Emily A. McHugh
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View article: Pleozymes: Pleiotropic Oxidized Carbon Nanozymes Enhance Cellular Metabolic Flexibility
Pleozymes: Pleiotropic Oxidized Carbon Nanozymes Enhance Cellular Metabolic Flexibility Open
Our group has synthesized a pleiotropic synthetic nanozyme redox mediator we term a “pleozyme” that displays multiple enzymatic characteristics, including acting as a superoxide dismutase mimetic, oxidizing NADH to NAD+, and oxidizing H2S …
View article: Harshly Oxidized Activated Charcoal Enhances Protein Persulfidation with Implications for Neurodegeneration as Exemplified by Friedreich’s Ataxia
Harshly Oxidized Activated Charcoal Enhances Protein Persulfidation with Implications for Neurodegeneration as Exemplified by Friedreich’s Ataxia Open
Harsh acid oxidation of activated charcoal transforms an insoluble carbon-rich source into water-soluble, disc structures of graphene decorated with multiple oxygen-containing functionalities. We term these pleiotropic nano-enzymes as “ple…
View article: SOD1 Is an Integral Yet Insufficient Oxidizer of Hydrogen Sulfide in Trisomy 21 B Lymphocytes and Can Be Augmented by a Pleiotropic Carbon Nanozyme
SOD1 Is an Integral Yet Insufficient Oxidizer of Hydrogen Sulfide in Trisomy 21 B Lymphocytes and Can Be Augmented by a Pleiotropic Carbon Nanozyme Open
Down syndrome (DS) is a multisystemic disorder that includes accelerated aging caused by trisomy 21. In particular, overexpression of cystathionine-β-synthase (CBS) is linked to excess intracellular hydrogen sulfide (H2S), a mitochondrial …
View article: Oxidized Carbon Nanoparticles Enhance Cellular Energetics With Application to Injured Brain
Oxidized Carbon Nanoparticles Enhance Cellular Energetics With Application to Injured Brain Open
Pro‐energetic effects of functionalized, oxidized carbon nanozymes (OCNs) are reported. OCNs, derived from harsh acid oxidation of single‐wall carbon nanotubes or activated charcoal are previously shown to possess multiple nanozymatic acti…
View article: Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome (Adv. Mater. 10/2024)
Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome (Adv. Mater. 10/2024) Open
Oxidized Carbon Nanozymes Trisomy of chromosome 21 (Down Syndrome) generation of toxic excess H2S due to its duplicated enzyme gene. Nanoparticles derived from the harsh acid oxidation of activated charcoal oxidize H2S in mitochondria into…
View article: Nondestructive flash cathode recycling
Nondestructive flash cathode recycling Open
Effective recycling of end-of-life Li-ion batteries (LIBs) is essential due to continuous accumulation of battery waste and gradual depletion of battery metal resources. The present closed-loop solutions include destructive conversion to m…
View article: Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome
Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome Open
Hydrogen sulfide (H 2 S) is a noxious, potentially poisonous, but necessary gas produced from sulfur metabolism in humans. In Down Syndrome (DS), the production of H 2 S is elevated and associated with degraded mitochondrial function. Ther…
View article: Oxidized Activated Charcoal Nanozymes: Synthesis, and Optimization for In Vitro and In Vivo Bioactivity for Traumatic Brain Injury
Oxidized Activated Charcoal Nanozymes: Synthesis, and Optimization for In Vitro and In Vivo Bioactivity for Traumatic Brain Injury Open
Carbon‐based superoxide dismutase (SOD) mimetic nanozymes have recently been employed as promising antioxidant nanotherapeutics due to their distinct properties. The structural features responsible for the efficacy of these nanomaterials a…
View article: Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer
Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer Open
Chronic exposure to airborne carbon black ultrafine (nCB) particles generated from incomplete combustion of organic matter drives IL-17A–dependent emphysema. However, whether and how they alter the immune responses to lung cancer remains u…
View article: High-surface-area corundum nanoparticles by PDC process
High-surface-area corundum nanoparticles by PDC process Open
Source data for "High-surface-area corundum nanoparticles by resistive hotspot-induced phase transformation".
View article: High-surface-area corundum nanoparticles by PDC process
High-surface-area corundum nanoparticles by PDC process Open
Source data for "High-surface-area corundum nanoparticles by resistive hotspot-induced phase transformation".
View article: Machine Learning Guided Synthesis of Flash Graphene
Machine Learning Guided Synthesis of Flash Graphene Open
Advances in nanoscience have enabled the synthesis of nanomaterials, such as graphene, from low‐value or waste materials through flash Joule heating. Though this capability is promising, the complex and entangled variables that govern nano…
View article: Ultrafast and Controllable Phase Evolution by Flash Joule Heating
Ultrafast and Controllable Phase Evolution by Flash Joule Heating Open
Flash Joule heating (FJH), an advanced material synthesis technique, has been used for the production of high-quality carbon materials. Direct current discharge through the precursors by large capacitors has successfully converted carbon-b…
View article: High-Resolution Laser-Induced Graphene from Photoresist
High-Resolution Laser-Induced Graphene from Photoresist Open
The fabrication of patterned graphene electronics at high resolution is an important challenge for many applications in microelectronics. Here, we demonstrate the conversion of positive photoresist (PR), commonly employed in the commercial…
View article: Millisecond Conversion of Metastable 2D Materials by Flash Joule Heating
Millisecond Conversion of Metastable 2D Materials by Flash Joule Heating Open
Controllable phase engineering is vital for precisely tailoring material properties since different phase structures have various electronic states and atomic arrangements. Rapid synthesis of thermodynamically metastable materials, especia…
View article: Flash Graphene Morphologies
Flash Graphene Morphologies Open
Flash Joule heating (FJH) can convert almost any carbon-based precursor into bulk quantities of graphene. This work explores the morphologies and properties of flash graphene (FG) generated from carbon black. It is shown that FG is partial…
View article: Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle
Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle Open
Therapy for intracerebral hemorrhage (ICH) remains elusive, in part dependent on the severity of the hemorrhage itself as well as multiple deleterious effects of blood and its breakdown products such as hemin and free iron. While oxidative…
View article: Catalytic oxidation and reduction reactions of hydrophilic carbon clusters with NADH and cytochrome C: features of an electron transport nanozyme
Catalytic oxidation and reduction reactions of hydrophilic carbon clusters with NADH and cytochrome C: features of an electron transport nanozyme Open
PEGylated hydrophilic carbon clusters are electron transfer catalysts between NADH and cytochrome C.