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View article: Which pre‐analytical confounder matters the most in the comparison of two cohorts? Tubes and storage fill volume put to the test
Which pre‐analytical confounder matters the most in the comparison of two cohorts? Tubes and storage fill volume put to the test Open
Background The tubes used for collection and storage and their fill volumes have been identified as critical elements for standardized CSF collection as they have proven to significantly influence recovery of CSF biomarker levels and β‐amy…
View article: Concordance of Lumipulse cerebrospinal fluid t‐tau/Aβ42 ratio with amyloid PET status
Concordance of Lumipulse cerebrospinal fluid t‐tau/Aβ42 ratio with amyloid PET status Open
Introduction Cerebrospinal fluid (CSF) biomarkers can identify individuals with Alzheimer's disease (AD) pathology (eg, amyloid plaques, neurofibrillary tangles), but defined analyte cut‐points using high‐throughput automated assays are ne…
View article: Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse
Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse Open
Objective To determine the cutoffs that optimized the agreement between 18 F‐Florbetapir positron emission tomography (PET) and A β 1‐42, A β 1‐40, tTau, pTau and their ratios measured in cerebrospinal fluid (CSF) on the LUMIPULSE G600II i…
View article: P1‐266: COMPARISON OF A FULLY AUTOMATED BEAD‐BASED SYSTEM WITH AN ENZYME‐LINKED IMMUNOSORBENT ASSAY AND AN ELECTROCHEMILUMINESCENT ASSAY FOR MEASUREMENT OF CORE AD BIOMARKERS
P1‐266: COMPARISON OF A FULLY AUTOMATED BEAD‐BASED SYSTEM WITH AN ENZYME‐LINKED IMMUNOSORBENT ASSAY AND AN ELECTROCHEMILUMINESCENT ASSAY FOR MEASUREMENT OF CORE AD BIOMARKERS Open
The CSF biomarkers beta-amyloid (Aβ) 1–40 and 1-42, p-tau, and t-tau are used in research to categorize Alzheimer's disease (AD) and in the clinical setting where they offer support for the diagnosis of AD. Compared to Ab42 the Ab42/Aβ40 r…
View article: Agreement between <sup>18</sup>F-Florbetapir PET imaging and cerebrospinal fluid Aβ1-42, Aβ1-40, tTau and pTau measured on the LUMIPULSE G fully automated platform
Agreement between <sup>18</sup>F-Florbetapir PET imaging and cerebrospinal fluid Aβ1-42, Aβ1-40, tTau and pTau measured on the LUMIPULSE G fully automated platform Open
INTRODUCTION The development of fully automated immunoassay platforms has improved the technical reliability of cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease. METHODS We quantified Aβ1-42, Aβ1-40, tTau and pTau levels using …