Emilio Mateev
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View article: A novel UHPLC method for quantitative analysis of five anthraquinone derivatives in Asphodeline plant extracts
A novel UHPLC method for quantitative analysis of five anthraquinone derivatives in Asphodeline plant extracts Open
A reverse-phase ultra-high-performance liquid chromatography (UHPLC) method was established in this study for the simultaneous determination of five anthraquinones in extracts of Asphodeline species. A gradient program was used for chromat…
View article: Oxidative stress as a key factor in the pathophysiology of neurodegenerative diseases: molecular mechanisms and protection pathways – Review
Oxidative stress as a key factor in the pathophysiology of neurodegenerative diseases: molecular mechanisms and protection pathways – Review Open
Aging is the main risk factor in neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). It has been widely demonstrated that oxidative stress c…
View article: Integrated experimental and computational study of novel pyrrole derivatives: Microwave-assisted synthesis, enzyme inhibition, antioxidant properties, and neurotoxicity evaluation
Integrated experimental and computational study of novel pyrrole derivatives: Microwave-assisted synthesis, enzyme inhibition, antioxidant properties, and neurotoxicity evaluation Open
View article: Design, Synthesis, and Evaluation of Pyrrole-Based Selective MAO-B Inhibitors with Additional AChE Inhibitory and Neuroprotective Properties Identified via Virtual Screening
Design, Synthesis, and Evaluation of Pyrrole-Based Selective MAO-B Inhibitors with Additional AChE Inhibitory and Neuroprotective Properties Identified via Virtual Screening Open
Background: Virtual screening is a widely adopted technique for the discovery of novel pharmacologically active compounds; however, the risk of identifying false positive hits remains a major challenge. Aim: The aim of this study was to pe…
View article: Phenolic Derivatives of Astragalus aitosensis with Selective MAO-B Inhibition and Mitochondrial Protection
Phenolic Derivatives of Astragalus aitosensis with Selective MAO-B Inhibition and Mitochondrial Protection Open
Astragalus aitosensis, also known as Astracantha arnacantha (M. Bieb.) Podlech subsp. aitosensis (Ivanisch.) Réer & Podlech, a Bulgarian endemic species, was investigated for its phenolic profile and neuroprotective potential. A targeted e…
View article: Multi-target monoamine oxidase-B (MAO-B) inhibitors in the treatment of Parkinson’s disease
Multi-target monoamine oxidase-B (MAO-B) inhibitors in the treatment of Parkinson’s disease Open
Parkinson’s disease (PD) is a fast-advancing disorder of the nervous system, ranking only behind Alzheimer’s disease as the most prevalent neurodegenerative condition associated with aging. Its incidence increases with age – being relative…
View article: Classical Paal-Knorr Cyclization for Synthesis of Pyrrole-Based Aryl Hydrazones and In Vitro/In Vivo Evaluation on Pharmacological Models of Parkinson’s Disease
Classical Paal-Knorr Cyclization for Synthesis of Pyrrole-Based Aryl Hydrazones and In Vitro/In Vivo Evaluation on Pharmacological Models of Parkinson’s Disease Open
Some studies performed in our laboratory on pyrrole and its derivatives pointed towards the enrichment of the evaluations of these promising chemical structures for the potential treatment of neurodegenerative conditions in general and Par…
View article: Synthesis, biological evaluation, and molecular docking of benzhydrazide derivatives
Synthesis, biological evaluation, and molecular docking of benzhydrazide derivatives Open
In the pursuit of discovering and developing compounds with antioxidant and other biological activities, we designed, synthesized, and evaluated 10 hydrazide-hydrazone derivatives of 4-hydroxybenzohydrazide (ohbh1-10) as potential antioxid…
View article: In silico metabolism and toxicity prediction using a knowledge-based approach
In silico metabolism and toxicity prediction using a knowledge-based approach Open
The application of in silico approaches for predicting metabolic pathways and toxicity profiles has significantly advanced drug discovery and chemical risk evaluation. By harnessing developments in cheminformatics, machine learning, and ex…
View article: In silico studies concerning the cytotoxic potential and the inhibition of cytochrome P450 of some bioactive compounds present in Asphodeline lutea root extracts
In silico studies concerning the cytotoxic potential and the inhibition of cytochrome P450 of some bioactive compounds present in Asphodeline lutea root extracts Open
Background and Aims: The roots of Asphodeline lutea are traditionally consumed in the diet of people from Mediterranean countries. The methanol root extracts of A. lutea have been proven to possess cytotoxic activity against the MCF-7 and …
View article: Antioxidant and Neuroprotective Properties of Selected Pyrrole-Containing Azomethine Compounds in Neurotoxicity Models In Vitro
Antioxidant and Neuroprotective Properties of Selected Pyrrole-Containing Azomethine Compounds in Neurotoxicity Models In Vitro Open
Neurodegenerative diseases involve oxidative stress and enzyme dysregulation, necessitating novel neuroprotective agents. This study evaluates the neuroprotective and antioxidant potential of seven pyrrole-based compounds with predicted ra…
View article: Standardization of pharmacognostic characters and phytochemical study of Limeum obovatum vicary
Standardization of pharmacognostic characters and phytochemical study of Limeum obovatum vicary Open
View article: Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents
Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents Open
View article: Investigating the impact of Multiwalled Carbon Nanotubes exposure on enzymatic activities and histopathological variations in Swiss albino mice
Investigating the impact of Multiwalled Carbon Nanotubes exposure on enzymatic activities and histopathological variations in Swiss albino mice Open
View article: Identification and quantitation of Choline in food supplements using high performance liquid chromatography
Identification and quantitation of Choline in food supplements using high performance liquid chromatography Open
A reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the separation and quantitative determination of choline in dietary supplements. The method optimization involved the selection of a P…
View article: Exploring the Antidiabetic Potential of Pyrimidine‐Derived Chalcones: Synthesis, Biological Evaluation, and Molecular Modeling
Exploring the Antidiabetic Potential of Pyrimidine‐Derived Chalcones: Synthesis, Biological Evaluation, and Molecular Modeling Open
In the current research work, we have prepared a series of pyrimidine moiety‐containing molecules due to their promising medicinal profile. First of all, we prepared two acetyl derivatives of pyrimidine ( 15 , 16 ), and then they reacted w…
View article: Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment
Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment Open
Aging is an invincible phenomenon that is a risk factor for the development of neurological disorders such as anxiety, depression, and memory decline that are prominent in aging. The present study aims to evaluate the effect of Niacin (Nn)…
View article: Reusable Magnetic Nanoparticles: A Green System for Synthesis of Pyrrole Scaffolds
Reusable Magnetic Nanoparticles: A Green System for Synthesis of Pyrrole Scaffolds Open
Nowadays, environmentally sustainable organic synthesis is demanding. In this context, nanoparticles are particularly interesting owing to their green synthesis aspects. Specifically, magnetic nanoparticles have been continuously utilized …
View article: Hydrazide-hydrazones as novel antioxidants - in vitro, molecular docking and DFT studies
Hydrazide-hydrazones as novel antioxidants - in vitro, molecular docking and DFT studies Open
The pathogenesis of many diseases, such as obesity, depression, cancer, cataract, and neurodegenerative diseases, is related to the generation of reactive oxygen species (ROS). Structures possessing radical-scavenging properties act as ant…
View article: Neurotoxicity, Neuroprotection, In Vitro MAOA/MAOB Inhibitory Activity Assessment, Molecular Docking, and Permeability Assay Studies of Newly Synthesized Hydrazones Containing a Pyrrole Ring
Neurotoxicity, Neuroprotection, In Vitro MAOA/MAOB Inhibitory Activity Assessment, Molecular Docking, and Permeability Assay Studies of Newly Synthesized Hydrazones Containing a Pyrrole Ring Open
Neurodegenerative diseases such as Parkinson’s and Alzheimer’s continue to be some of the most significant challenges in modern medicine. Recent research related to the molecular mechanisms of parkinsonism has opened up new approaches to a…
View article: Novel Pyrrole Derivatives as Multi-Target Agents for the Treatment of Alzheimer’s Disease: Microwave-Assisted Synthesis, In Silico Studies and Biological Evaluation
Novel Pyrrole Derivatives as Multi-Target Agents for the Treatment of Alzheimer’s Disease: Microwave-Assisted Synthesis, In Silico Studies and Biological Evaluation Open
Considering the complex pathogenesis of Alzheimer’s disease (AD), the multi-target ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, …
View article: Evaluation of the inhibition performance of pyrrole derivatives against CYP450 isoforms
Evaluation of the inhibition performance of pyrrole derivatives against CYP450 isoforms Open
Cytochrome P450 is a heme-containing superfamily accountable for the oxidation of various pharmacologically active drugs. The aim of this study was to conduct in silico and in vitro activity assessments of recently synthesized pyrrole-base…
View article: From Rings to Remedies: Investigating the Structure-Activity Relationship of Macrocyclic Anticancer Agents
From Rings to Remedies: Investigating the Structure-Activity Relationship of Macrocyclic Anticancer Agents Open
The profound pharmacological attributes of macrocyclic compounds have spurred their transformation into pharmaceutical drugs. Within conformationally pre-organized ring structures, the macrocycle’s intricate functions and stereochemical co…
View article: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies of Novel Pyrrole-Based Schiff Bases as Dual Acting MAO/AChE Inhibitors
Synthesis, Biological Evaluation, Molecular Docking and ADME Studies of Novel Pyrrole-Based Schiff Bases as Dual Acting MAO/AChE Inhibitors Open
Considering the complex pathogenesis of Alzheimer’s disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target approach. Thus, a…
View article: In Silico and Chromatographic Methods for Analysis of Biotransformation of Prospective Neuroprotective Pyrrole-Based Hydrazone in Isolated Rat Hepatocytes
In Silico and Chromatographic Methods for Analysis of Biotransformation of Prospective Neuroprotective Pyrrole-Based Hydrazone in Isolated Rat Hepatocytes Open
In the current study, chromatographic and in silico techniques were applied to investigate the biotransformation of ethyl 5-(4-bromophenyl)-1-(2-(2-(2-hydroxybenzylidene) hydrazinyl)-2-oxoethyl)-2-methyl-1H-pyrrole-3-carboxylate (11b) in h…
View article: Microwave-assisted organic synthesis of pyrroles (Review)
Microwave-assisted organic synthesis of pyrroles (Review) Open
The detection of pyrrole rings in numerous organic compounds with various pharmacological activities, emphasizes its huge importance in medicinal chemistry. Thus, the synthesis of pyrroles continues to arouse interest and Paal-Knorr conden…
View article: In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors
In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors Open
Virtual screening is emerging as a highly applied technique and gained prominence as widely used method for the search and identification of potential hits, significantly reducing the time needed to discover novel and effective compounds c…
View article: Biological evaluation, molecular docking and DFT calculations of pyrrole-based derivatives as dual acting AChE/MAO-B inhibitors
Biological evaluation, molecular docking and DFT calculations of pyrrole-based derivatives as dual acting AChE/MAO-B inhibitors Open
Considering the complex pathophysiology of Alzheimer’s disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus…
View article: Synthesis, DFT Study, and In Vitro Evaluation of Antioxidant Properties and Cytotoxic and Cytoprotective Effects of New Hydrazones on SH-SY5Y Neuroblastoma Cell Lines
Synthesis, DFT Study, and In Vitro Evaluation of Antioxidant Properties and Cytotoxic and Cytoprotective Effects of New Hydrazones on SH-SY5Y Neuroblastoma Cell Lines Open
A series of ten new hydrazide–hydrazone derivatives bearing a pyrrole ring were synthesized and structurally elucidated through appropriate spectral characteristics. The target hydrazones were assessed for radical scavenging activity throu…
View article: Structure-Based Design of Novel MAO-B Inhibitors: A Review
Structure-Based Design of Novel MAO-B Inhibitors: A Review Open
With the significant growth of patients suffering from neurodegenerative diseases (NDs), novel classes of compounds targeting monoamine oxidase type B (MAO-B) are promptly emerging as distinguished structures for the treatment of the latte…