Emily E. Hesketh
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View article: Improving communication for interdisciplinary teams working on storage of digital information in DNA
Improving communication for interdisciplinary teams working on storage of digital information in DNA Open
Close collaboration between specialists from diverse backgrounds and working in different scientific domains is an effective strategy to overcome challenges in areas that interface between biology, chemistry, physics and engineering. Commu…
View article: Acute Liver Injury Is Independent of B Cells or Immunoglobulin M
Acute Liver Injury Is Independent of B Cells or Immunoglobulin M Open
IgM deposition appears to be common feature of both human and murine sterile liver injury. However, neither IgM nor B cells, play a significant role in the development of or resolution from acute liver injury. T cells appear to be key medi…
View article: Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes
Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes Open
Autoimmunity is associated with defective phagocytic clearance of apoptotic cells. IgM deficient mice exhibit an autoimmune phenotype consistent with a role for circulating IgM antibodies in apoptotic cell clearance. We have extensively ch…
View article: IgM antibodies exhibit preferential binding to apoptotic and non-apoptotic nucleated cells
IgM antibodies exhibit preferential binding to apoptotic and non-apoptotic nucleated cells Open
Data set characterising IgM antibody binding to non-apoptotic, apoptotic and permeable murine/human thymocytes and murine erythrocytes. Methodology used consisted of flow cytometry, confocal and electron microscopy. With the exception of t…