Emily Chiem
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View article: Language network functional connectivity in infancy predicts developmental language trajectories
Language network functional connectivity in infancy predicts developmental language trajectories Open
Although developmental language delays affect approximately 10% of children in the general population, the neurodevelopmental mechanisms that support normative language acquisition, and atypicalities that may predict later language delay, …
View article: Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development
Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development Open
Although the cerebellum is now recognized for its crucial role in non-motor functions such as language, perceptual processes, social communication, and executive function in adults, it is often overlooked in studies of non-motor behavioral…
View article: Scheduled feeding improves sleep in a mouse model of Huntington’s disease
Scheduled feeding improves sleep in a mouse model of Huntington’s disease Open
Sleep disturbances are common features of neurodegenerative disorders including Huntington’s disease (HD). Sleep and circadian disruptions are recapitulated in animal models, providing the opportunity to evaluate the effectiveness of circa…
View article: Differential inflammatory profiles in carriers of reciprocal 22q11.2 copy number variants
Differential inflammatory profiles in carriers of reciprocal 22q11.2 copy number variants Open
Our results suggest that CNVs at the 22q11.2 locus may have differential effects on inflammatory processes related to IL-8, a key mediator of inflammation produced by macrophages and microglia. Further, these IL-8-mediated inflammatory pro…
View article: Scheduled feeding improves sleep in a mouse model of Huntington’s disease
Scheduled feeding improves sleep in a mouse model of Huntington’s disease Open
Sleep disturbances are common features of neurodegenerative disorders including Huntington’s disease (HD). The sleep and circadian disruptions are recapitulated in animal models, and these models provide the opportunity to evaluate whether…
View article: Sex differences in sleep architecture in a mouse model of Huntington's disease
Sex differences in sleep architecture in a mouse model of Huntington's disease Open
Sleep and circadian rhythm disturbances are common features of Huntington's disease (HD). HD is an autosomal dominant neurodegenerative disorder that affects men and women in equal numbers, but some epidemiological studies as well as precl…
View article: 0778 Functional thalamo-cortical connectivity relates to sleep-onset problems in early infancy
0778 Functional thalamo-cortical connectivity relates to sleep-onset problems in early infancy Open
Introduction Healthy sleep patterns are crucial for proper brain development in infancy. However, little is known about the relationship between early sleep disturbances and functional brain connectivity. The thalamus plays a critical role…
View article: Sex Differences in Sleep Phenotypes in the BACHD Mouse Model of Huntington’s Disease
Sex Differences in Sleep Phenotypes in the BACHD Mouse Model of Huntington’s Disease Open
Sleep and circadian rhythm disturbances are common features of Huntington’s disease (HD). HD is an autosomal dominant neurodegenerative disorder that affects men and women in equal numbers, but some epidemiological studies as well as precl…
View article: 0495 Sleep Disturbance Features Differentially Influence Inflammatory Markers in Adolescents
0495 Sleep Disturbance Features Differentially Influence Inflammatory Markers in Adolescents Open
Introduction Sleep disruption has profound effects on immune function. Many adolescents do not get adequate amounts of sleep each night, and chronic sleep disturbance has been associated with increased risk of several inflammatory diseases…
View article: 0619 The Relationship Between Sleep Disturbance and Inflammatory Markers in Individuals with 22q11.2 Copy Number Variations
0619 The Relationship Between Sleep Disturbance and Inflammatory Markers in Individuals with 22q11.2 Copy Number Variations Open
Introduction The 22q11.2 locus contains genes critical for brain development. Individuals with copy number variations (i.e. a deletion or duplication; CNV) at this locus have greatly increased risk of developmental neuropsychiatric disorde…
View article: Targeted Genetic Reduction of Mutant Huntingtin Lessens Cardiac Pathology in the BACHD Mouse Model of Huntington's Disease
Targeted Genetic Reduction of Mutant Huntingtin Lessens Cardiac Pathology in the BACHD Mouse Model of Huntington's Disease Open
Individuals affected by Huntington's disease (HD) present with progressive degeneration that results in a wide range of symptoms, including cardiovascular (CV) dysfunction. The huntingtin gene ( HTT ) and its product are ubiquitously expre…
View article: 0309 Stress Induced Nitric Oxide Synthase Activation in the Basal Forebrain is a Result of Sleep Loss
0309 Stress Induced Nitric Oxide Synthase Activation in the Basal Forebrain is a Result of Sleep Loss Open
Introduction The mechanisms underlying the reciprocal relationship between stress and sleep are unclear. Nitric oxide, a diffusible signaling molecule, plays an important role in physiological stress responses and sleep. The medial septum …
View article: 0426 Time Restricted Feeding Consolidates Sleep in the BACHD Mouse Model of Huntington’s Disease
0426 Time Restricted Feeding Consolidates Sleep in the BACHD Mouse Model of Huntington’s Disease Open
Introduction Disturbances in the daily sleep-wake cycle are common in individuals with neurodegenerative disorders. Huntington’s disease (HD) is a genetic neurodegenerative disorder in which patients exhibit a variety of impairments that i…