Elzbieta Gralinska
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View article: Hepatocyte differentiation requires anisotropic expansion of bile canaliculi
Hepatocyte differentiation requires anisotropic expansion of bile canaliculi Open
During liver development, bipotential progenitor cells called hepatoblasts differentiate into hepatocytes or cholangiocytes. Hepatocyte differentiation is uniquely associated with multi-axial polarity, enabling the anisotropic expansion of…
View article: Hepatocyte differentiation requires anisotropic expansion of bile canaliculi
Hepatocyte differentiation requires anisotropic expansion of bile canaliculi Open
During liver development, bipotential progenitor cells called hepatoblasts differentiate into hepatocytes or cholangiocytes. Hepatocyte differentiation is uniquely associated with multi-axial polarity, enabling the anisotropic expansion of…
View article: Association Plots: visualizing cluster-specific associations in high-dimensional correspondence analysis biplots
Association Plots: visualizing cluster-specific associations in high-dimensional correspondence analysis biplots Open
In molecular biology, just as in many other fields of science, data often come in the form of matrices or contingency tables with many observations (rows) for a set of variables (columns). While projection methods like principal component …
View article: Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells
Enhanced cortical neural stem cell identity through short SMAD and WNT inhibition in human cerebral organoids facilitates emergence of outer radial glial cells Open
Cerebral organoids exhibit broad regional heterogeneity accompanied by limited cortical cellular diversity despite the tremendous upsurge in derivation methods, suggesting inadequate patterning of early neural stem cells (NSCs). Here we sh…
View article: Visualizing Cluster-specific Genes from Single-cell Transcriptomics Data Using Association Plots
Visualizing Cluster-specific Genes from Single-cell Transcriptomics Data Using Association Plots Open
Visualizing single-cell transcriptomics data in an informative way is a major challenge in biological data analysis. Clustering of cells is a prominent analysis step and the results are usually visualized in a planar embedding of the cells…
View article: Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads
Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads Open
Lumen morphogenesis results from the interplay between molecular pathways and mechanical forces. In several organs, epithelial cells share their apical surfaces to form a tubular lumen. In the liver, however, hepatocytes share the apical s…
View article: Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads
Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads Open
Lumen morphogenesis is key to the function of organs and results from the integration of molecular pathways and mechanical forces 1–3 . The mechanisms governing anisotropic lumen expansion remain elusive 4–6 . In contrast to epithelial cel…
View article: Association Plots: Visualizing associations in high-dimensional correspondence analysis biplots
Association Plots: Visualizing associations in high-dimensional correspondence analysis biplots Open
S ummary In molecular biology, just as in many other fields of science, data often come in the form of matrices or contingency tables with many measurements (rows) for a set of variables (columns). While projection methods like Principal C…