Elsie Cheruba
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View article: DARESOME enables concurrent profiling of multiple DNA modifications with restriction enzymes in single cells and cell-free DNA
DARESOME enables concurrent profiling of multiple DNA modifications with restriction enzymes in single cells and cell-free DNA Open
5-Methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the most abundant DNA modifications that have important roles in gene regulation. Detailed studies of these different epigenetic marks aimed at understanding their combined effe…
View article: Heat selection enables highly scalable methylome profiling in cell-free DNA for noninvasive monitoring of cancer patients
Heat selection enables highly scalable methylome profiling in cell-free DNA for noninvasive monitoring of cancer patients Open
Genome-wide analysis of cell-free DNA methylation profile is a promising approach for sensitive and specific detection of many cancers. However, scaling such assays for clinical translation is impractical because of the high cost of whole-…
View article: Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis
Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis Open
Focal adhesions (FAs) are specialized structures that enable cells to sense their extracellular matrix rigidity and transmit these signals to the interior of the cells, bringing about actin cytoskeleton reorganization, FA maturation, and c…
View article: Heatrich-BS enables efficient CpG enrichment and highly scalable cell-free DNA methylation profiling
Heatrich-BS enables efficient CpG enrichment and highly scalable cell-free DNA methylation profiling Open
Genome wide analysis of cell-free DNA (cfDNA) methylation profile has been shown to be a promising approach for sensitive and specific multi-cancer detection. However, scaling these assays for clinical translation is impractical due to the…
View article: DNA Analysis by Restriction Enzyme (DARE) enables concurrent genomic and epigenomic characterization of single cells
DNA Analysis by Restriction Enzyme (DARE) enables concurrent genomic and epigenomic characterization of single cells Open
Genome-wide profiling of copy number alterations and DNA methylation in single cells could enable detailed investigation into the genomic and epigenomic heterogeneity of complex cell populations. However, current methods to do this require…
View article: Phosphatase POPX2 Exhibits Dual Regulatory Functions in Cancer Metastasis
Phosphatase POPX2 Exhibits Dual Regulatory Functions in Cancer Metastasis Open
Cancer metastasis is a complex mechanism involving multiple processes. Previously, our integrative proteome, transcriptome, and phosphoproteome study reported that the levels of serine/threonine phosphatase POPX2 were positively correlated…