aggressive primary brain tumor, has a median survival of approximately 15 months. Twenty percent of patients survive beyond three years, but known clinical factors like age, performance status, resec…
View article: An organotypic atlas of human vascular cells
An organotypic atlas of human vascular cells Open
The human vascular system, comprising endothelial cells (ECs) and mural cells, covers a vast surface area in the body, providing a critical interface between blood and tissue environments. Functional differences exist across specific vascu…
View article: Transcriptome Analysis of Archived Tumor Tissues by Visium, GeoMx DSP, and Chromium Methods Reveals Inter- and Intra-Patient Heterogeneity
Transcriptome Analysis of Archived Tumor Tissues by Visium, GeoMx DSP, and Chromium Methods Reveals Inter- and Intra-Patient Heterogeneity Open
Recent advancements in probe-based, full-transcriptome, high-resolution technologies for Formalin-Fixed Paraffin-Embedded (FFPE) tissues, such as Visium CytAssist, Chromium Flex (10X Genomics), and GeoMx DSP (Nanostring), have opened new o…
View article: An integrated cell atlas of the lung in health and disease
An integrated cell atlas of the lung in health and disease Open
View article: A spatially resolved atlas of the human lung characterizes a gland-associated immune niche
A spatially resolved atlas of the human lung characterizes a gland-associated immune niche Open
View article: A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates
A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates Open
We present a multiomic cell atlas of human lung development that combines single-cell RNA and ATAC sequencing, high-throughput spatial transcriptomics, and single-cell imaging. Coupling single-cell methods with spatial analysis has allowed…
View article: A spatial multi-omics atlas of the human lung reveals a novel gland-associated immune niche
A spatial multi-omics atlas of the human lung reveals a novel gland-associated immune niche Open
To (re)define tissue architecture of the lung and airways at the cellular and molecular level, we profiled five proximal-to-distal locations of healthy human lungs in depth using multi-omic single cell/nuclei and Visium Spatial Transcripto…
View article: An integrated cell atlas of the human lung in health and disease
An integrated cell atlas of the human lung in health and disease Open
Organ- and body-scale cell atlases have the potential to transform our understanding of human biology. To capture the variability present in the population, these atlases must include diverse demographics such as age and ethnicity from bot…
View article: An integrated cell atlas of the human lung in health and disease
An integrated cell atlas of the human lung in health and disease Open
Organ- and body-scale cell atlases have the potential to transform our understanding of human biology. To capture the variability present in the population, these atlases must include diverse demographics such as age and ethnicity from bot…
View article: A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates
A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates Open
We present a multiomic cell atlas of human lung development that combines single cell RNA and ATAC sequencing, high throughput spatial transcriptomics and single cell imaging. Coupling single cell methods with spatial analysis has allowed …
View article: Local and systemic responses to SARS-CoV-2 infection in children and adults
Local and systemic responses to SARS-CoV-2 infection in children and adults Open
View article: SARS-CoV-2 Omicron spike mediated immune escape and tropism shift
SARS-CoV-2 Omicron spike mediated immune escape and tropism shift Open
The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and is characterised by multiple spike mutations across all spike domains. Here we show that Omicron BA.1 has higher affinity for ACE2 compared to Delta, and confers very significant…
View article: A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche
A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche Open
Summary Multiple distinct cell types of the human lung and airways have been defined by single cell RNA sequencing (scRNAseq). Here we present a multi-omics spatial lung atlas to define novel cell types which we map back into the macro- an…
View article: T1 The local and systemic response to SARS-CoV-2 infection in children and adults
T1 The local and systemic response to SARS-CoV-2 infection in children and adults Open
Introduction and Objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Whilst a substantial proportion of adults infected with SARS-CoV-2 progre…
View article: The local and systemic response to SARS-CoV-2 infection in children and adults
The local and systemic response to SARS-CoV-2 infection in children and adults Open
While a substantial proportion of adults infected with SARS-CoV-2 progress to develop severe disease, children rarely manifest respiratory complications. Therefore, understanding differences in the local and systemic response to SARS-CoV-2…
View article: Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics Open
Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral tropism and impact a…
View article: Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells Open
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue pathology. Cell membrane bound angiotensin-converting enzyme 2…
View article: MOESM6 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
MOESM6 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation Open
Additional file 6: Table S5. Changes in cell-type proportions between time points and donors.
View article: MOESM5 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
MOESM5 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation Open
Additional file 5: Table S4. Differential Expression between the bulk and single-cell pseudo-bulk RNA-sequencing samples.
View article: MOESM4 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
MOESM4 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation Open
Additional file 4: Table S3. RIN-values for samples.
View article: MOESM8 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
MOESM8 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation Open
Additional file 8: Table S7. Explained variability by time in different cell types.
View article: MOESM7 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
MOESM7 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation Open
Additional file 7: Table S6. Pairwise Differential Expression between time points with bulk RNA-sequencing data in three tissues.
View article: MOESM2 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
MOESM2 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation Open
Additional file 2: Table S1. Patient characteristics and sample information.
View article: MOESM3 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
MOESM3 of scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation Open
Additional file 3: Table S2. Number of cells per cell types.
View article: scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation Open
View article: Studying immune to non-immune cell cross-talk using single-cell technologies
Studying immune to non-immune cell cross-talk using single-cell technologies Open
View article: Lung, spleen and oesophagus tissue remains stable for scRNAseq in cold preservation
Lung, spleen and oesophagus tissue remains stable for scRNAseq in cold preservation Open
Background The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single cell RNA sequencing can generate high quality data for the delivery of such an atlas. However, delays between fre…
View article: Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development
Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development Open
View article: Single-cell transcriptomes of fluorescent, ubiquitination-based cell cycle indicator cells
Single-cell transcriptomes of fluorescent, ubiquitination-based cell cycle indicator cells Open
We used a transgenic HeLa cell line that reports cell cycle phases through fluorescent, ubiquitination-based cell cycle indicators (Fucci), to produce a reference dataset of more than 270 curated single cells. Microscopic images were taken…
View article: Correction: Corrigendum: Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos
Correction: Corrigendum: Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos Open
Scientific Reports 6: Article number: 28995; published online: 14 July 2016; updated: 02 September 2016 The original version of this Article contained a typographical error in the spelling of the author Sophie Petropoulos, which was incorr…