Elwyn Chomba
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View article: Effects of a single oral dose of azithromycin in laboring women on antimicrobial resistance (AMR) and the microbiome: a protocol for the Antimicrobial Resistance Sub-Study of the A-PLUS trial
Effects of a single oral dose of azithromycin in laboring women on antimicrobial resistance (AMR) and the microbiome: a protocol for the Antimicrobial Resistance Sub-Study of the A-PLUS trial Open
Background The Azithromycin Prevention in Labor Use Study (A-PLUS), a large, multi-national randomized trial, was performed to evaluate the improvement of maternal and newborn outcomes following a single dose of azithromycin (AZ) given dur…
View article: Health care in pregnancy during the COVID‐19 pandemic and pregnancy outcomes in six low‐ and‐middle‐income countries: Evidence from a prospective, observational registry of the Global Network for Women’s and Children’s Health
Health care in pregnancy during the COVID‐19 pandemic and pregnancy outcomes in six low‐ and‐middle‐income countries: Evidence from a prospective, observational registry of the Global Network for Women’s and Children’s Health Open
OBJECTIVE: To assess, on a population basis, the medical care for pregnant women in specific geographic regions of six countries before and during the first year of the coronavirus disease 2019 (COVID-19) pandemic in relationship to pregna…
View article: Knowledge, attitude and practices of pregnant women related to COVID‐19 infection: A cross‐sectional survey in seven countries from the Global Network for Women's and Children's Health
Knowledge, attitude and practices of pregnant women related to COVID‐19 infection: A cross‐sectional survey in seven countries from the Global Network for Women's and Children's Health Open
Objective: We sought to understand knowledge, attitudes and practices (KAP) regarding COVID-19 in pregnant women in seven low and middle-income countries (LMIC). Design: Population-based prospective, observational study. Settings: Study si…
View article: Cost-effectiveness of intrapartum azithromycin to prevent maternal infection, sepsis, or death in low-income and middle-income countries: a modelling analysis of data from a randomised, multicentre, placebo-controlled trial
Cost-effectiveness of intrapartum azithromycin to prevent maternal infection, sepsis, or death in low-income and middle-income countries: a modelling analysis of data from a randomised, multicentre, placebo-controlled trial Open
Eunice Kennedy Shriver National Institute of Child Health and Human Development and the Foundation for the National Institutes of Health through the Maternal, Newborn, and Child Health Discovery and Tools Initiative of the Bill & Melinda G…
View article: Effectiveness of intrapartum azithromycin to prevent infections in planned vaginal births in low-income and middle-income countries: a post-hoc analysis of data from a multicentre, randomised, double-blind, placebo-controlled trial
Effectiveness of intrapartum azithromycin to prevent infections in planned vaginal births in low-income and middle-income countries: a post-hoc analysis of data from a multicentre, randomised, double-blind, placebo-controlled trial Open
For the French and Spanish translations of the abstract see Supplementary Materials section.
View article: COVID‐19 antibody positivity over time and pregnancy outcomes in seven low‐and‐middle‐income countries: A prospective, observational study of the Global Network for Women's and Children's Health Research
COVID‐19 antibody positivity over time and pregnancy outcomes in seven low‐and‐middle‐income countries: A prospective, observational study of the Global Network for Women's and Children's Health Research Open
OBJECTIVES: To determine COVID-19 antibody positivity rates over time and relationships to pregnancy outcomes in low- and middle-income countries (LMICs). DESIGN: With COVID-19 antibody positivity at delivery as the exposure, we performed …
View article: Neurodevelopment of Children Whose Mothers Were Randomized to Low-Dose Aspirin During Pregnancy
Neurodevelopment of Children Whose Mothers Were Randomized to Low-Dose Aspirin During Pregnancy Open
OBJECTIVE: Because low-dose aspirin is now commonly prescribed in pregnancy, we sought to assess the association between early antenatal exposure and child neurodevelopment. METHODS: We performed a noninferiority, masked, neurodevelopmenta…
View article: Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo
Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo Open
Background Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes. Methods In a convenience sample of women from the ASPIRIN (Aspirin …
View article: Corrigendum to The impact of risk factors on aspirin's efficacy for the prevention of preterm birth. American Journal of Obstetrics & Gynecology MFM. Volume 5, Issue 10, October 2023, 101095
Corrigendum to The impact of risk factors on aspirin's efficacy for the prevention of preterm birth. American Journal of Obstetrics & Gynecology MFM. Volume 5, Issue 10, October 2023, 101095 Open
View article: The impact of risk factors on aspirin's efficacy for the prevention of preterm birth
The impact of risk factors on aspirin's efficacy for the prevention of preterm birth Open
BACKGROUND: The Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas trial was a landmark study that demonstrated a reduction in preterm birth and hypertensive disorders of pregnancy in nulliparous women who receive…
View article: Effects of a single oral dose of azithromycin in laboring women on antimicrobial resistance (AMR) and the microbiome: a protocol for the Antimicrobial Resistance Sub-Study of the A-PLUS trial
Effects of a single oral dose of azithromycin in laboring women on antimicrobial resistance (AMR) and the microbiome: a protocol for the Antimicrobial Resistance Sub-Study of the A-PLUS trial Open
Background The Azithromycin Prevention in Labor Use Study (A-PLUS), a large, multi-national randomized trial, was performed to evaluate the improvement of maternal and newborn outcomes following a single dose of azithromycin (AZ) given du…
View article: Intrapartum and postpartum antibiotic use in seven low‐ and middle‐income countries: Findings from the A‐PLUS trial
Intrapartum and postpartum antibiotic use in seven low‐ and middle‐income countries: Findings from the A‐PLUS trial Open
Objective To describe the intrapartum and postpartum use of non‐study antibiotics in low‐ and middle‐income countries (LMICs) during the double‐blinded NICHD Global Network Azithromycin in Labor (A‐PLUS) trial. Design The antibiotic use su…
View article: Junk food use and neurodevelopmental and growth outcomes in infants in low-resource settings
Junk food use and neurodevelopmental and growth outcomes in infants in low-resource settings Open
Introduction Feeding infants a sub-optimal diet deprives them of critical nutrients for their physical and cognitive development. The objective of this study is to describe the intake of foods of low nutritional value (junk foods) and iden…
View article: Junk food use and neurodevelopmental and growth outcomes in infants in low-resource settings
Junk food use and neurodevelopmental and growth outcomes in infants in low-resource settings Open
Introduction Feeding infants a sub-optimal diet deprives them of critical nutrients for their physical and cognitive development. The objective of this study is to describe the intake of foods of low nutritional value (junk foods) and iden…
View article: Corrigendum to The impact of risk factors on aspirin's efficacy for the prevention of preterm birth. American Journal of Obstetrics & Gynecology MFM. Volume 5, Issue 10, October 2023, 101095
Corrigendum to The impact of risk factors on aspirin's efficacy for the prevention of preterm birth. American Journal of Obstetrics & Gynecology MFM. Volume 5, Issue 10, October 2023, 101095 Open
View article: Neurodevelopment of Children Whose Mothers Were Randomized to Low-Dose Aspirin During Pregnancy
Neurodevelopment of Children Whose Mothers Were Randomized to Low-Dose Aspirin During Pregnancy Open
OBJECTIVE: Because low-dose aspirin is now commonly prescribed in pregnancy, we sought to assess the association between early antenatal exposure and child neurodevelopment. METHODS: We performed a noninferiority, masked, neurodevelopmenta…
View article: Neonatal Respiratory Support Utilization in Low- and Middle-Income Countries: A Registry-Based Observational Study
Neonatal Respiratory Support Utilization in Low- and Middle-Income Countries: A Registry-Based Observational Study Open
Background: Newborns with hypoxemia often require life-saving respiratory support. In low-resource settings, it is unknown if respiratory support is delivered more frequently to term infants or preterm infants. We hypothesize…
View article: Maternal age extremes and adverse pregnancy outcomes in low-resourced settings
Maternal age extremes and adverse pregnancy outcomes in low-resourced settings Open
Introduction Adolescent (<20 years) and advanced maternal age (>35 years) pregnancies carry adverse risks and warrant a critical review in low- and middle-income countries where the burden of adverse pregnancy outcomes is highest. Ob…
View article: AJOG MFM Table of Contents
AJOG MFM Table of Contents Open
View article: Can the date of last menstrual period be trusted in the first trimester? Comparisons of gestational age measures from a prospective cohort study in six low-income to middle-income countries
Can the date of last menstrual period be trusted in the first trimester? Comparisons of gestational age measures from a prospective cohort study in six low-income to middle-income countries Open
Objectives We examined gestational age (GA) estimates for live and still births, and prematurity rates based on last menstrual period (LMP) compared with ultrasonography (USG) among pregnant women at seven sites in six low-resource countri…
View article: Building a predictive model of low birth weight in low- and middle-income countries: a prospective cohort study
Building a predictive model of low birth weight in low- and middle-income countries: a prospective cohort study Open
View article: Trends over time in the knowledge, attitude and practices of pregnant women related to <scp>COVID</scp>‐19: A cross‐sectional survey from seven low‐ and middle‐income countries
Trends over time in the knowledge, attitude and practices of pregnant women related to <span>COVID</span>‐19: A cross‐sectional survey from seven low‐ and middle‐income countries Open
Objective To understand trends in the knowledge, attitudes and practices (KAP) of pregnant women related to COVID‐19 in seven low‐ and middle‐income countries. Design Multi‐country population‐based prospective observational study. Setting …
View article: The impact of risk factors on aspirin's efficacy for the prevention of preterm birth
The impact of risk factors on aspirin's efficacy for the prevention of preterm birth Open
View article: Prevention of maternal and neonatal death/infections with a single oral dose of azithromycin in women in labour in low-income and middle-income countries (A-PLUS): a study protocol for a multinational, randomised placebo-controlled clinical trial
Prevention of maternal and neonatal death/infections with a single oral dose of azithromycin in women in labour in low-income and middle-income countries (A-PLUS): a study protocol for a multinational, randomised placebo-controlled clinical trial Open
Introduction Maternal and neonatal infections are among the most frequent causes of maternal and neonatal mortality, and current antibiotic strategies have been ineffective in preventing many of these deaths. A randomised clinical trial co…
View article: Aspirin delays the onset of hypertensive disorders of pregnancy among nulliparous pregnant women: A secondary analysis of the <scp>ASPIRIN</scp> trial
Aspirin delays the onset of hypertensive disorders of pregnancy among nulliparous pregnant women: A secondary analysis of the <span>ASPIRIN</span> trial Open
Objective To assess the impact of low‐dose aspirin (LDA) starting in early pregnancy on delaying preterm hypertensive disorders of pregnancy. Design Non‐prespecified secondary analysis of a randomised masked trial of LDA. Setting The study…
View article: COVID‐19 symptoms and antibody positivity among unvaccinated pregnant women: An observational study in seven countries from the Global Network
COVID‐19 symptoms and antibody positivity among unvaccinated pregnant women: An observational study in seven countries from the Global Network Open
Objective To determine the relation of COVID‐19 symptoms to COVID‐19 antibody positivity among unvaccinated pregnant women in low‐ and middle‐income countries (LMIC). Design COVID‐19 infection status measured by antibody positivity at deli…
View article: Azithromycin in labour to reduce maternal and newborn sepsis and associated deaths: the need for a harmonized approach
Azithromycin in labour to reduce maternal and newborn sepsis and associated deaths: the need for a harmonized approach Open
Maternal and newborn infections are a major contributor to mortality and morbidity globally. Lost-cost, effective and safe interventions are needed to address these. Based on promising findings, azithromycin has been identified as potentia…
View article: Diagnostic accuracy of ASQ for screening of neurodevelopmental delays in low resource countries
Diagnostic accuracy of ASQ for screening of neurodevelopmental delays in low resource countries Open
Objective The Bayley Scales of Infant Development (BSID) is the most used diagnostic tool to identify neurodevelopmental disorders in children under age 3 but is challenging to use in low-resource countries. The Ages and Stages Questionnai…
View article: Cost-effectiveness of low-dose aspirin for the prevention of preterm birth: a prospective study of the Global Network for Women's and Children's Health Research
Cost-effectiveness of low-dose aspirin for the prevention of preterm birth: a prospective study of the Global Network for Women's and Children's Health Research Open
View article: Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth
Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth Open
Among women planning a vaginal delivery, a single oral dose of azithromycin resulted in a significantly lower risk of maternal sepsis or death than placebo but had little effect on newborn sepsis or death. (Funded by the Eunice Kennedy Shr…