Explanipedia

Targeted in vivo gene integration of a secretion-enabled GLP-1 receptor agonist reverses diet-induced non-genetic obesity and pre-diabetes Open

Jun Hirose, Emi Aizawa, Shogo Yamamoto, Shigenori Iwai, Keiichiro Suzuki · 2025

A case of osteonecrosis of the jaw with soft tissue necrosis due to osimertinib Open

Hirosaka Hayashi, Emi Aizawa, Chiaki Niho, Aoi Sakuyama, Hideki Watanabe , et al. · 2025

Lipid Nanoparticles Enable Efficient In Vivo DNA Knock-In via HITI-Mediated Genome Editing Open

Jun Hirose, Emi Aizawa, Shogo Yamamoto, Mingyao Xu, Shigenori Iwai , et al. · 2024

In vivo genome editing holds great therapeutic potential for treating monogenic diseases by enabling precise gene correction or addition. However, improving the efficiency of delivery systems remains a key challenge. In this study, we inve…

Optimization of an adeno-associated viral vector for epidermal keratinocytes in vitro and in vivo Open

Qi Shen, Shogo Suga, Yuta Moriwaki, Zening Du, Emi Aizawa , et al. · 2024

The combination of the AAVDJK2 capsid and K14 SCP3 promoter improves gene delivery to epidermis in vivo and KCs in vitro. The novel AAV system may benefit experimental research and development of new epidermis-targeted gene therapies.

Optimization of an adeno-associated viral vector for epidermal keratinocytes<i>in vitro</i>and<i>in vivo</i> Open

Qi Shen, Shogo Suga, Yuta Moriwaki, Du Zening, Emi Aizawa , et al. · 2024

Background: Local gene therapies, including in vivo genome editing, are highly anticipated for the treatment of genetic diseases in skin, especially the epidermis. While the adeno-associated virus (AAV) is a potent vector for in vivo gene …

Author Correction: Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing Open

Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos‐Mandujano, Mengge Wang , et al. · 2022

Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing Open

Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos‐Mandujano, Mengge Wang , et al. · 2022

The diverse functions of WASP, the deficiency of which causes Wiskott-Aldrich syndrome (WAS), remain poorly defined. We generated three isogenic WAS models using patient induced pluripotent stem cells and genome editing. These models recap…

Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy Open

Ryoko Kuwayama, Keiichiro Suzuki, Jun Nakamura, Emi Aizawa, Yoshichika Yoshioka , et al. · 2022

Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome Open

Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Emi Aizawa, Yoshiko Mizushina , et al. · 2022

Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflamm…

Author response: Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome Open

Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Emi Aizawa, Yoshiko Mizushina , et al. · 2022

Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome Open

Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Emi Aizawa, Yoshiko Mizushina , et al. · 2021

Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3, which was originally identified as cryopyrin. Familial cold autoinflammatory syndrome (FCAS), the mildest form of CAPS, is characte…

NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury Open

Homare Ito, Hiroaki Kimura, Tadayoshi Karasawa, Shu Hisata, Ai Sadatomo , et al. · 2020

Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to inflammation and remote organ damage. The NLRP3 inflammasome regulates the caspase-1–dependent release of IL-1β, an early mediator of inflammatio…

GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition Open

Emi Aizawa, Tadayoshi Karasawa, Sachiko Watanabe, Takanori Komada, Hiroaki Kimura , et al. · 2020

Pyroptosis is a form of regulated cell death that is characterized by gasdermin processing and increased membrane permeability. Caspase-1 and caspase-11 have been considered to be essential for gasdermin D processing associated with inflam…

Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction Open

Keiichiro Suzuki, Mako Yamamoto, Reyna Hernández‐Benítez, Zhe Li, Christopher Wei , et al. · 2019

Crucial Role of NLRP3 Inflammasome in the Development of Peritoneal Dialysis-related Peritoneal Fibrosis Open

Erika Hishida, Homare Ito, Takanori Komada, Tadayoshi Karasawa, Hiroaki Kimura , et al. · 2019

Long-term peritoneal dialysis (PD) therapy leads to peritoneal inflammation and fibrosis. However, the mechanism underlying PD-related peritoneal inflammation and fibrosis remains unclear. NLRP3 inflammasome regulates the caspase-1-depende…

Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network Open

Jian Hui Low, Pin Li, Elaine Guo Yan Chew, Bing‐Rui Zhou, Keiichiro Suzuki , et al. · 2019

Wiskott-Aldrich Syndrome Protein Regulates Nuclear Organization, Alternative Splicing and Cell Proliferation Open

Mo Li, Keiichiro Suzuki, Xuan Zhou, Takayoshi Yamauchi, James J. Moresco , et al. · 2018

Interspecies Chimerism with Mammalian Pluripotent Stem Cells Open

Jun Wu, Aida Platero-Luengo, Masahiro Sakurai, Atsushi Sugawara, M.A. Gil , et al. · 2017

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration Open

Keiichiro Suzuki, Yuji Tsunekawa, Reyna Hernández‐Benítez, Jun Wu, Jie Zhu , et al. · 2016

Three Cases of Oral Ulceration Caused by An Antirtheumatic Drug Open

Masako Yamashita, Yoshinori Jinbu, Emi Aizawa, Yoshiyuki Mori · 2016

メトトレキサート（MTX）は葉酸の構造類似体で，葉酸代謝酵素による活性型葉酸への変換を阻害し，細胞増殖を抑制する葉酸代謝拮抗剤に分類される抗癌剤である。低用量のMTXは疾患修飾性抗リウマチ薬（DMARD）として位置づけられており，関節リウマチ（RA）の治療で使用されている。今回われわれはMTX内服中に口腔粘膜に潰瘍を呈し，いずれも休薬により寛解した3症例を経験したので若干の文献的考察を加えて報告する。

An alternative pluripotent state confers interspecies chimaeric competency Open

Jun Wu, Daiji Okamura, Mo Li, Keiichiro Suzuki, Chongyuan Luo , et al. · 2015

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging Open

Weiqi Zhang, Jingyi Li, Keiichiro Suzuki, Jing Qu, Ping Wang , et al. · 2015

Heterochromatin in aging stem cells Analysis of human aging syndromes, such as Werner syndrome (WS), may lead to greater understanding of both premature and normal aging. Zhang et al. generated isogenic WS-specific human embryonic stem cel…

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