Elton Ho
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View article: Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation
Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation Open
High-bandwidth brain-computer interfaces rely on invasive surgical procedures or brain-penetrating electrodes. Here we describe a cortical 1,024-channel thin-film microelectrode array and we demonstrate its minimally invasive surgical deli…
View article: First-in-human experience performing high-resolution cortical mapping using a novel microelectrode array containing 1024 electrodes
First-in-human experience performing high-resolution cortical mapping using a novel microelectrode array containing 1024 electrodes Open
Objective. Localization of function within the brain and central nervous system is an essential aspect of clinical neuroscience. Classical descriptions of functional neuroanatomy provide a foundation for understanding the functional signif…
View article: Electronic photoreceptors enable prosthetic visual acuity matching the natural resolution in rats
Electronic photoreceptors enable prosthetic visual acuity matching the natural resolution in rats Open
View article: The Layer 7 Cortical Interface: A Scalable and Minimally Invasive Brain–Computer Interface Platform
The Layer 7 Cortical Interface: A Scalable and Minimally Invasive Brain–Computer Interface Platform Open
Progress toward the development of brain–computer interfaces has signaled the potential to restore, replace, and augment lost or impaired neurological function in a variety of disease states. Existing approaches to developing high-bandwidt…
View article: Electronic “photoreceptors” enable prosthetic vision with acuity matching the natural resolution in rats
Electronic “photoreceptors” enable prosthetic vision with acuity matching the natural resolution in rats Open
Localized stimulation of the inner retinal neurons for high-acuity prosthetic vision requires small pixels and minimal cross-talk from neighboring electrodes. Local return electrodes within each pixel limit crosstalk, but can over-constrai…
View article: Vertical-junction photodiodes for smaller pixels in retinal prostheses
Vertical-junction photodiodes for smaller pixels in retinal prostheses Open
Objective. To restore central vision in patients with atrophic age-related macular degeneration, we replace the lost photoreceptors with photovoltaic pixels, which convert light into current and stimulate the secondary retinal neurons. Cli…
View article: Decoding network-mediated retinal response to electrical stimulation: implications for fidelity of prosthetic vision
Decoding network-mediated retinal response to electrical stimulation: implications for fidelity of prosthetic vision Open
Objective . Patients with photovoltaic subretinal implant PRIMA demonstrated letter acuity ∼0.1 logMAR worse than sampling limit for 100 μ m pixels (1.3 logMAR) and performed slower than healthy subjects tested with equivalently pixelated …
View article: Decoding network-mediated retinal response to electrical stimulation: implications for fidelity of prosthetic vision
Decoding network-mediated retinal response to electrical stimulation: implications for fidelity of prosthetic vision Open
Objective Patients with the photovoltaic subretinal implant PRIMA demonstrated letter acuity by ~0.1 logMAR worse than the sampling limit for 100μm pixels (1.3 logMAR) and performed slower than healthy subjects, which exceeded the sampling…
View article: Performance of complex visual tasks using simulated prosthetic vision via augmented-reality glasses
Performance of complex visual tasks using simulated prosthetic vision via augmented-reality glasses Open
Photovoltaic subretinal prosthesis is designed for restoration of central vision in patients with age-related macular degeneration (AMD). We investigated the utility of prosthetic central vision for complex visual tasks using augmented-rea…
View article: Characteristics of prosthetic vision in rats with subretinal flat and pillar electrode arrays
Characteristics of prosthetic vision in rats with subretinal flat and pillar electrode arrays Open
Objective . Retinal prostheses aim to restore sight by electrically stimulating the surviving retinal neurons. In clinical trials of the current retinal implants, prosthetic visual acuity does not exceed 20/550. However, to provide meaning…
View article: Honeycomb-shaped electro-neural interface enables cellular-scale pixels in subretinal prosthesis
Honeycomb-shaped electro-neural interface enables cellular-scale pixels in subretinal prosthesis Open
High-resolution visual prostheses require small, densely packed pixels, but limited penetration depth of the electric field formed by a planar electrode array constrains such miniaturization. We present a novel honeycomb configuration of a…
View article: Performance of Complex Visual Tasks using Simulated Prosthetic Vision via Augmented-Reality Glasses
Performance of Complex Visual Tasks using Simulated Prosthetic Vision via Augmented-Reality Glasses Open
Purpose Photovoltaic subretinal prosthesis is designed for restoration of central vision in patients with age-related macular degeneration (AMD). We investigated the utility of prosthetic central vision for complex visual tasks using augme…
View article: Temporal structure in spiking patterns of ganglion cells defines perceptual thresholds in rodents with subretinal prosthesis
Temporal structure in spiking patterns of ganglion cells defines perceptual thresholds in rodents with subretinal prosthesis Open
Subretinal prostheses are designed to restore sight in patients blinded by retinal degeneration using electrical stimulation of the inner retinal neurons. To relate retinal output to perception, we studied behavioral thresholds in blind ra…
View article: Spatiotemporal characteristics of retinal response to network-mediated photovoltaic stimulation
Spatiotemporal characteristics of retinal response to network-mediated photovoltaic stimulation Open
Subretinal prostheses aim at restoring sight to patients blinded by photoreceptor degeneration using electrical activation of the surviving inner retinal neurons. Today, such implants deliver visual information with low-frequency stimulati…
View article: Behavioral assessment of photovoltaic subretinal prosthesis in rats with retinal degeneration
Behavioral assessment of photovoltaic subretinal prosthesis in rats with retinal degeneration Open
View article: Retinal spatiotemporal characteristics and contrast sensitivity with subretinal prosthesis
Retinal spatiotemporal characteristics and contrast sensitivity with subretinal prosthesis Open
View article: Spatio-temporal characteristics of retinal responses to subretinal photovoltaic stimulation
Spatio-temporal characteristics of retinal responses to subretinal photovoltaic stimulation Open