Explanipedia

Hepatitis B virus-infected hepatocytes promote the secretion of collagen VI to the extracellular matrix Open

Alessia Virzì, Zakaria Boulahtouf, Julien Moehlin, Lea Girard, Laura Heydmann , et al. · 2025

Chronic hepatitis B virus (HBV) infection is a global health problem as it is the major cause of liver fibrosis and its complications cirrhosis and hepatocellular carcinoma. The role of virus-host interactions in liver fibrosis and progres…

Clinical trials for Hepatitis Delta Virus in the WHO African region: A neglected virus among neglected viruses Open

Marion Delphin, James Campbell, Éloi R. Verrier, Motswedi Anderson, Gloria Sukali , et al. · 2025

Hijacking JAKis: JAK inhibitors as potential antiviral molecules, a mini review Open

Claudie Eber, Éloi R. Verrier · 2025

Janus kinases (JAKs) are key players in the innate immune response and inflammation, catalysing the phosphorylation of STAT proteins, which ultimately leads to the expression of pro-inflammatory and antimicrobial genes. In this context, sp…

A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses Open

Roxanne Fouillé, Éloi R. Verrier, Amse De Meyer, Lieven Verhoye, Maud Michelet , et al. · 2025

Il n’y a pas que l’alphabet viral qui menace le foie Open

Florentin Pastor, Marion Delphin, Julie Lucifora, Éloi R. Verrier · 2025

Le foie est la cible d’infection par de multiples virus susceptibles de causer des dommages importants altérant sa fonction, jusqu’à mettre en péril la vie du patient. Les virus des hépatites « alphabétiques » A, B, C, D et E sont bien car…

Deciphering the links between hepatic viruses and interferons: molecular interactions and therapeutic implications Open

Cassandre Authier, Claudie Eber, Roxanne Fouillé, Julie Lucifora, Éloi R. Verrier · 2025

Interferons (IFNs) are cytokines that play a key role in the innate immune response, possessing antiviral, antiproliferative, and immunomodulatory properties. Currently, IFNs are used clinically as treatments for lymphomas, multiple sclero…

CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1 Open

Valério Taverniti, Laura Heydmann, Cloé Gadenne, Hannah Vanrusselt, Dieudonné Buh Kum , et al. · 2024

Major open questions in the hepatitis B and D field – Proceedings of the inaugural International emerging hepatitis B and hepatitis D researchers workshop Open

Thomas Tu, Jochen M. Wettengel, Yuchen Xia, Barbara Testoni, Margaret Littlejohn , et al. · 2024

Comparative analysis of human, rodent and snake deltavirus replication Open

Pierre Khalfi, Zoé Denis, Joe McKellar, Giovanni Merolla, Carine Chavey , et al. · 2024

The recent discovery of Hepatitis D (HDV) -like viruses across a wide range of taxa led to the establishment of the Kolmioviridae family. Recent studies suggest that kolmiovirids can be satellites of viruses other than Hepatitis B virus (H…

JAK1 promotes HDV replication and is a potential target for antiviral therapy Open

Margaux J. Heuschkel, C Bach, Emanuele Felli, Fabio Giannone, Patrick Pessaux , et al. · 2023

Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles Open

Hannah Vanrusselt, Dieudonné Buh Kum, Valério Taverniti, Cheng Liu, Abel Acosta Sanchez , et al. · 2023

Capsid assembly modulators (CAMs) are a novel class of therapeutic small molecules with the potential to address the continued global challenge posed by chronic hepatitis B (CHB). Class A CAMs (CAM-As) are particularly attractive because t…

Unraveling human, rodent and snakeKolmioviridaereplication to anticipate cross-species transmission Open

Pierre Khalfi, Zoé Denis, Giovanni Merolla, Carine Chavey, José Ursic‐Bedoya , et al. · 2023

The recent discovery of Hepatitis D (HDV)-like viruses across a wide range of taxa led to the establishment of the Kolmioviridae family. Recent studies suggest that kolmiovirids can be satellites of viruses other than Hepatitis B virus (HB…

Unraveling human, rodent and snakeKolmioviridaereplication to anticipate cross-species transmission Open

Pierre Khalfi, Zoé Denis, Giovanni Merolla, Carine Chavey, José Ursic‐Bedoya , et al. · 2023

The recent discovery of Hepatitis D (HDV) -like viruses across a wide range of taxa led to the establishment of the Kolmioviridae family. Recent studies suggest that kolmiovirids can be satellites of viruses other than Hepatitis B virus (H…

Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers Open

Magda Rybicka, Éloi R. Verrier, Thomas F. Baumert, Krzysztof Piotr Bielawski · 2023

Hepatitis D virus interferes with hepatitis B virus RNA production via interferon-dependent and -independent mechanisms Open

Julie Lucifora, Dulce Alfaiate, Caroline Pons, Maud Michelet, Ricardo Ramírez , et al. · 2023

Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target Open

Éloi R. Verrier, Gaëtan Ligat, Laura Heydmann, Katharina Doernbrack, Julija Miller , et al. · 2022

Objectives Chronic hepatitis B virus (HBV) infection is a leading cause of liver disease and hepatocellular carcinoma. A key feature of HBV replication is the synthesis of the covalently close circular (ccc)DNA, not targeted by current tre…

A stable hepatitis D virus-producing cell line for host target and drug discovery Open

C Bach, Julie Lucifora, Marion Delphin, Laura Heydmann, Margaux J. Heuschkel , et al. · 2022

Chronic hepatitis D is the most aggressive form of chronic viral hepatitis. It is caused by super-infection of hepatitis B virus (HBV)-infected hepatocytes with hepatitis D virus (HDV). While the recent conditional approval of bulevirtide …

Récepteur du virus de l’hépatite B Open

Éloi R. Verrier · 2022

No abstract available

Inhibiting cell-to-cell transmission to reach HDV cure: The importance of IFN-α Open

Julie Lucifora, Éloi R. Verrier, Thomas F. Baumert · 2022

Plaidoyer pour faire de la recherche un enjeu électoral Open

Éloi R. Verrier · 2022

No abstract available

Signaling Induced by Chronic Viral Hepatitis: Dependence and Consequences Open

Zakaria Boulahtouf, Alessia Virzì, Thomas F. Baumert, Éloi R. Verrier, Joachim Lupberger · 2022

Chronic viral hepatitis is a main cause of liver disease and hepatocellular carcinoma. There are striking similarities in the pathological impact of hepatitis B, C, and D, although these diseases are caused by very different viruses. Paire…

Capsid Assembly Modulators as Antiviral Agents against HBV: Molecular Mechanisms and Clinical Perspectives Open

Valério Taverniti, Gaëtan Ligat, Yannick Debing, Dieudonné Buh Kum, Thomas F. Baumert , et al. · 2022

Despite a preventive vaccine being available, more than 250 million people suffer from chronic hepatitis B virus (HBV) infection, a major cause of liver disease and HCC. HBV infects human hepatocytes where it establishes its genome, the cc…

Loss of hepatitis D virus infectivity upon farnesyl transferase inhibitor treatment associates with increasing RNA editing rates revealed by a new RT-ddPCR method Open

Éloi R. Verrier, Anna Salvetti, Caroline Pons, Maud Michelet, Michel Rivoire , et al. · 2022

Chronic hepatitis D is the most severe form of chronic viral hepatitis and to date, efficient therapeutic approaches against hepatitis D virus (HDV) are limited. Among the antiviral molecules currently tested in clinical trials, the farnes…

Editorial: Nucleic Acid-Associated Inflammation Open

Nadine Laguette, Christelle Langevin, David Olagnier, Vincenzo Torraca, Claire Vanpouille‐Box , et al. · 2021

PMC8579011

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery Open

Émilie Crouchet, Simonetta Bandiera, Naoto Fujiwara, Shen Li, Hussein El Saghire , et al. · 2021

Cell Culture Models for the Study of Hepatitis D Virus Entry and Infection Open

Margaux J. Heuschkel, Thomas F. Baumert, Éloi R. Verrier · 2021

Chronic hepatitis D is one of the most severe and aggressive forms of chronic viral hepatitis with a high risk of developing hepatocellular carcinoma (HCC). It results from the co-infection of the liver with the hepatitis B virus (HBV) and…

Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma Open

Frank Juehling, Antonio Saviano, Clara Ponsolles, Laura Heydmann, Émilie Crouchet , et al. · 2021

Chronic hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma (HCC) world-wide. The molecular mechanisms of viral hepatocarcinogenesis are still partially understood. Here, we applied two complementary single-cell …

Jet virology: analysis of scientific publications during pandemics Open

Éloi R. Verrier · 2021

International audience

Hepatitis B virus–host interactions and novel targets for viral cure Open

Gaëtan Ligat, Éloi R. Verrier, Michael Nassal, Thomas F. Baumert · 2021

Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing Open

Éloi R. Verrier, Christelle Langevin · 2021

Innate immune pathways are the first line of cellular defense against pathogen infections ranging from bacteria to Metazoa. These pathways are activated following the recognition of pathogen associated molecular patterns (PAMPs) by membran…

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