Emanuela Medda
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View article: Assessment of Risk Factors for Cognitive Impairment Accounting for Genetic and Environmental Influences: An Italian Population-Based Twin Study
Assessment of Risk Factors for Cognitive Impairment Accounting for Genetic and Environmental Influences: An Italian Population-Based Twin Study Open
Background/Objectives: The etiology of dementia is complex and multifactorial, with both genetic and environmental factors contributing to its onset. The Lancet Commission has identified several risk factors for this condition, but it is i…
View article: Exploring intergenerational links and genetic correlates of metacognitive beliefs: A systematic review and meta-analysis
Exploring intergenerational links and genetic correlates of metacognitive beliefs: A systematic review and meta-analysis Open
Background Metacognitive beliefs, as proposed in the Self-Regulatory Executive Function (S-REF) model, are considered to play a central role in the development and maintenance of psychological disorders; however the intergenerational dimen…
View article: Sleep Quality, Pain, Worry, and Rumination in Fibromyalgia: Results from Mediation Analyses
Sleep Quality, Pain, Worry, and Rumination in Fibromyalgia: Results from Mediation Analyses Open
Background/Objectives: Fibromyalgia (FM) is a chronic pain syndrome frequently associated with severe pain, sleep disturbances, worry, and depressive rumination. Although previous studies have shown links among these factors, no study has …
View article: Psycho-Socio-Behavioural Substrates of Non-Cancer Chronic Pain: A Twin Study in Italian Adults
Psycho-Socio-Behavioural Substrates of Non-Cancer Chronic Pain: A Twin Study in Italian Adults Open
This study provides insights into the relationship of CP with depression, suggesting a quasi-causal connection between them, an important contribution of unique environmental factors in this connection, and a mediating role of sleep qualit…
View article: Chronic Pain Prevalence and Psychosocial Burden in the Italian Population from the 2019 European Health Interview Survey
Chronic Pain Prevalence and Psychosocial Burden in the Italian Population from the 2019 European Health Interview Survey Open
Chronic pain (CP) is a global healthcare concern requiring careful monitoring. In Italy, the most recent CP prevalence estimates date back to 2003. In this work, we analyzed data from the 2019 European Health Interview Survey, based on a r…
View article: Exploring the Relationship of Cognitive Disengagement Syndrome and Attention Deficit/Hyperactivity Disorder with Emotional Dysregulation: A Twin Study in Childhood and Adolescence
Exploring the Relationship of Cognitive Disengagement Syndrome and Attention Deficit/Hyperactivity Disorder with Emotional Dysregulation: A Twin Study in Childhood and Adolescence Open
Data on the genetic and environmental factors underlying the co-occurrence of Cognitive Disengagement Syndrome (CDS), Attention Deficit Hyperactivity Disorder (ADHD), and Emotional Dysregulation (ED) are limited. This study aimed to explor…
View article: Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts
Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts Open
Introduction Genetic factors contribute to weight gain, but how these effects change over adulthood is still unknown. We studied the impact of genetics on BMI change from young adulthood to old age and its relationship with BMI in early yo…
View article: Exploring the comorbidity between internalizing/externalizing dimensions and cognitive disengagement syndrome through twin studies: a narrative review
Exploring the comorbidity between internalizing/externalizing dimensions and cognitive disengagement syndrome through twin studies: a narrative review Open
Twin studies are cutting-edge design methodologies proper to behavioral genetics that aim to investigate how the interplay between genetic and environmental factors can concur to explain individual differences in psychopathology, temperame…
View article: Investigating Genetic and Environmental Substrates of the Relationship between Positive Mental Health and Biological Aging—A Study Protocol
Investigating Genetic and Environmental Substrates of the Relationship between Positive Mental Health and Biological Aging—A Study Protocol Open
Background: The Italian National Institute of Health (Istituto Superiore di Sanità) funded a 30-month project (July 2021–January 2024) to conduct a twin study of the relationships between Positive Mental Health (PMH) and cellular longevity…
View article: Connecting psychosocial and personality characteristics with mental health outcomes. An Italian co-twin control study
Connecting psychosocial and personality characteristics with mental health outcomes. An Italian co-twin control study Open
View article: Fifteen Years of Iodine Prophylaxis in Italy: Results of a Nationwide Surveillance (Period 2015-2019)
Fifteen Years of Iodine Prophylaxis in Italy: Results of a Nationwide Surveillance (Period 2015-2019) Open
Context In 2005, a nationwide program of iodine prophylaxis on a voluntary basis was implemented in Italy by law. However, recent data on iodine status are lacking. Objective The aim of this study was to evaluate efficiency, effectiveness,…
View article: Reduction in the use of green spaces during the COVID-19 pandemic and its impact on mental health
Reduction in the use of green spaces during the COVID-19 pandemic and its impact on mental health Open
Our study examined the use of green spaces before and during the pandemic in a large cohort of Italian twins and evaluated its impact on measures of mental health (depressive, anxiety, stress symptoms). Twins were analysed as individuals a…
View article: Stability and change in genetic and environmental influences on depressive symptoms in response to COVID-19 pandemic
Stability and change in genetic and environmental influences on depressive symptoms in response to COVID-19 pandemic Open
Background The rapid spread of the new Coronavirus and the consequent restrictions to contain transmission generated an unprecedented psychological impact on the general population. The Italian Twin Registry performed a longitudinal study …
View article: Age-Related Variations of Genetic and Environmental Contributions to the Covariation of Fear, Distress and Externalizing Symptoms: A Twin Study in Childhood and Adolescence
Age-Related Variations of Genetic and Environmental Contributions to the Covariation of Fear, Distress and Externalizing Symptoms: A Twin Study in Childhood and Adolescence Open
View article: Effects of COVID-19 vaccination on clinical outcomes in patients hospitalized in Internal Medicine during Omicron variant spreading.
Effects of COVID-19 vaccination on clinical outcomes in patients hospitalized in Internal Medicine during Omicron variant spreading. Open
All over the world, mass vaccination is playing a fundamental role in contrasting the novel coronavirus disease 2019 (COVID-19) pandemic.Clinical trials have demonstrated that vaccines are safe and effective in preventing severe disease an…
View article: Brain morphological alterations associated with vulnerability to psychopathology: a discordant twin 7T MRI study
Brain morphological alterations associated with vulnerability to psychopathology: a discordant twin 7T MRI study Open
View article: A multi-marker integrative analysis reveals benefits and risks of bariatric surgery
A multi-marker integrative analysis reveals benefits and risks of bariatric surgery Open
View article: An Italian Twin Study of Non-Cancer Chronic Pain as a Wide Phenotype and Its Intensity
An Italian Twin Study of Non-Cancer Chronic Pain as a Wide Phenotype and Its Intensity Open
Background and Objectives: Non-cancer chronic pain (CP) results from the interaction between genetic and environmental factors. Twin studies help to estimate genetic and environmental contributions to complex traits such as CP. To date, tw…
View article: Heritability and environmental influences on the onset of aortic valve sclerosis: a twin population study
Heritability and environmental influences on the onset of aortic valve sclerosis: a twin population study Open
Background Aortic valve sclerosis (AVSc) is the earliest manifestation of a life-threatening cardiovascular disorder, namely aortic valve stenosis (AS). AVSc is also recognized as a red flag linked to worse cardiovascular outcomes in high-…
View article: Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts
Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts Open
View article: Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood
Association of Assisted Reproductive Technology With Offspring Growth and Adiposity From Infancy to Early Adulthood Open
Importance: People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world's population. Objective: To investigate the association of ART conception with offspring growth and adiposity from infa…
View article: Development and Validation of the Italian “Brief Five-Item Chronic Pain Questionnaire” for Epidemiological Studies
Development and Validation of the Italian “Brief Five-Item Chronic Pain Questionnaire” for Epidemiological Studies Open
The designed questionnaire is a brief self-administered measure, particularly suitable to detect persistent states of pain and related intensity in large-scale general population surveys by means of a first filtering item followed by four …
View article: Development and Validation of the Italian “Brief Five-Item Chronic Pain Questionnaire” for Epidemiological Studies
Development and Validation of the Italian “Brief Five-Item Chronic Pain Questionnaire” for Epidemiological Studies Open
Virgilia Toccaceli,1 Michael Tenti,2 Maria Antonietta Stazi,1 Corrado Fagnani,1 Emanuela Medda,1 Lidia Gargiulo,3 Alessandra Burgio,3 Letizia Sampaolo,4 Maurizio Ferri,1 William Raffaeli2 1Centre for Behavioural Sciences and Mental Health,…
View article: Genetic and environmental contributions to psychopathological symptoms stability and change across the COVID-19 pandemic
Genetic and environmental contributions to psychopathological symptoms stability and change across the COVID-19 pandemic Open
View article: Inflammation, underweight, malignancy and a marked catabolic state as predictors for worse outcomes in COVID-19 patients with moderate-to-severe disease admitted to Internal Medicine Unit
Inflammation, underweight, malignancy and a marked catabolic state as predictors for worse outcomes in COVID-19 patients with moderate-to-severe disease admitted to Internal Medicine Unit Open
Introduction During COVID-19 pandemic, Internal Medicine Units (IMUs) accounted for about 70% of patients hospitalized. Although a large body of data has been published regarding the so-called first wave of the pandemic, little is known ab…
View article: Association of assisted reproductive technology with offspring growth and adiposity from infancy to early adulthood
Association of assisted reproductive technology with offspring growth and adiposity from infancy to early adulthood Open
Importance People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world’s population, and their numbers are expected to continue rising. Objective Investigate association of ART conception wit…
View article: Aggiornamento sulla nutrizione iodica in Italia: i risultati della seconda sorveglianza dell’Osservatorio per il Monitoraggio della Iodoprofilassi in Italia-OSNAMI (2015-2019)
Aggiornamento sulla nutrizione iodica in Italia: i risultati della seconda sorveglianza dell’Osservatorio per il Monitoraggio della Iodoprofilassi in Italia-OSNAMI (2015-2019) Open
View article: Association of long-term exposure to PM<sub>2.5</sub>with hypertension prevalence and blood pressure in China: a cross-sectional study
Association of long-term exposure to PM<sub>2.5</sub>with hypertension prevalence and blood pressure in China: a cross-sectional study Open
Objective Evidence of the effects of long-term fine particulate matter (PM 2.5 ) exposure on hypertension and blood pressure is limited for populations exposed to high levels of PM 2.5 . We aim to assess associations of long-term exposure …
View article: The COVID-19 pandemic in Italy: Depressive symptoms immediately before and after the first lockdown
The COVID-19 pandemic in Italy: Depressive symptoms immediately before and after the first lockdown Open
View article: Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts
Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts Open
Comparing twins from same- and opposite-sex pairs can provide information on potential sex differences in a variety of outcomes, including socioeconomic-related outcomes such as educational attainment. It has been suggested that this desig…