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View article: Dynamics of Peripheral Lymphocyte Subsets from Birth until Old Age
Dynamics of Peripheral Lymphocyte Subsets from Birth until Old Age Open
The immune system is inexperienced before birth and tends to be tolerogenic, rather than immunogenic. After birth, the adaptive immune system develops while facing microbial challenges, but it can become impaired as old age progresses and …
View article: Altered Inflammasome and Immune activation in Paediatric Traumatic Brain Injury
Altered Inflammasome and Immune activation in Paediatric Traumatic Brain Injury Open
Introduction : Systemic Inflammation is associated with Traumatic Brain Injury (TBI) and therefore is a potential target for immunomodulation. Dysregulated immune function post-TBI increased susceptibility to infection and post-concussive …
View article: The relationship between physician burnout and depression, anxiety, suicidality and substance abuse: A mixed methods systematic review
The relationship between physician burnout and depression, anxiety, suicidality and substance abuse: A mixed methods systematic review Open
Introduction The World Health Organization defines burnout as a problem associated with employment, a category distinct from psychological disorders such as depression, anxiety, suicidality and disorders of substance abuse. Evaluating the …
View article: Mild To Severe Traumatic Brain Injury In Children: Altered Cytokines Reflect Severity
Mild To Severe Traumatic Brain Injury In Children: Altered Cytokines Reflect Severity Open
Background: Paediatric traumatic brain injury (TBI) is recognised to have significant longer–term neurocognitive effects. Childhood is a time of high risk for head injury. Functional recovery is variable with a combination of any or all of…
View article: Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy
Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy Open
We enumerated conventional and innate lymphocyte populations in neonates with neonatal encephalopathy (NE), school-age children post-NE, children with cerebral palsy and age-matched controls. Using flow cytometry, we demonstrate alteration…
View article: The utility of ketones at triage: a prospective cohort study
The utility of ketones at triage: a prospective cohort study Open
Objective To establish the relationship between serum point-of-care (POC) ketones at triage and moderate-to-severe dehydration based on the validated Gorelick Scales. Design, setting and patients Prospective unblinded study from April 2016…
View article: PAEDIATRIC OUTCOMES AND SERUM BIOMARKER PANEL IN ACUTE TRAUMATIC BRAIN INJURY /CONCUSSION TO SEVERE TRAUMATIC BRAIN INJURY
PAEDIATRIC OUTCOMES AND SERUM BIOMARKER PANEL IN ACUTE TRAUMATIC BRAIN INJURY /CONCUSSION TO SEVERE TRAUMATIC BRAIN INJURY Open
Introduction \nPaediatric mild traumatic brain injury (mTBI) is increasingly recognised to have significant longer term neurocognitive effects. Childhood is a time of high risk for head injury. There were no national guidelines for managem…
View article: Altered Toll-Like Receptor Signalling in Children with Down Syndrome
Altered Toll-Like Receptor Signalling in Children with Down Syndrome Open
Toll-like receptors (TLRs) are the key in initiating innate immune responses. TLR2 is crucial in recognising lipopeptides from gram-positive bacteria and is implicated in chronic inflammation. Children with Down syndrome (DS) are prone to …
View article: GP98 IL1- β levels at presentation with paediatric mild traumatic brain injury are higher in children with previous mild traumatic head injuries
GP98 IL1- β levels at presentation with paediatric mild traumatic brain injury are higher in children with previous mild traumatic head injuries Open
Aims To evaluate end components of the innate immune system, the inflammsome, in mild Traumatic Brain Injury (TBI), a pathway activated in mild tramatic brain injury and to correlate with previous exposure to head injury. Methods Whole blo…
View article: GP124 IL1- β levels at presentation correlate with symptom burden at 2 weeks in paediatric mild traumatic brain injury
GP124 IL1- β levels at presentation correlate with symptom burden at 2 weeks in paediatric mild traumatic brain injury Open
Aims To evaluate components of the innate immune system, the inflammsome, in mild Traumatic Brain Injury (TBI) and the correlation with symptom burden 2 weeks from injury. We examine activation of the pathway at presentation, and also at 2…
View article: GP123 Altered systemic inflammatory response in paediatric mild traumatic brain injury
GP123 Altered systemic inflammatory response in paediatric mild traumatic brain injury Open
Aims To evaluate systemic inflammation in TBI by exploration of the inflammasome pathway, a component of the innate immune system that regulates and induces inflammation. We examine the pathway at baseline in TBI compared with healthy cont…
View article: OC15 Paediatric mild traumatic brain injury is associated with systemic inflammasome activation and pubertal scoring
OC15 Paediatric mild traumatic brain injury is associated with systemic inflammasome activation and pubertal scoring Open
Background Mild Traumatic Brain Injury (mTBI) is a common childhood occurrence with a more severe phenotype in adolescence. Systemic inflammation has been demonstrated to be integral to the pathogenesis of ongoing symptoms. The inflammasom…
View article: OC33 Altered toll like receptor 2 (TLR2) signalling in children with down syndrome
OC33 Altered toll like receptor 2 (TLR2) signalling in children with down syndrome Open
Background Toll like receptors (TLRs) are key in initiating innate immune responses. TLR2 is crucial in recognising lipopeptides from gram positive bacteria and is implicated in chronic inflammation. Children with Down syndrome (DS) are pr…
View article: G349(P) Spectrum of paediatric traumatic brain injury presenting to tertiary paediatric emergency departments
G349(P) Spectrum of paediatric traumatic brain injury presenting to tertiary paediatric emergency departments Open
Aims To determine the burden and aetiology of traumatic brain injuries (TBIs) presenting to tertiary paediatric emergency departments (PEDs). To determine the number of TBIs that are symptomatic, requiring imaging, re-presenting and requir…
View article: Untreated chronic tuberculous salpingitis followed by successful<i>in vitro</i>fertilization conception and congenital tuberculosis
Untreated chronic tuberculous salpingitis followed by successful<i>in vitro</i>fertilization conception and congenital tuberculosis Open
### Learning Point for Clinicians
Female reproductive tract tuberculosis is rare in the developed world and its diagnosis is challenging. However, this case illustrates the importance of including female reproductive tract tuberculosis in…