Emanuela Ricciotti
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View article: Sources of non-uniform coverage in short-read RNA-Seq data
Sources of non-uniform coverage in short-read RNA-Seq data Open
The origin of several normal cellular functions and related abnormalities can be traced back to RNA splicing. As such, RNA splicing is currently the focus of a vast array of studies. To quantify the transcriptome, short-read RNA-Seq remain…
View article: Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs
Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs Open
Non-steroidal anti-inflammatory drugs (NSAIDs) are popular choices for the mitigation of pain and inflammation; however, they are accompanied by side effects in the gastrointestinal and cardiovascular systems. We compared the effects of na…
View article: Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use
Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use Open
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used medications for the management of chronic pain; however, they are associated with numerous gastrointestinal (GI) adverse events. Although many mechanisms have been sugg…
View article: Suppression of cyclooxygenase-2 predisposes to heart failure with preserved ejection fraction
Suppression of cyclooxygenase-2 predisposes to heart failure with preserved ejection fraction Open
Heart failure (HF) is one of the most strongly associated adverse cardiovascular events linked to the use of cyclooxygenase (COX)-2 selective and non-selective nonsteroidal anti-inflammatory drug (NSAID). Nevertheless, it remains uncertain…
View article: Disruption of the PGE<sub>2</sub>synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice
Disruption of the PGE<sub>2</sub>synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice Open
Immune checkpoint inhibitors (ICIs) that target programmed cell death 1 (PD-1) have revolutionized cancer treatment by enabling the restoration of suppressed T-cell cytotoxic responses. However, resistance to single-agent ICIs limits their…
View article: Differential Impact In Vivo of Pf4-ΔCre–Mediated and Gp1ba-ΔCre–Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice
Differential Impact In Vivo of Pf4-ΔCre–Mediated and Gp1ba-ΔCre–Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice Open
BACKGROUND: Low-dose aspirin is widely used for the secondary prevention of cardiovascular disease. The beneficial effects of low-dose aspirin are attributable to its inhibition of platelet Cox (cyclooxygenase)-1–derived thromboxane A 2 . …
View article: Prostanoids in Cardiac and Vascular Remodeling
Prostanoids in Cardiac and Vascular Remodeling Open
Prostanoids are biologically active lipids generated from arachidonic acid by the action of the COX (cyclooxygenase) isozymes. NSAIDs, which reduce the biosynthesis of prostanoids by inhibiting COX activity, are effective anti-inflammatory…
View article: Deep phenotyping of the lipidomic response in COVID‐19 and non‐COVID‐19 sepsis
Deep phenotyping of the lipidomic response in COVID‐19 and non‐COVID‐19 sepsis Open
Background Lipids may influence cellular penetrance by viral pathogens and the immune response that they evoke. We deeply phenotyped the lipidomic response to SARs‐CoV‐2 and compared that with infection with other pathogens in patients adm…
View article: Editorial: Eicosanoids in cancer, Volume II
Editorial: Eicosanoids in cancer, Volume II Open
EDITORIAL article Front. Pharmacol., 14 June 2023Sec. Inflammation Pharmacology Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1224623
View article: Deep Phenotyping of the Lipidomic Response in COVID and non-COVID Sepsis
Deep Phenotyping of the Lipidomic Response in COVID and non-COVID Sepsis Open
Lipids may influence cellular penetrance by pathogens and the immune response that they evoke. Here we find a broad based lipidomic storm driven predominantly by secretory (s) phospholipase A 2 (sPLA 2 ) dependent eicosanoid production occ…
View article: Nonsteroidal anti-inflammatory drugs as a targeted therapy for bone marrow failure in Ghosal hematodiaphyseal dysplasia
Nonsteroidal anti-inflammatory drugs as a targeted therapy for bone marrow failure in Ghosal hematodiaphyseal dysplasia Open
Advances in genomic diagnostics hold promise for improved care of rare hematologic diseases. Here, we describe a novel targeted therapeutic approach for Ghosal hematodiaphyseal dysplasia, an autosomal recessive disease characterized by sev…
View article: Considerations for the Safe Operation of Schools During the Coronavirus Pandemic
Considerations for the Safe Operation of Schools During the Coronavirus Pandemic Open
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, providing safe in-person schooling has been a dynamic process balancing evolving community disease burden, scientific information, and local regulatory requi…
View article: Editorial: Eicosanoids in Cancer
Editorial: Eicosanoids in Cancer Open
EDITORIAL article Front. Pharmacol., 09 September 2021 | https://doi.org/10.3389/fphar.2021.765214
View article: Nonsteroidal anti-inflammatory drugs and glucocorticoids in COVID-19
Nonsteroidal anti-inflammatory drugs and glucocorticoids in COVID-19 Open
View article: Sex-dependent compensatory mechanisms preserve blood pressure homeostasis in prostacyclin receptor–deficient mice
Sex-dependent compensatory mechanisms preserve blood pressure homeostasis in prostacyclin receptor–deficient mice Open
Inhibitors of microsomal prostaglandin E synthase 1 (mPGES-1) are in the early phase of clinical development. Deletion of mPges-1 in mice confers analgesia, restrains atherogenesis, and fails to accelerate thrombogenesis, while suppressing…
View article: NSAID–Gut Microbiota Interactions
NSAID–Gut Microbiota Interactions Open
Nonsteroidal anti-inflammatory drugs (NSAID)s relieve pain, inflammation, and fever by inhibiting the activity of cyclooxygenase isozymes (COX-1 and COX-2). Despite their clinical efficacy, NSAIDs can cause gastrointestinal (GI) and cardio…
View article: Anti-Migratory Effects of 4′-Geranyloxyferulic Acid on LPS-Stimulated U937 and HCT116 Cells via MMP-9 Down-Regulation: Involvement of ROS/ERK Signaling Pathway
Anti-Migratory Effects of 4′-Geranyloxyferulic Acid on LPS-Stimulated U937 and HCT116 Cells via MMP-9 Down-Regulation: Involvement of ROS/ERK Signaling Pathway Open
Matrix metalloproteinases (MMPs) play a crucial role in tumor angiogenesis, and metastasis. 4′-geranyloxyferulic acid (GOFA) has anti-tumor and anti-inflammatory proprieties. Herein, we aimed to determine whether this compound affects cell…
View article: Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo
Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo Open
The inhibitor of human mPGES-1 AF3485 is a novel antiinflammatory compound which can also modulate COX-2 induction by inflammatory stimuli. The compound also induces endothelial COX-2-dependent PGI2 production via PPARγ a…
View article: Sex dependent compensatory mechanisms to preserve blood pressure homeostasis in PGI<sub>2</sub>receptor deficient mice
Sex dependent compensatory mechanisms to preserve blood pressure homeostasis in PGI<sub>2</sub>receptor deficient mice Open
Inhibitors of microsomal prostaglandin E synthase-1 (mPges-1) are in the early phase of clinical development. Deletion of mPges-1 confers analgesia, restrains atherogenesis and fails to accelerate thrombogenesis, while suppressing prostagl…
View article: LDL-mimetic lipid nanoparticles prepared by surface KAT ligation for<i>in vivo</i>MRI of atherosclerosis
LDL-mimetic lipid nanoparticles prepared by surface KAT ligation for<i>in vivo</i>MRI of atherosclerosis Open
LDL-mimetic lipid nanoparticles, decorated with MRI contrast agents and fluorescent dyes, were prepared by the covalent attachments of an apoB100-mimetic peptide, Gd(iii)-chelate, and rhodamine to enhance atherosclerosis in thein vivoimagi…
View article: Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input
Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input Open
View article: Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug Against H2O2-Induced Cellular Toxicity
Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug Against H2O2-Induced Cellular Toxicity Open
The L-3,4-dihydroxyphenylalanine (LD) is the gold standard drug currently used to manage Parkinson’s disease (PD) and to control its symptoms. However, LD could cause disease neurotoxicity due to the generation of pro-oxidant intermediates…
View article: Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium–Induced Colitis in Mice
Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium–Induced Colitis in Mice Open
View article: Distinct vascular genomic response of proton and gamma radiation—A pilot investigation
Distinct vascular genomic response of proton and gamma radiation—A pilot investigation Open
The cardiovascular biology of proton radiotherapy is not well understood. We aimed to compare the genomic dose-response to proton and gamma radiation of the mouse aorta to assess whether their vascular effects may diverge. We performed com…
View article: Distinct vascular genomic response of proton and gamma radiation
Distinct vascular genomic response of proton and gamma radiation Open
Purpose . The cardiovascular biology of proton radiotherapy is not well understood. We aimed to compare the genomic dose-response to proton and gamma radiation of the mouse aorta to assess whether their vascular effects may diverge. Materi…
View article: Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice
Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice Open
View article: ISO-RELEVANCE FUNCTIONS - A SYSTEMATIC APPROACH TO RANKING GENOMIC FEATURES BY DIFFERENTIAL EFFECT SIZE
ISO-RELEVANCE FUNCTIONS - A SYSTEMATIC APPROACH TO RANKING GENOMIC FEATURES BY DIFFERENTIAL EFFECT SIZE Open
It is common to measure large numbers of features to identify those differing between experimental conditions; for example using RNA-Seq to search for differentially expressed genes. Ranking by p-value allows for statistical control, but h…
View article: Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs
Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs Open
Background: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)–2, especia…
View article: COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer
COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer Open
View article: A comparison of Illumina and Ion Torrent sequencing platforms in the context of differential gene expression
A comparison of Illumina and Ion Torrent sequencing platforms in the context of differential gene expression Open
Taken together, our results indicate that while Illumina and Ion Torrent have similar capacities to detect changes in biology from a treatment/control experiment, these platforms may be tailored to interrogate different transcriptional phe…