Elsa C. Chan
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View article: Inhibitory Effects of 3′,4′‐Dihydroxyflavonol in a Rabbit Model of Minimally Invasive Bleb Surgery With <scp>PreserFlo MicroShunt</scp>
Inhibitory Effects of 3′,4′‐Dihydroxyflavonol in a Rabbit Model of Minimally Invasive Bleb Surgery With <span>PreserFlo MicroShunt</span> Open
Background The success of minimally invasive bleb surgery (MIBS) such as the PreserFlo MicroShunt (PFMS) is limited by post‐operative bleb fibrosis. Current clinical practice prescribes the use of off‐label cytotoxic antimetabolites such a…
View article: Corneal Neovascularisation and Anti-VEGF Therapy
Corneal Neovascularisation and Anti-VEGF Therapy Open
Cornea vascularisation is a significant cause of ocular morbidity. Disease or injury often triggers the development of new blood vessels in the cornea, compromising its clarity and impairing vision. Common causes of corneal neovascularisat…
View article: 3′,4′-Dihydroxyflavonol Inhibits Fibrotic Response in a Rabbit Model of Glaucoma Filtration Surgery
3′,4′-Dihydroxyflavonol Inhibits Fibrotic Response in a Rabbit Model of Glaucoma Filtration Surgery Open
Post-operative fibrosis of the filtering bleb limits the success of glaucoma filtration surgery (GFS). To minimise subconjunctival scarring following GFS, treatment with antimetabolites such as Mitomycin C (MMC) has become standard practic…
View article: Transcriptomic analysis of TGFβ-mediated fibrosis in primary human Tenon’s fibroblasts
Transcriptomic analysis of TGFβ-mediated fibrosis in primary human Tenon’s fibroblasts Open
Glaucoma filtration surgery (GFS) is performed to slow down disease progression in glaucoma, a leading cause of irreversible blindness worldwide. Following surgery, pathological wound healing may lead to conjunctival fibrosis and filtering…
View article: Transcriptomic analysis of TGFβ-mediated fibrosis in primary human Tenon’s fibroblasts
Transcriptomic analysis of TGFβ-mediated fibrosis in primary human Tenon’s fibroblasts Open
Glaucoma filtration surgery (GFS) is performed to slow down disease progression in glaucoma, a leading cause of irreversible blindness worldwide. Following surgery, pathological wound healing may lead to conjunctival fibrosis and filtering…
View article: Inhibitory Effects of 3′,4′-Dihydroxyflavonol in a Mouse Model of Glaucoma Filtration Surgery and TGFβ1-Induced Responses in Human Tenon's Fibroblasts
Inhibitory Effects of 3′,4′-Dihydroxyflavonol in a Mouse Model of Glaucoma Filtration Surgery and TGFβ1-Induced Responses in Human Tenon's Fibroblasts Open
DiOHF may be a safer and superior wound modulating agent than conventional antifibrotic therapy in GFS.
View article: Oxidative Stress and the Role of NADPH Oxidase in Glaucoma
Oxidative Stress and the Role of NADPH Oxidase in Glaucoma Open
Glaucoma is characterised by loss of retinal ganglion cells, and their axons and many pathophysiological processes are postulated to be involved. It is increasingly understood that not one pathway underlies glaucoma aetiology, but rather t…
View article: Nox4 Facilitates TGFβ1-Induced Fibrotic Response in Human Tenon’s Fibroblasts and Promotes Wound Collagen Accumulation in Murine Model of Glaucoma Filtration Surgery
Nox4 Facilitates TGFβ1-Induced Fibrotic Response in Human Tenon’s Fibroblasts and Promotes Wound Collagen Accumulation in Murine Model of Glaucoma Filtration Surgery Open
Collagen accumulation in sub-conjunctival tissue at the surgical wound is one of the major complications associated with glaucoma filtration surgery (GFS). This process often leads to unwanted fibrotic scar formation at the lesion site and…
View article: Wound Healing After Alkali Burn Injury of the Cornea Involves Nox4-Type NADPH Oxidase
Wound Healing After Alkali Burn Injury of the Cornea Involves Nox4-Type NADPH Oxidase Open
Nox4 could be a new target to treat pathologic corneal wound-healing responses and such targeting might prevent blindness caused by burn injuries.
View article: OCX063, a novel small molecule drug, is protective against inflammatory, fibrotic and angiogenic phenotypes in retinal cultures
OCX063, a novel small molecule drug, is protective against inflammatory, fibrotic and angiogenic phenotypes in retinal cultures Open
View article: Oral administration of the novel small molecule drug OCX063 protects against inflammation and vascular pathology in a rat diabetic retinopathy (DR) model
Oral administration of the novel small molecule drug OCX063 protects against inflammation and vascular pathology in a rat diabetic retinopathy (DR) model Open
View article: A biocompatible reverse thermoresponsive polymer for ocular drug delivery
A biocompatible reverse thermoresponsive polymer for ocular drug delivery Open
Age-related macular degeneration (AMD) is a leading cause of vision loss, the treatment of which may require monthly intravitreal injections. This is a burden on patients and health services, and new delivery modalities that reduce injecti…
View article: Interrogating new targets for glaucoma gene therapy
Interrogating new targets for glaucoma gene therapy Open
View article: Table of Contents
Table of Contents Open
View article: Adventitial Activation in the Pathogenesis of Injury-Induced Arterial Remodeling
Adventitial Activation in the Pathogenesis of Injury-Induced Arterial Remodeling Open
View article: Transforming Growth Factor β1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts
Transforming Growth Factor β1–Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts Open
The present study suggests that TGFβ1-mediated production of collagen by conjunctival fibroblasts involves Nox4-derived H2O2 pathway and this effect of Nox4 is abrogated by curcumin. This mechanism might be exploited to prevent fibrotic sc…
View article: Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation for Tissue Engineering Applications
Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation for Tissue Engineering Applications Open
Here, we describe a porous 3-dimensional collagen scaffold material that supports capillary formation in vitro, and promotes vascularization when implanted in vivo. Collagen scaffolds were synthesized from type I bovine collagen and have a…
View article: Nanocarriers for Treatment of Ocular Neovascularization in the Back of the Eye: New Vehicles for Ophthalmic Drug Delivery
Nanocarriers for Treatment of Ocular Neovascularization in the Back of the Eye: New Vehicles for Ophthalmic Drug Delivery Open
Pathologic neovascularization of the retina is a major cause of substantial and irreversible loss of vision. Drugs are difficult to deliver to the lesions in the back of the eye and this is a major obstacle for the therapeutics. Current ph…
View article: Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy
Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy Open
Age-related macular degeneration (AMD) is the leading cause of substantial and irreversible vision loss amongst elderly populations in industrialized countries. The advanced neovascular (or “wet”) form of the disease is responsible for sev…