Emilie Alirol
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View article: Effect of food on the pharmacokinetics of zoliflodacin granules for oral suspension: Phase I <scp>open‐label</scp> randomized cross‐over study in healthy subjects
Effect of food on the pharmacokinetics of zoliflodacin granules for oral suspension: Phase I <span>open‐label</span> randomized cross‐over study in healthy subjects Open
Gonorrhea is a sexually transmitted infection for which antibiotic treatment options have declined due to increasing antibiotic resistance. Zoliflodacin, an investigational oral spiropyrimidinetrione antibiotic with activity against Neisse…
View article: Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model
Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model Open
Antimicrobial resistance in Neisseria gonorrhoeae is threatening the treatment and control of gonorrhea globally, and new treatment options are imperative. Utilizing our dynamic in vitro hollow fiber infection model (HFIM), we examined the…
View article: Developing target product profiles for Neisseria gonorrhoeae diagnostics in the context of antimicrobial resistance: An expert consensus
Developing target product profiles for Neisseria gonorrhoeae diagnostics in the context of antimicrobial resistance: An expert consensus Open
Following the working group revisions, TPPs were posted online for public feedback for two months, and are now finalized. The final TPPs are currently guiding the development of new diagnostics that meet the defined characteristics to reac…
View article: Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea—challenges and opportunities
Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea—challenges and opportunities Open
View article: High <i>In Vitro</i> Susceptibility to the First-in-Class Spiropyrimidinetrione Zoliflodacin among Consecutive Clinical Neisseria gonorrhoeae Isolates from Thailand and South Africa
High <i>In Vitro</i> Susceptibility to the First-in-Class Spiropyrimidinetrione Zoliflodacin among Consecutive Clinical Neisseria gonorrhoeae Isolates from Thailand and South Africa Open
We evaluated the in vitro susceptibility to the first-in-class spiropyrimidinetrione zoliflodacin among recent consecutive clinical Neisseria gonorrhoeae isolates cultured in Thailand ( n = 99) (in 2018) and South Africa ( n = 100) (in 201…
View article: In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae
In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae Open
Objectives Resistance in Neisseria gonorrhoeae to all gonorrhoea therapeutic antimicrobials has emerged. Novel therapeutic antimicrobials are imperative and the first-in-class spiropyrimidinetrione zoliflodacin appears promising. Zolifloda…
View article: O06.2 <i>In vitro</i>combination testing and selection of resistance to zoliflodacin combined with six antimicrobials for<i>N. gonorrhoeae</i>
O06.2 <i>In vitro</i>combination testing and selection of resistance to zoliflodacin combined with six antimicrobials for<i>N. gonorrhoeae</i> Open
Background Resistance in Neisseria gonorrhoeae to all therapeutic antimicrobials for gonorrhoea has emerged. Novel antimicrobials for treatment are imperative and the first-in-class spiropyrimidinetrione zoliflodacin appears promisi…
View article: Acute Severe Anaphylaxis in Nepali Patients with Neurotoxic Snakebite Envenoming Treated with the VINS Polyvalent Antivenom
Acute Severe Anaphylaxis in Nepali Patients with Neurotoxic Snakebite Envenoming Treated with the VINS Polyvalent Antivenom Open
Diagnosing and treating acute severe and recurrent antivenom-related anaphylaxis (ARA) is challenging and reported experience is limited. Herein, we describe our experience of severe ARA in patients with neurotoxic snakebite envenoming in …
View article: Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines
Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines Open
Emilie Alirol and colleagues discuss the development of new treatments for gonorrhea.
View article: Erratum to: Ethics review of studies during public health emergencies - the experience of the WHO ethics review committee during the Ebola virus disease epidemic
Erratum to: Ethics review of studies during public health emergencies - the experience of the WHO ethics review committee during the Ebola virus disease epidemic Open
View article: Ethics review of studies during public health emergencies - the experience of the WHO ethics review committee during the Ebola virus disease epidemic
Ethics review of studies during public health emergencies - the experience of the WHO ethics review committee during the Ebola virus disease epidemic Open
To accelerate study approval in future public health emergencies, we recommend: (1) internally consistent and complete submissions with information documents in language participants are likely to understand, (2) close collaboration betwee…
View article: Dose of antivenom for the treatment of snakebite with neurotoxic envenoming: Evidence from a randomised controlled trial in Nepal
Dose of antivenom for the treatment of snakebite with neurotoxic envenoming: Evidence from a randomised controlled trial in Nepal Open
The study was registered on clinicaltrials.gov (NCT01284855) (GJ 5/1).
View article: Safety and Effectiveness of Sodium Stibogluconate and Paromomycin Combination for the Treatment of Visceral Leishmaniasis in Eastern Africa: Results from a Pharmacovigilance Programme
Safety and Effectiveness of Sodium Stibogluconate and Paromomycin Combination for the Treatment of Visceral Leishmaniasis in Eastern Africa: Results from a Pharmacovigilance Programme Open
View article: The Art of Writing and Implementing Standard Operating Procedures (SOPs) for Laboratories in Low-Resource Settings: Review of Guidelines and Best Practices
The Art of Writing and Implementing Standard Operating Procedures (SOPs) for Laboratories in Low-Resource Settings: Review of Guidelines and Best Practices Open
The Art of Writing and Implementing Standard Operating Procedures (SOPs) for Laboratories in Low-Resource Settings: Review of Guidelines and Best Practices
View article: Experiences and Lessons from a Multicountry NIDIAG Study on Persistent Digestive Disorders in the Tropics
Experiences and Lessons from a Multicountry NIDIAG Study on Persistent Digestive Disorders in the Tropics Open
Experiences and Lessons from a Multicountry NIDIAG Study on Persistent Digestive Disorders in the Tropics
View article: Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study
Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study Open
In resource-limited settings, the scarcity of skilled personnel and adequate laboratory facilities makes the differential diagnosis of fevers complex [1-5]. Febrile illnesses are diagnosed clinically in most rural centers, and both Rapid D…
View article: Clinical Research in Neglected Tropical Diseases: The Challenge of Implementing Good Clinical (Laboratory) Practices
Clinical Research in Neglected Tropical Diseases: The Challenge of Implementing Good Clinical (Laboratory) Practices Open
Pharmaceutical research and development (R&D) historically neglected the infectious diseases that mainly or exclusively affect poor communities in low- and middle-income countries (LMICs) [1]. Recently, collaborative clinical research addr…
View article: Fatal neurotoxic envenomation following the bite of a greater black krait (Bungarus niger) in Nepal: a case report
Fatal neurotoxic envenomation following the bite of a greater black krait (Bungarus niger) in Nepal: a case report Open
View article: Use of Molecular Diagnostic Tools for the Identification of Species Responsible for Snakebite in Nepal: A Pilot Study
Use of Molecular Diagnostic Tools for the Identification of Species Responsible for Snakebite in Nepal: A Pilot Study Open
Snakebite is an important medical emergency in rural Nepal. Correct identification of the biting species is crucial for clinicians to choose appropriate treatment and anticipate complications. This is particularly important for neurotoxic …
View article: Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults
Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults Open
Drug-resistant tuberculosis (DR-TB) is a growing public health problem, and for the first time in decades, new drugs for the treatment of this disease have been developed. These new drugs have prompted strengthened efforts in DR-TB clinica…
View article: Erratum to: Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): a multi-country, prospective, non-experimental case–control study
Erratum to: Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): a multi-country, prospective, non-experimental case–control study Open
Unfortunately the original article [1] contained a typo in the title. Instead of “Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): a multi-country, pros…
View article: Antivenoms for Snakebite Envenoming: What Is in the Research Pipeline?
Antivenoms for Snakebite Envenoming: What Is in the Research Pipeline? Open
Of the 24 neglected tropical diseases (NTDs) and conditions listed by WHO, snakebite is among the top killers [1]. Tens of thousands of people die each year as a result of snakebite envenoming, with close to 50,000 deaths in India alone [2…
View article: Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): a multi-country, prospective, non-experimental case–control study
Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain ≥14 days): a multi-country, prospective, non-experimental case–control study Open
View article: Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain >= 14 days): a multi-country, prospective, non-experimental case-control study (vol 15, 338, 2015)
Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain >= 14 days): a multi-country, prospective, non-experimental case-control study (vol 15, 338, 2015) Open