Explanipedia

Carbon monoxide exposure in pregnant women in the UK Open

Elsie Place, Hilary Wareing, Mari Herigstad · 2025

Balancing SHH and BMP/FGF10 to specify tuberal hypothalamic neurons and glia Open

Kavitha Chinnaiya, Ian Groves, Elizabeth Manning, Elsie Place, Caitlyn Furley , et al. · 2025

The tuberal hypothalamus harbours clinically important neuronal and glial populations with central roles in energy homeostasis. Previous work has revealed key roles for SHH and BMP signalling in tuberal progenitor specification, and sugges…

Decoding gene networks controlling hypothalamic and prethalamic neuron development Open

Dong Won Kim, Leighton H. Duncan, Zheng Xu, Minzi Chang, Sara Sejer , et al. · 2025

The hypothalamus and prethalamus regulate diverse physiological and behavioral processes, yet the gene regulatory networks guiding their development remain poorly defined. Using single-cell RNA and ATAC sequencing, we profile over 660,000 …

Decoding Gene Networks Controlling Hypothalamic and Prethalamic Neuron Development Open

Dong Won Kim, Leighton H. Duncan, Jinchao Xu, Minzi Chang, Søren Schwartz Sørensen , et al. · 2025

Summary Neuronal subtypes derived from the embryonic hypothalamus and prethalamus regulate many essential physiological processes, yet the gene regulatory networks controlling their development remain poorly understood. Using single-cell R…

Resolving forebrain developmental organisation by analysis of differential growth patterns Open

Elizabeth Manning, Kavitha Chinnaiya, Caitlyn Furley, Dong Won Kim, Seth Blackshaw , et al. · 2025

The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombination lineage tracing, and built a 4D m…

Balancing Shh and Bmp/Fg10 Signals to Specify Hypothalamic Neurons and Glia Open

Marysia Placzek, Kavitha Chinnaiya, Ian Groves, Elizabeth Manning, Caitlyn Furley , et al. · 2024

A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus Open

Kavitha Chinnaiya, Sarah Burbridge, Aragorn Jones, Dong Won Kim, Elsie Place , et al. · 2023

The tuberal hypothalamus controls life-supporting homeostatic processes, but despite its fundamental role, the cells and signalling pathways that specify this unique region of the central nervous system in embryogenesis are poorly characte…

Author response: A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus Open

Kavitha Chinnaiya, Sarah Burbridge, Aragorn Jones, Dong Won Kim, Elsie Place , et al. · 2022

Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The tuberal hypothalam…

A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus Open

Kavitha Chinnaiya, Sarah Burbridge, Aragorn Jones, Dong Won Kim, Elsie Place , et al. · 2022

The tuberal hypothalamus houses several major hypothalamic nuclei, dozens of transcriptionally distinct cell types, and clinically relevant cell populations implicated in obesity and related metabolic disorders. Building on recent advances…

SHH and Notch regulate SOX9+ progenitors to govern arcuate POMC neurogenesis Open

Elsie Place, Elizabeth Manning, Dong Won Kim, Arisa Kinjo, Go Nakamura , et al. · 2022

Pro-opiomelanocortin (POMC)-expressing neurons in the hypothalamic arcuate nucleus (ARC) play key roles in feeding and energy homoeostasis, hence their development is of great research interest. As the process of neurogenesis is accompanie…

Single-cell analysis of early chick hypothalamic development reveals that hypothalamic cells are induced from prethalamic-like progenitors Open

Dong Won Kim, Elsie Place, Kavitha Chinnaiya, Elizabeth Manning, Changyu Sun , et al. · 2022

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva Open

Eleanor Williams, Jana Bagarova, Georgina Kerr, Dong-Dong Xia, Elsie Place , et al. · 2021

Currently, no effective therapies exist for fibrodysplasia ossificans progressiva (FOP), a rare congenital syndrome in which heterotopic bone is formed in soft tissues owing to dysregulated activity of the bone morphogenetic protein (BMP) …

Value of systematic genetic screening of patients with amyotrophic lateral sclerosis Open

Stephanie Shepheard, Matthew Parker, Johnathan Cooper‐Knock, Nick Verber, Lee Tuddenham , et al. · 2021

Objective The clinical utility of routine genetic sequencing in amyotrophic lateral sclerosis (ALS) is uncertain. Our aim was to determine whether routine targeted sequencing of 44 ALS-relevant genes would have a significant impact on dise…

Single-Cell Analysis of Early Hypothalamic Development Reveals that Hypothalamic Cells are Induced from Prethalamic-Like Progenitors Open

Dong Won Kim, Elsie Place, Kavitha Chinnaiya, Elizabeth Manning, Changyu Sun , et al. · 2021

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva Open

Eleanor Williams, Jana Bagarova, Georgina Kerr, Dong-Dong Xia, Elsie Place , et al. · 2020

Currently, no effective therapies exist for fibrodysplasia ossificans progressiva (FOP), a rare congenital syndrome in which heterotopic bone is formed in soft tissues due to dysregulated activity of the bone morphogenetic protein (BMP) re…

Correction: Zebrafish atoh8 mutants do not recapitulate morpholino phenotypes Open

Elsie Place, James C. Smith · 2017

[This corrects the article DOI: 10.1371/journal.pone.0171143.].

Comparison of Zebrafish tmem88a mutant and morpholino knockdown phenotypes Open

Alex Eve, Elsie Place, James C. Smith · 2017

Tmem88a is a transmembrane protein that is thought to be a negative regulator of the Wnt signalling pathway. Several groups have used antisense morpholino oligonucleotides in an effort to characterise the role of tmem88a in zebrafish cardi…

Zebrafish atoh8 mutants do not recapitulate morpholino phenotypes Open

Elsie Place, James C. Smith · 2017

Atoh8 is a bHLH transcription factor expressed in pancreas, skeletal muscle, the nervous system, and cardiovascular tissues during embryological development. Although it has been implicated in the regulation of pancreatic and endothelial c…

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