Emanuela Brunetto
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View article: Spitz Spindle Cell/Reed Nevus With <scp><i>SQSTM1</i></scp>::<scp><i>NTRK2</i></scp> Fusion and Atypical Features in an Older Male Patient: A Case Report and Review of Literature
Spitz Spindle Cell/Reed Nevus With <span><i>SQSTM1</i></span>::<span><i>NTRK2</i></span> Fusion and Atypical Features in an Older Male Patient: A Case Report and Review of Literature Open
Spitz lesions display a set of genetic alterations that differ from classical melanocytic lesions: examples include mutations in HRAS and fusions involving ALK , ROS1 , MET , MAP3K8 , BRAF , and the NTRK genes. We present a Spitz spindle c…
View article: Epithelial ovarian cancer is infiltrated by activated effector T cells co-expressing CD39, PD-1, TIM-3, CD137 and interacting with cancer cells and myeloid cells
Epithelial ovarian cancer is infiltrated by activated effector T cells co-expressing CD39, PD-1, TIM-3, CD137 and interacting with cancer cells and myeloid cells Open
Introduction Despite predicted efficacy, immunotherapy in epithelial ovarian cancer (EOC) has limited clinical benefit and the prognosis of patients remains poor. There is thus a strong need for better identifying local immune dynamics and…
View article: Gene Fusion Detection in NSCLC Routine Clinical Practice: Targeted-NGS or FISH?
Gene Fusion Detection in NSCLC Routine Clinical Practice: Targeted-NGS or FISH? Open
The ability to identify the broadest range of targetable gene fusions is crucial to facilitate personalized therapy selection for advanced lung adenocarcinoma (LuADs) patients harboring targetable receptor tyrosine kinase (RTK) genomic alt…
View article: Supplementary Table 1 from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients
Supplementary Table 1 from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients Open
Multivariate Cox regression analysis of the influence of the percentage of basophils in TDLNs on the survival of 35 stage IB-III pancreatic cancer patients after surgery.
View article: Supplementary Table 1 from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients
Supplementary Table 1 from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients Open
Multivariate Cox regression analysis of the influence of the percentage of basophils in TDLNs on the survival of 35 stage IB-III pancreatic cancer patients after surgery.
View article: Supplementary Figure 1 from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients
Supplementary Figure 1 from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients Open
Expression of CCL24/eotaxin-2 in CAF supernatant-conditioned monocytes and in TDLNs.
View article: Data from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients
Data from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients Open
In pancreatic ductal adenocarcinomas (PDAC), lymphoid infiltrates, comprised mainly of Th2 cells, predict a poor survival outcome in patients. IL4 signaling has been suggested to stabilize the Th2 phenotype in this setting, but the cellula…
View article: Data from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients
Data from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients Open
In pancreatic ductal adenocarcinomas (PDAC), lymphoid infiltrates, comprised mainly of Th2 cells, predict a poor survival outcome in patients. IL4 signaling has been suggested to stabilize the Th2 phenotype in this setting, but the cellula…
View article: Supplementary Figure 1 from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients
Supplementary Figure 1 from Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients Open
Expression of CCL24/eotaxin-2 in CAF supernatant-conditioned monocytes and in TDLNs.
View article: Locally Performed HRD Testing for Ovarian Cancer? Yes, We Can!
Locally Performed HRD Testing for Ovarian Cancer? Yes, We Can! Open
Assessment of HRD status is now essential for ovarian cancer patient management. A relevant percentage of high-grade serous carcinoma (HGSC) is characterized by HRD, which is caused by genetic alterations in the homologous recombination re…
View article: 2022-RA-1651-ESGO Epithelial Ovarian Cancer is infiltrated by activated effector T cells coexpressing multiple inhibitory receptors and by myeloid cells expressing inhibitory receptor ligands
2022-RA-1651-ESGO Epithelial Ovarian Cancer is infiltrated by activated effector T cells coexpressing multiple inhibitory receptors and by myeloid cells expressing inhibitory receptor ligands Open
Introduction/Background Despite evidence suggesting a potential role for immunotherapy in Epithelial Ovarian Cancer (EOC), initial attempts had limited efficacy. A better characterization of tumor infiltrating lymphocytes' (TIL) immunophen…
View article: The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer
The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer Open
Our findings indicate that tumor released IL-1α and IL-1β and ASC are key regulators of TSLP secretion by CAFs and their targeting should ultimately dampen Th2 inflammation and improve overall survival in pancreatic cancer.
View article: Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients
Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients Open
In pancreatic ductal adenocarcinomas (PDAC), lymphoid infiltrates, comprised mainly of Th2 cells, predict a poor survival outcome in patients. IL4 signaling has been suggested to stabilize the Th2 phenotype in this setting, but the cellula…