Explanipedia

The ambulatory arterial stiffness index is not a measure of arterial stiffness in childhood Open

Plamen Bokov, Elodie Surget, Chérine Benzouid, Benjamin Dudoignon, Julien Hogan , et al. · 2025

Background The ambulatory arterial stiffness index (AASI) has emerged as an ambulatory blood pressure monitoring (ABPM) measure of stiffness and is supposedly useful in younger subjects. The objective of our cross-sectional study was to ev…

Software-based analysis of T-wave morphology: identifying the electrocardiogram signature of high-risk long QT syndrome Open

Alessandra Pia Porretta, Charles Morgat, Elodie Surget, Véronique Fressart, Adrien Bloch , et al. · 2025

Aims Despite T-wave morphology abnormalities being well-known distinctive ECG features in patients with long QT syndrome (LQTS), the subjectivity of qualitative ‘eyeballing’ in T-wave characterization still hampers its integration into dia…

Distinct patterns of ventricular fibrillation onset in primary electrical diseases: insights from a retrospective multicentre registry Open

Elodie Surget, Wally Wences Mansogo, Alessandra Pia Porretta, Constance Beyler, Adrien Bloch , et al. · 2025

Aims Ventricular fibrillation (VF) initiation is influenced by the underlying arrhythmia mechanism. Long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), Brugada syndrome (BS), and idiopathic ventricular fi…

Clinical presentation and outcomes of patients with biallelic SCN5A variants: A systematic review Open

Elodie Surget, Alexis Hermida, Alice Maltret, James Marchant, Isabelle Denjoy , et al. · 2025

Patients with biallelic SCN5A variants display early-onset severe arrhythmic phenotypes with high morbidity and mortality. Improved recognition and international collaboration are essential to optimize diagnosis, management, and pre…

Making Sense of Missense: Benchmarking MutScore for Variant Interpretation in Inherited Cardiac Diseases Open

Alessandra Pia Porretta, Véronique Fressart, Elodie Surget, Charles Morgat, Adrien Bloch , et al. · 2025

Our study supports the excellent performance of MutScore in a real-life dataset of missense variants associated with the rare subset of InCDs. MutScore represents a promising application of artificial intelligence with major potential in c…

Genetic characterization of <i>KCNQ1</i> variants improves risk stratification in type 1 long QT syndrome patients Open

Charles Morgat, Véronique Fressart, Alessandra Pia Porretta, Nathalie Neyroud, A. Messali , et al. · 2024

Aims KCNQ1 mutations cause QTc prolongation increasing life-threatening arrhythmias risks. Heterozygous mutations [type 1 long QT syndrome (LQT1)] are common. Homozygous KCNQ1 mutations cause type 1 Jervell and Lange–Nielsen syndrome (JLNS…

Distinct Electrogram Features and Ventricular Arrhythmia Induction Modes Between Repolarization and Conduction Heterogeneities Open

Estelle Renard, Elodie Surget, Richard D. Walton, Cindy Michel, David Benoîst , et al. · 2024

Microstructural substrates have the most pronounced impact on electrograms, especially when combined with sodium channel blockers, whereas local action potential duration shortening does not lead to electrogram fragmentation even though it…

Inducibility of Short-Coupled Purkinje Ectopy by Pharmacological Tests in Patients With Spontaneous Short-Coupled Idiopathic Ventricular Fibrillation Open

Michel Haı̈ssaguerre, Josselin Duchâteau, Mikaël Laredo, Thomas Lavergne, Pierre Winum , et al. · 2023

Burden of Purkinje ectopies associated with sex hormone levels Open

Elodie Surget, Ndeye Rokhaya Faye, James Marchant, Ghassen Cheniti, Mélèze Hocini , et al. · 2023

Idiopathic ventricular fibrillation associated with long‐coupled Purkinje ectopy Open

Elodie Surget, Josselin Duchâteau, James Marchant, Philippe Maury, Richard D. Walton , et al. · 2023

Introduction Idiopathic ventricular fibrillation (IVF) is mainly associated with and triggered by short‐coupled (R‐on‐T) ventricular ectopics. However, little is known about the risk of VF associated with long‐coupled premature ventricular…

Caractérisation du substrat électrophysiologique et du système de Purkinje dans les morts subites cardiaques sur cœur a priori sain Open

Elodie Surget · 2022

La mort subite cardiaque est responsable d’environ 10% de la mortalité adulte en Europe et dans le monde. Dans la majorité des cas, le décès est lié à une arythmie ventriculaire par tachycardie ou fibrillation ventriculaire (FV). Les excit…

Malignant Purkinje ectopy induced by sodium channel blockers Open

William Escande, Jean‐Baptiste Gourraud, Michel Haı̈ssaguerre, Estelle Gandjbakhch, Thomas Lavergne , et al. · 2022

Long-term freedom from ventricular fibrillation despite persistent Purkinje ectopy after catheter ablation Open

Elodie Surget, Josselin Duchâteau, Thomas Lavergne, F. Daniel Ramirez, Ghassen Cheniti , et al. · 2022

Key Teaching Points•Idiopathic ventricular fibrillation (IVF) is defined by ventricular fibrillation (VF) occurring in young adults with no discernible structural or electrocardiographic abnormalities.•A subset of IVF is induced by Purkinj…

Sex differences in ventricular arrhythmia: epidemiology, pathophysiology and catheter ablation Open

Philipp Krisai, Ghassen Cheniti, Takamitsu Takagi, Tsukasa Kamakura, Elodie Surget , et al. · 2022

Evidence on sex differences in the pathophysiology and interventional treatment of ventricular arrhythmia in ischemic (ICM) or non-ischemic cardiomyopathies (NICM) is limited. However, women have different etiologies and types of structura…

L'éveil aux langues pour travailler sur la construction du nombre à l'école Open

Caroline Poisard, Moumin Estelle, Elodie Surget · 2022

International audience

Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: implications for catheter ablation Open

Michel Haı̈ssaguerre, Ghassen Cheniti, Mélèze Hocini, Frédéric Sacher, F. Daniel Ramirez , et al. · 2021

Aims Mapping data of human ventricular fibrillation (VF) are limited. We performed detailed mapping of the activities underlying the onset of VF and targeted ablation in patients with structural cardiac abnormalities. Methods and results W…

Multisite conduction block in the epicardial substrate of Brugada syndrome Open

Michel Haı̈ssaguerre, Koonlawee Nademanee, Frédéric Sacher, Ghassen Cheniti, Mélèze Hocini , et al. · 2021

In BrS, localized functional conduction blocks occur at multiple epicardial sites and with variable patterns, without being reactivated from the surrounding sites.

Sex differences in the origin of Purkinje ectopy-initiated idiopathic ventricular fibrillation Open

Elodie Surget, Ghassen Cheniti, F. Daniel Ramirez, Antoine Leenhardt, Akihiko Nogami , et al. · 2021

Idiopathic Ventricular Fibrillation Open

Michel Haı̈ssaguerre, Josselin Duchâteau, Rémi Dubois, Mélèze Hocini, Ghassen Cheniti , et al. · 2020

Evaluation of the QT Interval in Patients with Drug-induced QT Prolongation and Torsades de Pointes Open

Philipp Krisai, Konstantinos Vlachos, F. Daniel Ramirez, Yosuke Nakatani, Takashi Nakashima , et al. · 2020

Background Data on the optimal location of the ECG leads for the diagnosis of drug-induced long QT syndrome (diLQTS) with Torsades de Pointes (TdP) are lacking. Methods We systematically reviewed the literature for ECGs of patients with di…

Étudier des numérations orales en classe : quels savoirs mathématiques et langagiers ? Open

Caroline Poisard, Martine Kervran, Elodie Surget, Estelle Moumin · 2018

International audience

Contribution of exome sequencing for genetic diagnostic in arrhythmogenic right ventricular cardiomyopathy/dysplasia Open

J. Fedida, Véronique Fressart, Philippe Charron, Elodie Surget, Tiphaine Héry , et al. · 2017

A rather high frequency (5.7%) of large PKP2 deletions, undetectable by Sanger sequencing, was detected as the cause of ARVC/D. Coverage-depth analysis through next-generation sequencing appears accurate to detect large deletions at the sa…

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