Explanipedia

Adenovirus phagocytosis by neutrophils triggers a pro-inflammatory response Open

Salomé Laurans, Soizic Huerre, Olivier Dellis, Céline Férard, Hadrien Jalaber , et al. · 2025

Adenoviruses are common pathogens that have been engineered and used for medical purposes. Their recognition by innate immune cells such as macrophages and dendritic cells has been widely studied, but very little information is available o…

Safe and Sustainable by Design MOF Beads for Selective Entrapment and Recovery of Rare Earth Elements Open

Prathmesh Bhadane, Pankti Dhumal, Émilie Brun, Andrew J. Britton, Iseult Lynch , et al. · 2025

We report the development of CA-BNMG-1 composite beads-cellulose acetate macrobeads embedded with nanosized copper imidazolate MOFs (BNMG-1) -engineered via nonsolvent-induced phase separation for the selective recovery of rare earth eleme…

CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials Open

Dimitrios Zouraris, Angelos Mavrogiorgis, Andreas Tsoumanis, Laura Aliisa Saarimäki, Giusy del Giudice , et al. · 2024

The CompSafeNano project, a Research and Innovation Staff Exchange (RISE) project funded under the European Union's Horizon 2020 program, aims to advance the safety and innovation potential of nanomaterials (NMs) by integrating cutting-edg…

Both experimental and molecular dynamics approaches highlight the central role of interfacial water for radical production by irradiated gold nanoparticles Open

Émilie Brun, Rika Tandiana, Manon Gilles, Yannis Cheref, Nguyen‐Thi Van‐Oanh , et al. · 2024

Nanoparticles devoted to improve radiotherapy treatments are an efficient tool if they can induce the formation of deleterious species in the tumor. Their interaction with radiation is responsible for radical production but in spite of the…

Milled Nanodiamonds Overproduce Solvated Electrons while Scavenging Hydroxyl Radicals under Gamma Irradiation Open

Florent Ducrozet, Émilie Brun, Hugues A. Girard, Jean‐Charles Arnault, Cécile Sicard‐Roselli · 2023

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Wfs1E864K knock-in mice illuminate the fundamental role of Wfs1 in endocochlear potential production Open

Élodie M. Richard, Émilie Brun, Julia Korchagina, Lucie Crouzier, Corentin Affortit , et al. · 2023

Wolfram syndrome (WS) is a rare neurodegenerative disorder encompassing diabetes mellitus , diabetes insipidus , optic atrophy, hearing loss (HL) as well as neurological disorders. None of the animal models of the pathology are presenting …

Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation Open

E. Guillet, Émilie Brun, Céline Férard, Kévin Hardonnière, Myriam Nabhan , et al. · 2023

Unintentional formation of nitrate and nitrite ions during nanodiamonds sonication: A source of radical and electron scavengers Open

Florent Ducrozet, Hugues A. Girard, Teodor Jianu, S. Peulon, Émilie Brun , et al. · 2023

Wfs1E864K knock-in mice illuminate the fundamental role of Wfs1 in endocochlear potential production Open

Élodie M. Richard, Émilie Brun, Julia Korchagina, Lucie Crouzier, Corentin Affortit , et al. · 2023

Wolfram syndrome (WS) is a rare neurodegenerative disease encompassing diabetes mellitus , diabetes insipidus , optic atrophy, hearing loss (HL) and neurological disorders. None of the animal models of the pathology are presenting with an …

Plus-value du collectif en conception de ressources numériques ouvertes Open

Valérie Camel, Marie‐Noëlle Maillard, Jonathan Piard, Cécile Sicard‐Roselli, Émilie Brun , et al. · 2022

International audience

Corrigendum to: Synthetic Amorphous Silica Nanoparticles Promote Human Dendritic Cell Maturation and CD4+ T-Lymphocyte Activation Open

Alexia Feray, E. Guillet, Natacha Szely, Marie Hullo, François‐Xavier Legrand , et al. · 2021

New Insights into the Reactivity of Detonation Nanodiamonds during the First Stages of Graphitization Open

Florent Ducrozet, Hugues A. Girard, Jocelyne Leroy, Éric Larquet, Ileana Florea , et al. · 2021

The present study aims to compare the early stages of graphitization of the same DND source for two annealing atmospheres (primary vacuum, argon at atmospheric pressure) in an identical set-up. DND samples are finely characterized by a com…

Synthetic Amorphous Silica Nanoparticles Promote Human Dendritic Cell Maturation and CD4+ T-Lymphocyte Activation Open

Alexia Feray, E. Guillet, Natacha Szely, Marie Hullo, François‐Xavier Legrand , et al. · 2021

Innate immune cells such as dendritic cells (DCs) sense and engulf nanomaterials potentially leading to an adverse immune response. Indeed, as described for combustion-derived particles, nanomaterials could be sensed as danger signals, ena…

Probing the structural properties of the water solvation shell around gold nanoparticles: A computational study Open

Rika Tandiana, Émilie Brun, Cécile Sicard‐Roselli, Dominik Domin, Nguyen‐Thi Van‐Oanh , et al. · 2021

While subjected to radiation, gold nanoparticles (GNPs) have been shown to enhance the production of radicals when added to aqueous solutions. It has been proposed that the arrangement of water solvation layers near the water–gold interfac…

CHIMACTIV pour se former à l’analyse chimique Open

Valérie Camel, Marie‐Noëlle Maillard, Mathieu Cladière, Gérôme Fitoussi, Jonathan Piard , et al. · 2020

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CHIMACTIV: An Open-Access Website for Student-Centered Learning in Analytical Chemistry Open

Valérie Camel, Marie‐Noëlle Maillard, Jonathan Piard, Cécile Dumas, Mathieu Cladière , et al. · 2020

International audience

How to Address the Adjuvant Effects of Nanoparticles on the Immune System Open

Alexia Feray, Natacha Szely, E. Guillet, Marie Hullo, François‐Xavier Legrand , et al. · 2020

As the nanotechnology market expands and the prevalence of allergic diseases keeps increasing, the knowledge gap on the capacity of nanomaterials to cause or exacerbate allergic outcomes needs more than ever to be filled. Engineered nanopa…

Hydrogen plasma treated nanodiamonds lead to an overproduction of hydroxyl radicals and solvated electrons in solution under ionizing radiation Open

Émilie Brun, Hugues A. Girard, Jean‐Charles Arnault, Michel Mermoux, Cécile Sicard‐Roselli · 2020

CHIMACTIV, un site pour se former à l’analyse chimique Open

Valérie Camel, Marie‐Noëlle Maillard, Mathieu Cladière, Gérôme Fitoussi, Jonathan Piard , et al. · 2020

International audience

Quality control of gold nanoparticles as pharmaceutical ingredients Open

Arnaud Pallotta, Ariane Boudier, Benjamin Creusot, Émilie Brun, Cécile Sicard‐Roselli , et al. · 2019

La construction du site pédagogique numérique CHIMACTIV : analyse d’une coopération réussie entre enseignants Open

Valérie Camel, Jonathan Piard, Gérôme Fitoussi, Mathieu Cladière, Cécile Dumas , et al. · 2019

International audience

Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O2 and radiosensitization by nanoparticles Open

Gérard Baldacchino, Émilie Brun, Ibtihel Denden, Sarah Bouhadoun, R. Roux , et al. · 2019

Metallic bismuth nanoparticles: Towards a robust, productive and ultrasound assisted synthesis from batch to flow-continuous chemistry Open

Catherine Gomez, Gauthier Hallot, Alexandra Pastor, Sophie Laurent, Émilie Brun , et al. · 2019

Gold Nanoparticle Uptake in Tumor Cells: Quantification and Size Distribution by sp-ICPMS Open

Johanna Noireaux, Romain Grall, Marie Hullo, Sylvie Chevillard, Caroline Oster , et al. · 2019

Gold nanoparticles (AuNPs) are increasingly studied for cancer treatment purposes, as they can potentially improve both control and efficiency of the treatment. Intensive research is conducted in vitro on rodent and human cell lines to obj…

N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model Open

Aurore Marie, Johann Meunier, Émilie Brun, Susanna Malmström, Véronique Baudoux , et al. · 2018

Age-related hearing loss (ARHL) is the most common sensory disorder in the elderly population. SAMP8 mouse model presents accelerated senescence and has been identified as a model of gerontological research. SAMP8 displays a progressive ag…

Brain Inflammation, Blood Brain Barrier dysfunction and Neuronal Synaptophysin Decrease after Inhalation Exposure to Titanium Dioxide Nano-aerosol in Aging Rats Open

Clémence Disdier, Monique Chalansonnet, F. Gagnaire, Laurent Gaté, Frédéric Cosnier , et al. · 2017

Hydroxyl radical production induced by plasma hydrogenated nanodiamonds under X-ray irradiation Open

Magdalena Kurzyp, Hugues A. Girard, Yannis Cheref, Émilie Brun, Cécile Sicard‐Roselli , et al. · 2016

For the first time, overproduction of hydroxyl radicals (HO˙) induced by plasma hydrogenated detonation nanodiamonds (H-NDs) under X-ray irradiation is reported.

Mineralization of TiO2 nanoparticles for the determination of titanium in rat tissues Open

Jérôme Devoy, Émilie Brun, Anne Cosnefroy, Clémence Disdier, Mathieu Melczer , et al. · 2016

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Loss of function of Ywhah in mice induces deafness and cochlear outer hair cells' degeneration Open

L Buret, Guy Rebillard, Émilie Brun, Cécile Angebault, Marie O. Péquignot , et al. · 2016

Expression of the Fatp family in the retina. Open

Karim Chekroud, Laurent Guillou, Grégoire Stéphane, Ducharme Gilles, Émilie Brun , et al. · 2015

A. Expression of the Fatp family in Fatp1^+/+ neuroretina (NR) and retinal pigment epithelium (RPE). Only Fatp1 and Fatp4 were expressed in both tissues. Fatp4 predominated in the NR and Fatp…

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