Emily C. Erickson
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View article: Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation Open
More than 50% of human tumors display hyperactivation of the serine/threonine kinase AKT. Despite evidence of clinical efficacy, the therapeutic window of the current generation of AKT inhibitors could be improved. Here, we report the deve…
View article: Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1 Open
Adenosine monophosphate–activated protein kinase (AMPK) activity is stimulated to promote metabolic adaptation upon energy stress. However, sustained metabolic stress may cause cell death. The mechanisms by which AMPK dictates cell death a…
View article: Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation
Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation Open
Over 50% of human tumors display hyperactivation of the serine/threonine kinase AKT. Despite evidence of clinical efficacy, there remains scope to improve upon the therapeutic window of the current generation of AKT inhibitors. Here we rep…
View article: Can Improved Use of Biomarkers Alter the Fate of PI3K Pathway Inhibitors in the Clinic?
Can Improved Use of Biomarkers Alter the Fate of PI3K Pathway Inhibitors in the Clinic? Open
The high frequency of PI3K pathway alterations in cancer has motivated numerous efforts to develop drugs targeting this network. Although many potent and selective inhibitors have been developed and evaluated in preclinical models, their p…
View article: Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype Open
A PI3Kα-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA , the gene encoding p110α. Preclinical studies have suggested that the PI3K/AKT/mTOR signaling pathway influences stemness, a ded…
View article: Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype.
Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype. Open
A PI3Kα-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA, the gene encoding p110α. Preclinical studies have suggested that the PI3K/AKT/mTOR signaling pathway influences stemness, a dedi…
View article: Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling Open
SUMMARY The PI3K/AKT signaling cascade is one of the most commonly dysregulated pathways in cancer, with over half of tumors exhibiting aberrant AKT activation. Although potent small molecule AKT inhibitors have entered clinical trials, ro…
View article: CLOCK regulates mammary epithelial cell growth and differentiation
CLOCK regulates mammary epithelial cell growth and differentiation Open
Circadian clocks influence virtually all physiological processes, including lactation. Here, we investigate the role of the CLOCK gene in regulation of mammary epithelial cell growth and differentiation. Comparison of mammary morphology in…