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View article: Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality
Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality Open
View article: Efficient timed mating and early pregnancy detection in guinea pigs v1
Efficient timed mating and early pregnancy detection in guinea pigs v1 Open
Guinea pigs have served as valuable animal models for various research questions. The structural similarity of the guinea pig placenta to the human placenta, particularly its hemomonochorial organization, supports its use in reproductive a…
View article: Kupffer cell programming by maternal obesity triggers fatty liver disease
Kupffer cell programming by maternal obesity triggers fatty liver disease Open
View article: Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism
Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism Open
Plastic pollution is an emerging yet understudied environmental risk to the immune system. Once ingested, nano- and microplastic particles (MNPs) can translocate from the gut to internal organs, with macrophages serving as primary targets.…
View article: Kupffer cells control neonatal hepatic metabolism via Igf1 signaling
Kupffer cells control neonatal hepatic metabolism via Igf1 signaling Open
During perinatal development, liver metabolism is tightly regulated to ensure energy supply for the newborn. Before birth, glycogen is stored in hepatocytes and later metabolized to glucose, meeting the energy demands of the neonate. Short…
View article: CD163 Expression Defines a Red Pulp Macrophage Subset Engaged in Crosstalk with Marginal Metallophilic Macrophages During Blood-Stage Malaria
CD163 Expression Defines a Red Pulp Macrophage Subset Engaged in Crosstalk with Marginal Metallophilic Macrophages During Blood-Stage Malaria Open
View article: cOmicsArt—a customizable Omics Analysis and reporting tool
cOmicsArt—a customizable Omics Analysis and reporting tool Open
Motivation The availability of bulk-omic data is steadily increasing, necessitating collaborative efforts between experimental and computational researchers. While software tools with graphical user interfaces (GUIs) enable rapid and inter…
View article: CD226<sup>+</sup>adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism
CD226<sup>+</sup>adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism Open
Macrophages are innate immune cells present in all tissues, in which they participate in immune responses and maintenance of tissue homeostasis. They develop either from embryonic precursors or from circulating monocytes, and their functio…
View article: Developmental programming of tissue-resident macrophages
Developmental programming of tissue-resident macrophages Open
Macrophages are integral components of the innate immune system that colonize organs early in development and persist into adulthood through self-renewal. Their fate, whether they are replaced by monocytes or retain their embryonic origin,…
View article: cOmicsArt – a customizable Omics Analysis and reporting tool
cOmicsArt – a customizable Omics Analysis and reporting tool Open
Motivation The availability of bulk-omic data is steadily increasing, necessitating collaborative efforts between experimental and computational researchers. While software tools with graphical user interfaces (GUIs) enable rapid and inter…
View article: Disease-associated microglia and activation of CD8<sup>+</sup>T cells precede neuronal cell loss in a model of hereditary spastic paraplegia
Disease-associated microglia and activation of CD8<sup>+</sup>T cells precede neuronal cell loss in a model of hereditary spastic paraplegia Open
In central nervous system (CNS) diseases characterized by late-onset neurodegeneration, the interplay between innate and adaptive immune responses remains poorly understood. This knowledge gap is amplified by the prolonged nature of these …
View article: Identification of a mesodermal progenitor for the pro-definitive angio-hematopoietic lineage
Identification of a mesodermal progenitor for the pro-definitive angio-hematopoietic lineage Open
Mammalian hematopoietic cells arise from mesodermal progenitors in a close developmental relationship with endothelium, and along three distinct cell lineages known as primitive, pro-definitive, and definitive hematopoiesis. However, the d…
View article: From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists
From Planning Stage Towards FAIR Data: A Practical Metadatasheet For Biomedical Scientists Open
Datasets consist of measurement data and metadata. Metadata provides context, essential for understanding and (re-)using data. Various metadata standards exist for different methods, systems and contexts. However, relevant information resi…
View article: Author response: Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis
Author response: Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis Open
Full text Figures and data Peer review Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract During embryogenesis, the f…
View article: From Planning Stage To FAIR Data: A Practical Metadatasheet For Biomedical Scientists
From Planning Stage To FAIR Data: A Practical Metadatasheet For Biomedical Scientists Open
Datasets consist of measurement data and metadata. Metadata provides context, essential for understanding and (re-)using data. Various metadata standards exist for different methods, systems and contexts. However, relevant information resi…
View article: BBSome-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue
BBSome-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue Open
The primary cilium has emerged as critical in regulating whole-body energy metabolism, as reflected in the Bardet-Biedl syndrome (BBS), where primary cilia dysfunction leads to obesity due to hyperphagia and white adipose tissue (WAT) remo…
View article: Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair
Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair Open
Tissue repair after myocardial infarction (MI) is guided by autocrine and paracrine-acting proteins. Deciphering these signals and their upstream triggers is essential when considering infarct healing as a therapeutic target. Here we perfo…
View article: Differential impact of high-salt levels in vitro and in vivo on macrophage core functions
Differential impact of high-salt levels in vitro and in vivo on macrophage core functions Open
The consumption of processed food is on the rise leading to huge intake of excess dietary salt, which strongly correlates with development of hypertension, often leading to cardiovascular diseases such as stroke and heart attack, as well a…
View article: Our plastic world – what does it mean for our health?
Our plastic world – what does it mean for our health? Open
Our plastic world – what does it mean for our health? The interdisciplinary ERC Starting Grant project “Understanding the impact of nanoplastics on the development of neurological disorders (NanoGlia)” studies how plastic particles activat…
View article: Developmental programming of Kupffer cells by maternal obesity causes fatty liver disease in the offspring
Developmental programming of Kupffer cells by maternal obesity causes fatty liver disease in the offspring Open
Kupffer cells (KCs) are tissue-resident macrophages which colonize the developing liver early during embryogenesis 1 . Throughout development and adulthood, KCs have distinct core functions that are essential for liver and organ…
View article: The stunning clodronate
The stunning clodronate Open
Not only macrophages, but also neutrophils, are a main target of clodronate. In this issue of JEM, Culemann et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20220525) demonstrate that anti-inflammatory effects of clodronate liposomes …
View article: Tissue-specific macrophages: how they develop and choreograph tissue biology
Tissue-specific macrophages: how they develop and choreograph tissue biology Open
Macrophages are innate immune cells that form a 3D network in all our tissues, where they phagocytose dying cells and cell debris, immune complexes, bacteria and other waste products. Simultaneously, they produce growth factors and signall…
View article: Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis
Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis Open
During embryogenesis, the fetal liver becomes the main hematopoietic organ, where stem and progenitor cells as well as immature and mature immune cells form an intricate cellular network. Hematopoietic stem cells (HSCs) reside in a special…
View article: This record contains raw data related to the article "Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis"
This record contains raw data related to the article "Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis" Open
This record contains raw data related to the article "Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis" Background: Aortic stenosis (AS) is the most common valve disorder charact…
View article: This record contains raw data related to the article "Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis"
This record contains raw data related to the article "Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis" Open
This record contains raw data related to the article "Sex-Specific Cell Types and Molecular Pathways Indicate Fibro-Calcific Aortic Valve Stenosis" Background: Aortic stenosis (AS) is the most common valve disorder charact…
View article: GPR183 targets lung-resident CD301b<sup>+</sup> conventional dendritic cells type 2 to a subtissular TSLP – TSLP receptor mediated survival niche within the adventital cuff
GPR183 targets lung-resident CD301b<sup>+</sup> conventional dendritic cells type 2 to a subtissular TSLP – TSLP receptor mediated survival niche within the adventital cuff Open
Summary Conventional dendritic cells (cDCs) are strategically localized throughout non-lymphoid tissues. How such spatially regulated subtissular placement is achieved remains largely elusive. Here, we reveal that GPR183 targets CD301b + c…
View article: Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model
Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model Open
Aims Degenerative mitral valve dystrophy (MVD) leading to mitral valve prolapse is the most frequent form of MV disease, and there is currently no pharmacological treatment available. The limited understanding of the pathophysiological mec…
View article: Red Blood Cell Distribution Width to Platelet Count Ratio Facilitates Preoperative Prediction of Recurrence in Surgically Treated Chronic Subdural Hematoma
Red Blood Cell Distribution Width to Platelet Count Ratio Facilitates Preoperative Prediction of Recurrence in Surgically Treated Chronic Subdural Hematoma Open
Graphical Abstract
View article: Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation
Author Correction: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation Open
View article: GPR183 Targets Lung-Resident CD301b <sup>+</sup> Conventional Dendritic Cells Type 2 to a Subtissular TSLP – TSLP Receptor Mediated Survival Niche Within the Adventitial Cuff
GPR183 Targets Lung-Resident CD301b <sup>+</sup> Conventional Dendritic Cells Type 2 to a Subtissular TSLP – TSLP Receptor Mediated Survival Niche Within the Adventitial Cuff Open