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View article: An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice Open
Impaired mitochondrial bioenergetics in macrophages promotes hyperinflammatory cytokine responses, but whether inherited mtDNA mutations drive similar phenotypes is unknown. Here, we profiled macrophages harbouring a heteroplasmic mitochon…
View article: An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and <i>in vivo</i>
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and <i>in vivo</i> Open
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses 1–6 , but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this question using a multi-omic approac…
View article: Multifaceted mitochondria in innate immunity
Multifaceted mitochondria in innate immunity Open
The ability of mitochondria to transform the energy we obtain from food into cell phosphorylation potential has long been appreciated. However, recent decades have seen an evolution in our understanding of mitochondria, highlighting their …
View article: Lcn2 protects from cisplatin induced AKI by regulating DNA damage response via EGFR activation
Lcn2 protects from cisplatin induced AKI by regulating DNA damage response via EGFR activation Open
SUMMARY Background Lipocalin 2 (Lcn2), a small-secreted protein, is an established sensitive biomarker of kidney injury. In Cisplatin (CDDP) induced acute kidney injury (AKI), Lcn2 expression is swiftly and strongly increased in suffering …