Elsio A. Wunder
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View article: DMEM and EMEM are suitable surrogate media to mimic host environment and expand leptospiral pathogenesis studies using <i>in vitro</i> tools
DMEM and EMEM are suitable surrogate media to mimic host environment and expand leptospiral pathogenesis studies using <i>in vitro</i> tools Open
Pathogenic Leptospira species can survive and thrive in a wide range of environments. Distinct environments expose the bacteria to different temperatures, osmolarities, and amounts and sources of nutrition. However, leptospires are mostly …
View article: <i>Leptospira</i> Leptolysin Contributes to Serum Resistance but Is Not Essential for Acute Infection
<i>Leptospira</i> Leptolysin Contributes to Serum Resistance but Is Not Essential for Acute Infection Open
Previous in vitro works focusing on virulence determinants of the spirochete Leptospira implicated metalloproteinases as putative contributing factors to the pathogenicity of these bacteria. Those proteins have the capacity to degrade extr…
View article: Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil
Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil Open
Background Leptospirosis is a zoonosis caused by pathogenic species of bacteria belonging to the genus Leptospira . Most studies infer the epidemiological patterns of a single serogroup or aggregate all serogroups to estimate overall serop…
View article: Eco-epidemiological study of seropositivity against Rickettsia and Leptospira agents in rural areas of Urabá, Colombia.
Eco-epidemiological study of seropositivity against Rickettsia and Leptospira agents in rural areas of Urabá, Colombia. Open
Rickettsioses and leptospirosis are infectious diseases that are often underdiagnosed due to a lack of knowledge about their epidemiology, pathophysiology, diagnosis, management, among others. Objetive: to characterize the seroprevalence a…
View article: Lysinoalanine cross-linking is a conserved post-translational modification in the spirochete flagellar hook
Lysinoalanine cross-linking is a conserved post-translational modification in the spirochete flagellar hook Open
Spirochetes cause Lyme disease, leptospirosis, syphilis, and several other human illnesses. Unlike other bacteria, spirochete flagella are enclosed within the periplasmic space where the filaments distort and push the cell body by the acti…
View article: MPL36, a major plasminogen (PLG) receptor in pathogenic Leptospira, has an essential role during infection
MPL36, a major plasminogen (PLG) receptor in pathogenic Leptospira, has an essential role during infection Open
Leptospirosis, a zoonosis with worldwide distribution, is caused by pathogenic spirochetes belonging to the genus Leptospira . Bacterial outer membrane proteins (OMPs), particularly those with surface-exposed regions, play crucial roles in…
View article: Lysinoalanine crosslinking is a conserved post-translational modification in the spirochete flagellar hook
Lysinoalanine crosslinking is a conserved post-translational modification in the spirochete flagellar hook Open
Spirochete bacteria cause Lyme disease, leptospirosis, syphilis and several other human illnesses. Unlike other bacteria, spirochete flagella are enclosed within the periplasmic space where the filaments distort and push the cell body by a…
View article: Molecular Characterization of Leptospira Species Detected in the Kidneys of Slaughtered Livestock in Abattoirs in Gauteng Province, South Africa
Molecular Characterization of Leptospira Species Detected in the Kidneys of Slaughtered Livestock in Abattoirs in Gauteng Province, South Africa Open
Leptospira was investigated in kidneys (n = 305) from slaughtered livestock in the Gauteng Province abattoirs, South Africa, using a culture medium to isolate Leptospira, followed by the LipL32 qPCR to detect Leptospira DNA. The SecY gene …
View article: Factors associated with differential seropositivity to<i>Leptospira interrogans</i>and<i>Leptospira kirschneri</i>in a high transmission urban setting for leptospirosis in Brazil
Factors associated with differential seropositivity to<i>Leptospira interrogans</i>and<i>Leptospira kirschneri</i>in a high transmission urban setting for leptospirosis in Brazil Open
Background Leptospirosis is a zoonosis caused by pathogenic species of bacteria belonging to the genus Leptospira . Most studies infer the epidemiological patterns of a single serogroup or aggregate all serogroups to estimate overall serop…
View article: MPL36, a major plasminogen (PLG) receptor in pathogenic<i>Leptospira,</i>has an essential role during infection
MPL36, a major plasminogen (PLG) receptor in pathogenic<i>Leptospira,</i>has an essential role during infection Open
Leptospirosis, a zoonosis with worldwide distribution, is caused by pathogenic spirochetes belonging to the genus Leptospira . Bacterial outer membrane proteins (OMPs), particularly those with surface-exposed regions, play crucial roles in…
View article: Leptospira Infection in Rural Areas of Urabá Region, Colombia: A Prospective Study
Leptospira Infection in Rural Areas of Urabá Region, Colombia: A Prospective Study Open
The objective of this study was to analyze the eco-epidemiological aspects of Leptospira seroprevalence and seroincidence and its associated factors in two municipalities of northwest Colombia. A prospective study was performed in rural ar…
View article: Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella
Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella Open
[This corrects the article DOI: 10.3389/fimmu.2020.02007.].
View article: Rickettsial Infections Causing Acute Febrile Illness in Urban Slums, Brazil
Rickettsial Infections Causing Acute Febrile Illness in Urban Slums, Brazil Open
We conducted enhanced acute febrile illness surveillance in an urban slum community in Salvador, Brazil. We found that rickettsial infection accounted for 3.5% of urgent care visits for acute fever. Our results suggest that rickettsiae mig…
View article: Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil Open
Background: Zoonotic spillover from animal reservoirs is responsible for a significant global public health burden, but the processes that promote spillover events are poorly understood in complex urban settings. Endemic transmission of Le…
View article: Structural factors associated with SARS-CoV-2 infection risk in an urban slum setting in Salvador, Brazil: A cross-sectional survey
Structural factors associated with SARS-CoV-2 infection risk in an urban slum setting in Salvador, Brazil: A cross-sectional survey Open
Background The structural environment of urban slums, including physical, demographic, and socioeconomic attributes, renders inhabitants more vulnerable to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Yet, little…
View article: Author response: Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil
Author response: Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil Open
Article Figures and data Abstract Editor's evaluation Introduction Materials and methods Results Discussion Appendix 1 Appendix 2 Appendix 3 Appendix 4 Appendix 5 Appendix 6 Appendix 7 Appendix 8 Data availability References Decision lette…
View article: Biannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, Brazil
Biannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, Brazil Open
Introduction Leptospirosis is a zoonosis with a worldwide spread that leads to clinical manifestations ranging from asymptomatic infection to a life-threatening disease. The immune response is predominantly humoral mediated limited to the …
View article: Rainfall and other meteorological factors as drivers of urban transmission of leptospirosis
Rainfall and other meteorological factors as drivers of urban transmission of leptospirosis Open
Background Leptospirosis is an important public health problem affecting vulnerable urban slum populations in developing country settings. However, the complex interaction of meteorological factors driving the temporal trends of leptospiro…
View article: De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report Open
SARS-CoV-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. We present a case of an immunocompromised patient with acquired B-cell deficiency …
View article: Structural basis of flagellar filament asymmetry and supercoil templating by <i>Leptospira</i> spirochete sheath proteins
Structural basis of flagellar filament asymmetry and supercoil templating by <i>Leptospira</i> spirochete sheath proteins Open
Several Leptospira species are bacterial agents of leptospirosis, a neglected tropical disease responsible for ~ 1 million cases and 50,000 deaths each year worldwide. Leptospira , like other members of the Spirochaeta phylum, possess spec…
View article: Structural factors contributing to SARS-CoV-2 infection risk in the urban slum setting
Structural factors contributing to SARS-CoV-2 infection risk in the urban slum setting Open
Background The structural environment of urban slums, including physical, demographic and socioeconomic attributes, renders inhabitants more vulnerable to SARS-CoV-2 infection. Yet, little is known about the specific determinants that cont…
View article: Sero-prevalence of anti-Leptospira antibodies and associated risk factors in rural Rwanda: A cross-sectional study
Sero-prevalence of anti-Leptospira antibodies and associated risk factors in rural Rwanda: A cross-sectional study Open
Background Leptospirosis is a zoonotic disease transmitted through the urine of wild and domestic animals, and is responsible for over 50,000 deaths each year. In East Africa, prevalence varies greatly, from as low as 7% in Kenya to 37% in…
View article: Effect of Sewerage on the Contamination of Soil with Pathogenic <i>Leptospira</i> in Urban Slums
Effect of Sewerage on the Contamination of Soil with Pathogenic <i>Leptospira</i> in Urban Slums Open
Leptospirosis is an environmentally transmitted zoonotic disease caused by pathogenic Leptospira spp. that affects poor communities worldwide. In urban slums, leptospirosis is associated with deficient sanitary infrastructure. Yet, the rol…
View article: <i>De novo</i> emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: A case report
<i>De novo</i> emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: A case report Open
SARS-CoV-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. We present a case of an immunocompromised patient with acquired B-cell deficiency …
View article: <i>Leptospira</i> infection in rural areas of Urabá region, Colombia: a prospective study
<i>Leptospira</i> infection in rural areas of Urabá region, Colombia: a prospective study Open
The objective of this study was to analyze the eco-epidemiological aspects of Leptospira seroprevalence and seroincidence, and its associated factors in two municipalities of northwest Colombia. A prospective study was performed in rural a…
View article: Linking rattiness, geography and environmental degradation to spillover <i>Leptospira</i> infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil
Linking rattiness, geography and environmental degradation to spillover <i>Leptospira</i> infections in marginalised urban settings: an eco-epidemiological community-based cohort study in Brazil Open
Background Zoonotic spillover from animal reservoirs is responsible for a significant global public health burden, but the processes that promote spillover events are poorly understood in complex urban settings. Endemic transmission of Lep…