Emil Moiş
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View article: Differential Metabolic Dysregulations in Hepatocellular Carcinoma and Cirrhosis: Insights into Lipidomic Signatures
Differential Metabolic Dysregulations in Hepatocellular Carcinoma and Cirrhosis: Insights into Lipidomic Signatures Open
Hepatocellular carcinoma (HCC), the most common primary liver malignancy, usually develops in patients with cirrhosis, yet the metabolic mechanisms that distinguish the two conditions remain poorly understood. This study aimed to explore m…
View article: A Systematic Review and Meta-Analysis of Preoperative Biliary Drainage Methods in Periampullary Tumors
A Systematic Review and Meta-Analysis of Preoperative Biliary Drainage Methods in Periampullary Tumors Open
Background: Pancreatic and hepatobiliary tumors continue to rank among the deadliest cancers worldwide. Due to a low response rate to treatment, these tumors continue to have a high death rate, a poor prognosis and survival rate, and an ov…
View article: Biliary Drainage for the Preoperative Management of Periampullary Neoplasms: A Retrospective Cohort Study
Biliary Drainage for the Preoperative Management of Periampullary Neoplasms: A Retrospective Cohort Study Open
Background and Objectives: Preoperative biliary drainage (PBD) in patients with periampullary neoplasms remains a debated topic, with various techniques available and conflicting evidence regarding their impact on postoperative outcomes. T…
View article: Influence of SARS-CoV2 Pandemic on Colorectal Cancer Diagnosis, Presentation, and Surgical Management in a Tertiary Center: A Retrospective Study
Influence of SARS-CoV2 Pandemic on Colorectal Cancer Diagnosis, Presentation, and Surgical Management in a Tertiary Center: A Retrospective Study Open
Background: Oncological surgery during the COVID-19 pandemic was performed only in carefully selected cases, due to variation in the allocation of resources. The purpose of this study was to highlight the impact of the pandemic lockdown on…
View article: Comprehensive Overview of Molecular, Imaging, and Therapeutic Challenges in Rectal Mucinous Adenocarcinoma
Comprehensive Overview of Molecular, Imaging, and Therapeutic Challenges in Rectal Mucinous Adenocarcinoma Open
Rectal cancer is one of the most frequent malignancies worldwide. The most common histological type is adenocarcinoma, followed by mucinous adenocarcinoma. The outcome is less favorable for the mucinous type, yet the treatment course is th…
View article: A 3D-Printed, High-Fidelity Pelvis Training Model: Cookbook Instructions and First Experience
A 3D-Printed, High-Fidelity Pelvis Training Model: Cookbook Instructions and First Experience Open
Background: Since laparoscopic surgery became the gold standard for colorectal procedures, specific skills are required to achieve good outcomes. The best way to acquire basic and advanced skills and reach the learning curve plateau is by …
View article: On the Control and Validation of the PARA-SILSROB Surgical Parallel Robot
On the Control and Validation of the PARA-SILSROB Surgical Parallel Robot Open
This paper presents the development of the hardware and software architecture of a sixdegrees of freedom (DOF) parallel robot (PARA-SILSROB) by illustrating all the stages undertaken to achieve the experimental model of the robot. Based on…
View article: Liver Phantoms Cast in 3D-Printed Mold for Image-Guided Procedures
Liver Phantoms Cast in 3D-Printed Mold for Image-Guided Procedures Open
Introduction: Image-guided invasive procedures on the liver require a steep learning curve to acquire the necessary skills. The best and safest way to achieve these skills is through hands-on courses that include simulations and phantoms o…
View article: Gelatin-Based Liver Phantoms for Training Purposes: A Cookbook Approach
Gelatin-Based Liver Phantoms for Training Purposes: A Cookbook Approach Open
Background: Patients with liver pathology benefit from image-guided interventions. Training for interventional procedures is recommended to be performed on liver phantoms until a basic proficiency is reached. In the last 40 years, several …
View article: Prognostic Indicators of Overall Survival in Hepatocellular Carcinoma Patients Undergoing Liver Resection
Prognostic Indicators of Overall Survival in Hepatocellular Carcinoma Patients Undergoing Liver Resection Open
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and the third contributor to malignancy-related deaths worldwide. The hepatic venous pressure gradient (HVPG), transient elastography-liver stiffness measuremen…
View article: Impact on Long-term Survival of a Standardized Histopathological Protocol on the R1 Incidence in Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma
Impact on Long-term Survival of a Standardized Histopathological Protocol on the R1 Incidence in Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma Open
Background: Pancreatic Ductal Adenocarcinoma (PDAC) is a pathology with a very poor prognostic, the only curative treatment option being surgery, in association with chemotherapy. This study aims to assess the influence that the use of a s…
View article: Perineal Hernia Mesh Repair Using Only the Perineal Approach: How We Do It
Perineal Hernia Mesh Repair Using Only the Perineal Approach: How We Do It Open
Perineal hernia is a rare complication of rectal surgery. Different types of surgical approach have been described, but none of them have proven their superiority. Although there are many methods of closing the defect, we selected two case…
View article: Inflammatory Ratios as Survival Prognostic Factors in Resectable Gastric Adenocarcinoma
Inflammatory Ratios as Survival Prognostic Factors in Resectable Gastric Adenocarcinoma Open
Background: The purpose of the study was to assess the relationship between inflammatory biomarkers (NLR—neutrophil-to-lymphocyte ratio, PLR—platelet-to-lymphocyte ratio, LMR—lymphocyte-to-monocyte ratio, SII—systemic immune-inflammation i…
View article: Surgical management of hydatid cyst disease of the liver: An improvement from our previous experience?
Surgical management of hydatid cyst disease of the liver: An improvement from our previous experience? Open
Laparoscopic surgery still plays an important role in the treatment of hydatid disease of the liver, with an increase in its usage over the course of years that has shown benefits regarding the postoperative recovery with a decreased rate …
View article: Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study
Chitotriosidase and Neopterin as Two Novel Potential Biomarkers for Advanced Stage and Survival Prediction in Gastric Cancer—A Pilot Study Open
Gastric cancer is the fifth type of neoplasia most frequently diagnosed and the fourth cause of death among other cancers. Prevalence is around two times higher for males than females. Chitotriosidase and neopterin are two molecular biomar…
View article: Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study
Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study Open
Gallstones are a common surgical pathology. Laparoscopic cholecystectomy represents the elective treatment. Complicated cases can increase the rate of conversion, the duration, and the difficulty of the intervention, along with the hospita…
View article: Klatskin Tumor: A Survival Analysis According to Tumor Characteristics and Inflammatory Ratios
Klatskin Tumor: A Survival Analysis According to Tumor Characteristics and Inflammatory Ratios Open
Background and Objectives: The aim was to evaluate the association of inflammatory biomarkers with resectability and overall survival in hilar cholangiocarcinoma. Materials and Methods: We conducted a retrospective cohort study over 72 con…
View article: Inflammatory Ratios as Predictors for Tumor Invasiveness, Metastasis, Resectability and Early Postoperative Evolution in Gastric Cancer
Inflammatory Ratios as Predictors for Tumor Invasiveness, Metastasis, Resectability and Early Postoperative Evolution in Gastric Cancer Open
Our study aimed to evaluate the baseline neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) in relation to invasion, metastasis, and re…
View article: Trends in Minimally Invasive Approaches for Liver Resections–A Systematic Review
Trends in Minimally Invasive Approaches for Liver Resections–A Systematic Review Open
Background: SILS (single incision laparoscopic surgery) and NOTES (natural orifice transluminal endoscopic surgery) are considered breakthroughs in minimally invasive surgery, the first consisting in the surgeon working via a single entran…
View article: Nanotechnology in the Diagnostic and Therapy of Hepatocellular Carcinoma
Nanotechnology in the Diagnostic and Therapy of Hepatocellular Carcinoma Open
Hepatocellular carcinoma is the most common liver malignancy and is among the top five most common cancers. Despite the progress of surgery and chemotherapy, the results are often disappointing, in part due to chemoresistance. This type of…
View article: Risk Assessment-Oriented Design of a Needle Insertion Robotic System for Non-Resectable Liver Tumors
Risk Assessment-Oriented Design of a Needle Insertion Robotic System for Non-Resectable Liver Tumors Open
Medical robotics is a highly challenging and rewarding field of research, especially in the development of minimally invasive solutions for the treatment of the worldwide leading cause of death, cancer. The aim of the paper is to provide a…
View article: Duodenopancreatectomy for PDAC Associated with MALS: A Case Report
Duodenopancreatectomy for PDAC Associated with MALS: A Case Report Open
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive form of pancreatic malignancy which occurs in over 90% of such cases. Pancreaticoduodenectomy (PD) is used with a curative purpose for localized PDAC. Case presentation…
View article: Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma: When and how?
Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma: When and how? Open
Hilar cholangiocarcinoma (hCCA) is a primary liver tumor associated with a dim prognosis. The role of preoperative and palliative biliary drainage has long been debated. The most common techniques are endoscopic retrograde cholangiopancrea…
View article: The phytochemical constituents and therapeutic uses of genus Aloe: A review
The phytochemical constituents and therapeutic uses of genus Aloe: A review Open
Aloe, the largest genus in the Asphodelaceae family, comprises 548 species, with A. vera, A. arborescens and A. ferox being among the most widely studied species. Aloe species originated in arid climates and cover various habitats, from se…
View article: Lipidomic Signatures for Colorectal Cancer Diagnosis and Progression Using UPLC-QTOF-ESI+MS
Lipidomic Signatures for Colorectal Cancer Diagnosis and Progression Using UPLC-QTOF-ESI+MS Open
Metabolomics coupled with bioinformatics may identify relevant biomolecules such as putative biomarkers of specific metabolic pathways related to colorectal diagnosis, classification and prognosis. This study performed an integrated metabo…
View article: Stapled Hemorrhoidopexy: Technique and Long Term Results
Stapled Hemorrhoidopexy: Technique and Long Term Results Open
Background: Stapled hemorrhoidopexy (Longo operation) is a infrequent technique in our area. A different concept from hemorrhoidectomy, a proportionally important raise in cost and a special training may have contributed to it. We report o…
View article: Lipidomics: advanced analytical technology to identify biomarkers of colorectal cancer
Lipidomics: advanced analytical technology to identify biomarkers of colorectal cancer Open
Lipidomics is an advanced analytical technology applying techniques like Gas-or Liquid Chromatography coupled with Mass Spectrometry or Magnetic Resonance Spectrometry to find the lipid biomarkers in tissues, blood or urine.This review sel…
View article: Malnutrition and non-compliance to nutritional recommendations in patients with cirrhosis are associated with a lower survival
Malnutrition and non-compliance to nutritional recommendations in patients with cirrhosis are associated with a lower survival Open
The prevalence of malnutrition is high among patients with advanced cirrhosis and might be related in part to a low adherence to nutritional recommendations, especially with regards to protein intake.
View article: Metabolomic profile of colorectal cancer patients and its clinical implications
Metabolomic profile of colorectal cancer patients and its clinical implications Open
Background: Colorectal Cancer (CRC) is a great public health issue and the outcomes of treatment depends on early diagnosis. Metabolomics may provide biomarkers for early diagnosis, staging, prognosis and follow-up. Methods: The authors se…
View article: Microwave ablation in the treatment of liver tumors. A better tool or simply more power?
Microwave ablation in the treatment of liver tumors. A better tool or simply more power? Open
It has been a long time since tumor ablation was first tested in patients with liver cancer, especially hepatocellular carcinoma. Since than it has become a first line treatment modality for hepatocellular carcinoma. Over the years, the in…