Emil Eik Nielsen
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View article: One-year CT evaluation of fusion in adult spinal deformity using supplemental anterior lumbar interbody fusion
One-year CT evaluation of fusion in adult spinal deformity using supplemental anterior lumbar interbody fusion Open
Purpose The purpose of this study was to report the one-year posterior fusion rate in patients with adult spinal deformity (ASD) undergoing posterior spinal fusion (PSF) with supplemental lumbar interbody fusion (LIF). Methods Patients wit…
View article: Methods for drug delivery and compatibility studies in an ex vivo mucus-covered Caco-2 cell monolayer model
Methods for drug delivery and compatibility studies in an ex vivo mucus-covered Caco-2 cell monolayer model Open
Oral drug delivery studies are increasingly done using the Caco-2 cell monolayer model overlaid with simple or complex in vitro mucus matrices as the model then becomes more robust towards otherwise cytotoxic biorelevant conditions. Howeve…
View article: OPTIHEART: determinants and prognostic importance of optimal medical treatment in patients with heart failure with reduced ejection fraction discharged from a heart failure clinic from 2018 to 2020
OPTIHEART: determinants and prognostic importance of optimal medical treatment in patients with heart failure with reduced ejection fraction discharged from a heart failure clinic from 2018 to 2020 Open
OMT was more frequently achieved in patients with male sex independently of age, DBP, and creatinine. Achieving OMT was associated with less 5-point MACE independently of female sex, younger age, never smoking and NYHA ≤ 2.
View article: A multidisciplinary, shared care clinic using personalized medicine and coordinated care in patients with concomitant type 2 diabetes and cardiovascular disease. Protocol and baseline characteristics
A multidisciplinary, shared care clinic using personalized medicine and coordinated care in patients with concomitant type 2 diabetes and cardiovascular disease. Protocol and baseline characteristics Open
To our knowledge, a similar study with a multidisciplinary, shared care, outpatient clinic treating people living with concomitant T2DM and CVD, has not been performed previously. This study will provide information about the feasibility a…
View article: Sex Differences in Atrial Fibrillation and Associated Complications in Hypertensive Patients with Left Ventricular Hypertrophy: The LIFE Study
Sex Differences in Atrial Fibrillation and Associated Complications in Hypertensive Patients with Left Ventricular Hypertrophy: The LIFE Study Open
BACKGROUND There is no consensus on whether biological differences account for the higher risk of stroke seen in females compared to males with atrial fibrillation (AF). METHODS Capitalizing on The Losartan Intervention for Endpoint study,…
View article: Drug interventions for prevention of COVID-19 progression to severe disease in outpatients: a systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
Drug interventions for prevention of COVID-19 progression to severe disease in outpatients: a systematic review with meta-analyses and trial sequential analyses (The LIVING Project) Open
Objectives To assess the effects of interventions authorised by the European Medicines Agency (EMA) or the US Food and Drug Administration (FDA) for prevention of COVID-19 progression to severe disease in outpatients. Setting Outpatient tr…
View article: Vaccines to prevent COVID-19: A living systematic review with Trial Sequential Analysis and network meta-analysis of randomized clinical trials
Vaccines to prevent COVID-19: A living systematic review with Trial Sequential Analysis and network meta-analysis of randomized clinical trials Open
Background COVID-19 is rapidly spreading causing extensive burdens across the world. Effective vaccines to prevent COVID-19 are urgently needed. Methods and findings Our objective was to assess the effectiveness and safety of COVID-19 vacc…
View article: Ivabradine added to usual care in patients with heart failure: a systematic review with meta-analysis and trial sequential analysis
Ivabradine added to usual care in patients with heart failure: a systematic review with meta-analysis and trial sequential analysis Open
Objectives To assess the beneficial and harmful effects of adding ivabradine to usual care in participants with heart failure. Design A systematic review with meta-analysis and trial sequential analysis. Eligibility criteria Randomised cli…
View article: Beta-blockers for heart failure
Beta-blockers for heart failure Open
This protocol for a Cochrane Review has been withdrawn. The editors of Cochrane Heart have concluded that the review's question is no longer of clinical pertinence.
View article: Drug-eluting stents versus bare-metal stents for non-acute ischaemic heart disease
Drug-eluting stents versus bare-metal stents for non-acute ischaemic heart disease Open
The editorial team of Cochrane Heart made the decision to withdraw this protocol for a Cochrane Review as the question is no longer pertinent to current clinical practice.
View article: Bicarbonate for acute acidosis
Bicarbonate for acute acidosis Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of adding bicarbonate to usual care in people with acute metabolic acidosis or respiratory acidosis.
View article: Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
Interventions for treatment of COVID-19: Second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project) Open
Background COVID-19 is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world. Effective treatments of COVID-19 are urgently needed. This is the second edition of a living systematic…
View article: Lenient rate control versus strict rate control for atrial fibrillation: a protocol for the Danish Atrial Fibrillation (DanAF) randomised clinical trial
Lenient rate control versus strict rate control for atrial fibrillation: a protocol for the Danish Atrial Fibrillation (DanAF) randomised clinical trial Open
Introduction Atrial fibrillation is the most common heart arrhythmia with a prevalence of approximately 2% in the western world. Atrial fibrillation is associated with an increased risk of death and morbidity. In many patients, a rate cont…
View article: A new tool to assess Clinical Diversity In Meta‐analyses (CDIM) of interventions
A new tool to assess Clinical Diversity In Meta‐analyses (CDIM) of interventions Open
CDIM is the first tool developed for assessing clinical diversity in meta-analyses of interventions. We found CDIM to be a reliable tool for assessing clinical diversity among trials in meta-analysis.
View article: Interventions for treatment of COVID-19: second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
Interventions for treatment of COVID-19: second edition of a living systematic review with meta-analyses and trial sequential analyses (The LIVING Project) Open
Background COVID-19 is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world. Effective treatments of COVID-19 are urgently needed. This is the second edition of a living systematic…
View article: Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project)
Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project) Open
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes corona virus disease 2019 (COVID-19) which has rapidly spread worldwide. Several human randomized clinical trials assessing potential vaccines are currently un…
View article: Beneficial and harmful effects of sacubitril/valsartan in patients with heart failure: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
Beneficial and harmful effects of sacubitril/valsartan in patients with heart failure: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis Open
Current guidelines recommend angiotensin receptor blocker neprilysin inhibitors (ARNI) (sacubitril/valsartan) as a replacement for angiotensin-converting-enzymeinhibitor (ACE-I) in heart failure with reduced ejection fraction (HFrEF) who r…
View article: Effects of adding ivabradine to usual care in patients with angina pectoris: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis
Effects of adding ivabradine to usual care in patients with angina pectoris: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis Open
Objective To determine the impact of ivabradine on outcomes important to patients with angina pectoris caused by coronary artery disease. Methods We conducted a systematic review. We included randomised clinical trials comparing ivabradine…
View article: Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project) Open
Our results show that dexamethasone and remdesivir might be beneficial for COVID-19 patients, but the certainty of the evidence was low to very low, so more trials are needed. We can exclude the possibility of hydroxychloroquine versus sta…
View article: Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project)
Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project) Open
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes corona virus disease 2019 (COVID-19) which has rapidly spread worldwide. Several human randomized clinical trials assessing potential vaccines are currently un…
View article: Non-acute percutaneous coronary intervention versus medical therapy in patients with ischaemic heart disease
Non-acute percutaneous coronary intervention versus medical therapy in patients with ischaemic heart disease Open
This protocol has been withdrawn as the author team is unable to progress to the final review stage.
View article: Beta-blockers for suspected or diagnosed acute myocardial infarction
Beta-blockers for suspected or diagnosed acute myocardial infarction Open
Our present review indicates that beta-blockers for suspected or diagnosed acute myocardial infarction probably reduce the short-term risk of a reinfarction and the long-term risk of all-cause mortality and cardiovascular mortality. Nevert…
View article: Coronary artery bypass surgery plus medical therapy versus medical therapy alone for ischaemic heart disease: a protocol for a systematic review with meta-analysis and trial sequential analysis
Coronary artery bypass surgery plus medical therapy versus medical therapy alone for ischaemic heart disease: a protocol for a systematic review with meta-analysis and trial sequential analysis Open
Background Despite increasing survival, cardiovascular disease remains the primary cause of death worldwide with an estimated 7.4 million annual deaths. The main symptom of ischaemic heart disease is chest pain (angina pectoris) most often…