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View article: A multi-strain human skin microbiome model provides a testbed for disease modeling
A multi-strain human skin microbiome model provides a testbed for disease modeling Open
The skin microbiome plays a critical role at the interface between the human epidermis and the environment, providing colonization resistance against pathogenic strains, training host immunity, and supporting epithelial turnover. Inversely…
View article: A Clinical‐Scale Microfluidic Respiratory Assist Device with 3D Branching Vascular Networks
A Clinical‐Scale Microfluidic Respiratory Assist Device with 3D Branching Vascular Networks Open
Recent global events such as COVID‐19 pandemic amid rising rates of chronic lung diseases highlight the need for safer, simpler, and more available treatments for respiratory failure, with increasing interest in extracorporeal membrane oxy…
View article: A high-throughput, 28-day, microfluidic model of gingival tissue inflammation and recovery
A high-throughput, 28-day, microfluidic model of gingival tissue inflammation and recovery Open
Nearly half of American adults suffer from gum disease, including mild inflammation of gingival tissue, known as gingivitis. Currently, advances in therapeutic treatments are hampered by a lack of mechanistic understanding of disease progr…
View article: Steady-state monitoring of oxygen in a high-throughput organ-on-chip platform enables rapid and non-invasive assessment of drug-induced nephrotoxicity
Steady-state monitoring of oxygen in a high-throughput organ-on-chip platform enables rapid and non-invasive assessment of drug-induced nephrotoxicity Open
Measurement of steady-state oxygen levels in a high-throughput organ-on-chip platform enabled rapid and non-invasive monitoring of dose and time-dependent injury responses of human kidney cells to cisplatin, a drug with toxic effects in th…
View article: Evaluation of rapid transepithelial electrical resistance (TEER) measurement as a metric of kidney toxicity in a high-throughput microfluidic culture system
Evaluation of rapid transepithelial electrical resistance (TEER) measurement as a metric of kidney toxicity in a high-throughput microfluidic culture system Open
Rapid non-invasive kidney-specific readouts are essential to maximizing the potential of microfluidic tissue culture platforms for drug-induced nephrotoxicity screening. Transepithelial electrical resistance (TEER) is a well-established te…
View article: Multilayer Scaling of a Biomimetic Microfluidic Oxygenator
Multilayer Scaling of a Biomimetic Microfluidic Oxygenator Open
Extracorporeal membrane oxygenation (ECMO) has been advancing rapidly due to a combination of rising rates of acute and chronic lung diseases as well as significant improvements in the safety and efficacy of this therapeutic modality. Howe…
View article: Toward Development of a Higher Flow Rate Hemocompatible Biomimetic Microfluidic Blood Oxygenator
Toward Development of a Higher Flow Rate Hemocompatible Biomimetic Microfluidic Blood Oxygenator Open
The recent emergence of microfluidic extracorporeal lung support technologies presents an opportunity to achieve high gas transfer efficiency and improved hemocompatibility relative to the current standard of care in extracorporeal membran…
View article: High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows
High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows Open
96 microfluidic devices with independent electrical readouts are coupled with 192 micropumps to make a high-throughput organ-on-chip platform.
View article: Correction: A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions
Correction: A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions Open
Correction for ‘A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions’ by Kelly Tan et al., Lab Chip, 2019, 19, 1556–1566, DOI: 10.1039/C8LC0126…
View article: Effect of flow on targeting and penetration of angiopep-decorated nanoparticles in a microfluidic model blood-brain barrier
Effect of flow on targeting and penetration of angiopep-decorated nanoparticles in a microfluidic model blood-brain barrier Open
The blood-brain barrier (BBB) limits transport of nanoparticles from the circulation to the brain parenchyma. Angiopep-2, a peptide which functions as a brain transport vector, can be coupled to nanoparticles in order to facilitate binding…
View article: A microfluidic renal proximal tubule with active reabsorptive function
A microfluidic renal proximal tubule with active reabsorptive function Open
In the kidney, the renal proximal tubule (PT) reabsorbs solutes into the peritubular capillaries through active transport. Here, we replicate this reabsorptive function in vitro by engineering a microfluidic PT. The microfluidic PT archite…
View article: A Microfluidic Renal Proximal Tubule with Active Reabsorptive Function data set
A Microfluidic Renal Proximal Tubule with Active Reabsorptive Function data set Open
Raw data for figures 2, 3, 4 from PLoS ONE publication