Emilie Dalbram
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View article: Repeated disuse atrophy imprints a molecular memory in skeletal muscle: transcriptional resilience in young adults and susceptibility in aged muscle
Repeated disuse atrophy imprints a molecular memory in skeletal muscle: transcriptional resilience in young adults and susceptibility in aged muscle Open
Disuse-induced muscle atrophy is common after illness, injury, or falls and becomes increasingly frequent with ageing. Whether skeletal muscle retains a “memory” of repeated disuse remains unknown. We investigated repeated lower-limb immob…
View article: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging Open
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numerous regulatory proteins. Dysregulations of NAD metabolism are widely regarded as detriment…
View article: Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia
Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia Open
View article: Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments
Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments Open
View article: Seasonal light hours modulate peripheral clocks and energy metabolism in mice
Seasonal light hours modulate peripheral clocks and energy metabolism in mice Open
Except for latitudes close to the equator, seasonal variation in light hours can change dramatically between summer and winter. Yet investigations into the interplay between energy metabolism and circadian rhythms typically use a 12 h ligh…
View article: NAMPT-dependent NAD <sup>+</sup> biosynthesis controls circadian metabolism in a tissue-specific manner
NAMPT-dependent NAD <sup>+</sup> biosynthesis controls circadian metabolism in a tissue-specific manner Open
Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating input from the hypothalamic master clock and intracellular metabolic signals. One such key metabolic signal is the cellular concentration of NAD +…
View article: A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals
A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals Open
BACKGROUNDDuring aging, there is a functional decline in the pool of muscle stem cells (MuSCs) that influences the functional and regenerative capacity of skeletal muscle. Preclinical evidence has suggested that nicotinamide riboside (NR) …
View article: Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes Open
Dysregulation of skeletal muscle metabolism influences whole body insulin sensitivity and glucose homeostasis. We hypothesized that type 2 diabetes-associated alterations in the plasma metabolome directly contribute to skeletal muscle immu…
View article: Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes Open
Dysregulation of skeletal muscle metabolism influences whole body insulin sensitivity and glucose homeostasis. We hypothesized that type 2 diabetes-associated alterations in the plasma metabolome directly contribute to skeletal muscle immu…
View article: Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes Open
Dysregulation of skeletal muscle metabolism influences whole-body insulin sensitivity and glucose homeostasis. We hypothesized that type 2 diabetes–associated alterations in the plasma metabolome directly contribute to skeletal muscle immu…
View article: A randomized placebo-controlled clinical trial of Nicotinamide Riboside and Pterostilbene supplementation in experimental muscle injury in elderly subjects
A randomized placebo-controlled clinical trial of Nicotinamide Riboside and Pterostilbene supplementation in experimental muscle injury in elderly subjects Open
Background Maintenance and regeneration of functional skeletal muscle are dependent on a sufficient pool of muscle stem cells (MuSCs). During ageing there is a functional decline in this cellular pool which influences the regenerative capa…
View article: Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity Open
View article: TableS2 - Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor
TableS2 - Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor Open
Skeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Using mass spectrometry (MS)-based proteomics, we characterized the secretome and identified thymosin…
View article: TableS1 - Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor
TableS1 - Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor Open
TableS1. Conditioned media proteome (secretome) from EPS-stimulated C2C12 myotubes and their controls.
View article: TableS4. 1D enrichment for GOBP and GOCC of log-fold change (EPS vs Ctrl) in the secretome.
TableS4. 1D enrichment for GOBP and GOCC of log-fold change (EPS vs Ctrl) in the secretome. Open
Discovery of Thymosin Beta-4 as a Human Exerkine and Growth FactorSkeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Using mass spectrometry (MS)…
View article: Supplementary Tables - Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor
Supplementary Tables - Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor Open
Skeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Using mass spectrometry (MS)-based proteomics, we characterized the secretome and identified thymosin…
View article: TableS1. Conditioned media proteome (secretome) from EPS-stimulated C2C12 myotubes and their controls.
TableS1. Conditioned media proteome (secretome) from EPS-stimulated C2C12 myotubes and their controls. Open
Discovery of Thymosin Beta-4 as a Human Exerkine and Growth FactorSkeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Using mass spectrometry (MS)…
View article: TableS4 - Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor
TableS4 - Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor Open
Skeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Using mass spectrometry (MS)-based proteomics, we characterized the secretome and identified thymosin…
View article: TableS3 Conditioned media proteome (secretome) from EPS-stimulated C2C12 myotubes and their controls prior to imputation.
TableS3 Conditioned media proteome (secretome) from EPS-stimulated C2C12 myotubes and their controls prior to imputation. Open
Discovery of Thymosin Beta-4 as a Human Exerkine and Growth FactorSkeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Using mass spectrometry (MS)…
View article: TableS3 - Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor
TableS3 - Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor Open
Skeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Using mass spectrometry (MS)-based proteomics, we characterized the secretome and identified thymosin…
View article: TableS2. Cell proteome from EPS-stimulated C2C12 myotubes and their controls.
TableS2. Cell proteome from EPS-stimulated C2C12 myotubes and their controls. Open
Discovery of Thymosin Beta-4 as a Human Exerkine and Growth FactorSkeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in inter-organ crosstalk. Using mass spectrometry (MS)…
View article: Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise Open
View article: Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action
Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action Open
Metabolic dysfunction and Type 2 diabetes are associated with perturbed circadian rhythms. However, exercise appears to ameliorate circadian disturbances, as it can phase-shift or reset the internal clock system. Evidence is emerging that …
View article: Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise
Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise Open
Reactive oxygen species (ROS) act as intracellular compartmentalized second messengers mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested to stimulate glucose transporter 4 (GLUT4)-dependent glucose t…
View article: Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status
Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status Open
Circadian rhythms can be perturbed by shift work, travel across time zones, many occupational tasks, or genetic mutations. Perturbed circadian rhythms are associated with the increasing problem of obesity, metabolic dysfunction, and insuli…