Emily A. Voigt
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View article: Self-amplifying RNA-based activation of HIV-1 broadly neutralizing antibody B cell precursors 2690
Self-amplifying RNA-based activation of HIV-1 broadly neutralizing antibody B cell precursors 2690 Open
Description Elicitation of broadly HIV neutralizing antibody (Ab) responses requires sequential immunizations with specifically designed HIV Env-derived proteins. Such constructs are presently in pre-clinical and clinical evaluation, but t…
View article: The ID93 + GLA-3M-052-LS vaccine candidate elicits mucosal and systemic immunogenicity and protective efficacy against <i>Mycobacterium tuberculosis</i> challenge in BCG-primed Collaborative Cross inbred mice
The ID93 + GLA-3M-052-LS vaccine candidate elicits mucosal and systemic immunogenicity and protective efficacy against <i>Mycobacterium tuberculosis</i> challenge in BCG-primed Collaborative Cross inbred mice Open
New vaccine approaches are needed against tuberculosis (TB). We sought to optimize mucosal immunogenicity and protective efficacy by modulating the adjuvant component and route of immunization of a next-generation TB vaccine using the reco…
View article: An intranasally- and intramuscularly-deliverable nanostructured lipid carrier-replicon RNA vaccine drives protective systemic and mucosal immunity
An intranasally- and intramuscularly-deliverable nanostructured lipid carrier-replicon RNA vaccine drives protective systemic and mucosal immunity Open
A nucleic acid vaccine platform that could be flexibly administered either intranasally or intramuscularly could be a valuable new tool for epidemic and pandemic response, combining rapid antigen adaptability with optimal induction of syst…
View article: A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses
A bivalent self-amplifying RNA vaccine against yellow fever and Zika viruses Open
Introduction Yellow fever (YFV) and Zika (ZIKV) viruses cause significant morbidity and mortality, despite the existence of an approved YFV vaccine and the development of multiple ZIKV vaccine candidates to date. New technologies may impro…
View article: A Spray Dried Replicon Vaccine Platform for Pandemic Response
A Spray Dried Replicon Vaccine Platform for Pandemic Response Open
The recent COVID-19 pandemic, as well as the threat of a global pandemic caused by H5N1 avian influenza virus, has highlighted the need for the development of thermostable vaccines that can be manufactured and distributed rapidly to combat…
View article: Development of an Intranasally- and Intramuscularly-Administrable Replicon Vaccine Efficacious Against H5N1 Influenza Virus
Development of an Intranasally- and Intramuscularly-Administrable Replicon Vaccine Efficacious Against H5N1 Influenza Virus Open
The risk of a respiratory viral pandemic is significant, including from the now widespread panzootic H5N1 influenza virus, highlighting the need for effective, stable, and inexpensive vaccine technologies that elicit strongly protective im…
View article: An intranasal, NLC-delivered self-amplifying RNA vaccine establishes protective immunity against pre-pandemic H5N1 and H7N9 influenza
An intranasal, NLC-delivered self-amplifying RNA vaccine establishes protective immunity against pre-pandemic H5N1 and H7N9 influenza Open
Seasonal and pandemic influenzas are continuous threats to human health, requiring rapid development of vaccines to multiple evolving viral strains. New RNA vaccine technologies have the adaptability and manufacturability to facilitate pan…
View article: Optimizing immunogenicity and product presentation of a SARS-CoV-2 subunit vaccine composition: effects of delivery route, heterologous regimens with self-amplifying RNA vaccines, and lyophilization
Optimizing immunogenicity and product presentation of a SARS-CoV-2 subunit vaccine composition: effects of delivery route, heterologous regimens with self-amplifying RNA vaccines, and lyophilization Open
Introduction Dozens of vaccines have been approved or authorized internationally in response to the ongoing SARS-CoV-2 pandemic, covering a range of modalities and routes of delivery. For example, mucosal delivery of vaccines via the intra…
View article: Exploring yeast glucans for vaccine enhancement: Sustainable strategies for overcoming adjuvant challenges in a SARS-CoV-2 model
Exploring yeast glucans for vaccine enhancement: Sustainable strategies for overcoming adjuvant challenges in a SARS-CoV-2 model Open
Vaccine adjuvants are important for enhancing vaccine efficacy, and although aluminium salts (Alum) are the most used, their limited ability to induce specific immune responses has spurred the search for new adjuvants. However, many adjuva…
View article: Choice of adjuvant and antigen composition alters the immunogenic profile of a SARS-CoV-2 subunit vaccine
Choice of adjuvant and antigen composition alters the immunogenic profile of a SARS-CoV-2 subunit vaccine Open
Introduction: Since their introduction, adjuvanted recombinant subunit vaccines against COVID-19 have played a pivotal role in protecting global populations. Optimizing the immune response’s quality, amplitude, and durability to these vacc…
View article: Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques
Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques Open
Type I interferons (IFN-I) are critical mediators of innate control of viral infections but also drive the recruitment of inflammatory cells to sites of infection, a key feature of severe coronavirus disease 2019. Here, IFN-I signaling was…
View article: Author Correction: A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
Author Correction: A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability Open
View article: Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission
Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission Open
While mRNA vaccines have been effective in combating SARS-CoV-2, waning of vaccine-induced antibody responses and lack of vaccine-induced respiratory tract immunity contribute to ongoing infection and transmission. In this work, we compare…
View article: A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability Open
mRNA vaccines were the first to be authorized for use against SARS-CoV-2 and have since demonstrated high efficacy against serious illness and death. However, limitations in these vaccines have been recognized due to their requirement for …
View article: Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies
Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies Open
We assessed if immune responses are enhanced in CD-1 mice by heterologous vaccination with two different nucleic acid-based COVID-19 vaccines: a next-generation human adenovirus serotype 5 (hAd5)-vectored dual-antigen spike (S) and nucleoc…
View article: A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability Open
mRNA vaccines were the first to be authorized for use against SARS-CoV-2 and have since demonstrated high efficacy against serious illness and death. However, limitations in these vaccines have been recognized due to their requirement for …
View article: A flexible, thermostable nanostructured lipid carrier platform for RNA vaccine delivery
A flexible, thermostable nanostructured lipid carrier platform for RNA vaccine delivery Open
Current RNA vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are limited by instability of both the RNA and the lipid nanoparticle delivery system, requiring storage at -20°C or -70°C and compromising universal…
View article: Live-attenuated RNA hybrid vaccine technology provides single-dose protection against Chikungunya virus
Live-attenuated RNA hybrid vaccine technology provides single-dose protection against Chikungunya virus Open
View article: A Thermostable, Flexible RNA Vaccine Delivery Platform for Pandemic Response
A Thermostable, Flexible RNA Vaccine Delivery Platform for Pandemic Response Open
Current RNA vaccines against SARS-CoV-2 are limited by instability of both the RNA and the lipid nanoparticle delivery system, requiring storage at −20°C or −70°C and compromising universally accessible vaccine distribution. This study dem…
View article: Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses
Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses Open
We conducted a large genome-wide association study (GWAS) of the immune responses to primary smallpox vaccination in a combined cohort of 1,653 subjects. We did not observe any polymorphisms associated with standard vaccine response outcom…
View article: Intramuscular Delivery of Replicon RNA Encoding ZIKV-117 Human Monoclonal Antibody Protects against Zika Virus Infection
Intramuscular Delivery of Replicon RNA Encoding ZIKV-117 Human Monoclonal Antibody Protects against Zika Virus Infection Open
Monoclonal antibody (mAb) therapeutics are an effective modality for the treatment of infectious, autoimmune, and cancer-related diseases. However, the discovery, development, and manufacturing processes are complex, resource-consuming act…
View article: Polymorphisms in STING affect human innate immune responses to poxviruses
Polymorphisms in STING affect human innate immune responses to poxviruses Open
We conducted a large genome-wide association study (GWAS) of the immune responses to primary smallpox vaccination in a combined cohort of > 1,600 subjects. We identified a cluster of SNPs on chromosome 5 (5q31.2) that were significantly as…
View article: Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination
Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination Open
Background: Sex differences in immune responses to influenza vaccine may impact efficacy across populations. Methods: In a cohort of 138 older adults (50-74 years old), we measured influenza A/H1N1 antibody titers, B-cell ELI…
View article: Transcriptomic signatures of cellular and humoral immune responses in older adults after seasonal influenza vaccination identified by data-driven clustering
Transcriptomic signatures of cellular and humoral immune responses in older adults after seasonal influenza vaccination identified by data-driven clustering Open
View article: Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus–Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination
Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus–Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination Open
Rubella vaccination induces widely variable immune responses in vaccine recipients. While rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up to 5% of individuals do not achieve or maintain long-…
View article: Intention to leave and employee turnover: expanding understanding of key antecedents in the modern workforce
Intention to leave and employee turnover: expanding understanding of key antecedents in the modern workforce Open
This research expanded understanding of the key antecedents of intention to leave and employee turnover in a sample of retail banking employees from a large Australian-based financial institution. In three empirical studies, this research …
View article: Rapid induction and persistence of paracrine-induced cellular antiviral states arrest viral infection spread in A549 cells
Rapid induction and persistence of paracrine-induced cellular antiviral states arrest viral infection spread in A549 cells Open
View article: Defending against smallpox: a focus on vaccines
Defending against smallpox: a focus on vaccines Open
Smallpox has shaped human history, from the earliest human civilizations well into the 20th century. With high mortality rates, rapid transmission, and serious long-term effects on survivors, smallpox was a much-feared disease. The eradica…
View article: Kinetic Differences and Synergistic Antiviral Effects Between Type I and Type III Interferon Signaling Indicate Pathway Independence
Kinetic Differences and Synergistic Antiviral Effects Between Type I and Type III Interferon Signaling Indicate Pathway Independence Open
The spread of acute respiratory viral infections is controlled by type I and III interferon (IFN) signaling. While the mechanisms of type I IFN signaling have been studied in detail, features that distinguish type III IFN signaling remain …
View article: Genome rearrangement affects RNA virus adaptability on prostate cancer cells
Genome rearrangement affects RNA virus adaptability on prostate cancer cells Open
Gene order is often highly conserved within taxonomic groups, such that organisms with rearranged genomes tend to be less fit than wild type gene orders, and suggesting natural selection favors genome architectures that maximize fitness. B…