Emily Esakov
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View article: Activating the immune system is essential for the efficacy of heated intraperitoneal cisplatin in a murine model of advanced epithelial ovarian cancer (008)
Activating the immune system is essential for the efficacy of heated intraperitoneal cisplatin in a murine model of advanced epithelial ovarian cancer (008) Open
View article: LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer
LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer Open
Poly-ADP Ribose Polymerase (PARP) targeted therapy is clinically approved for the treatment of homologous recombination (HR) repair deficient tumors. The remarkable success of this therapy in the treatment of HR repair deficient cancers ha…
View article: LCK Facilitates DNA Damage Repair by Stabilizing RAD51 and BRCA1 in the Nucleus of Chemoresistant Ovarian Cancer
LCK Facilitates DNA Damage Repair by Stabilizing RAD51 and BRCA1 in the Nucleus of Chemoresistant Ovarian Cancer Open
Poly-ADP Ribose Polymerase (PARP) targeted therapy is clinically approved for the treatment of homologous recombination (HR) repair deficient tumors. The remarkable success of this therapy in the treatment of HR repair deficient cancers ha…
View article: Abstracts
Abstracts Open
View article: LCK Regulates Homologous Recombination DNA Repair and Targeting Enhances PARPi Utility in HR Proficient Ovarian Cancer
LCK Regulates Homologous Recombination DNA Repair and Targeting Enhances PARPi Utility in HR Proficient Ovarian Cancer Open
View article: Disruption of the Gut Microbiota Attenuates Epithelial Ovarian Cancer Sensitivity to Cisplatin Therapy
Disruption of the Gut Microbiota Attenuates Epithelial Ovarian Cancer Sensitivity to Cisplatin Therapy Open
Background: Epithelial Ovarian Cancer (EOC) is the second most common gynecologic malignancy in the United States, but the leading cause of gynecologic cancer death. Despite many achieving remission with first-line therapy, up to 80% of pa…
View article: Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1
Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1 Open
CEACAM1 regulates endothelial barrier integrity. Because insulin signaling in extrahepatic target tissues is regulated by insulin transport through the endothelium, we aimed at investigating the metabolic role of endothelial CEACAM1. To th…
View article: Activation of Adaptive Immune Cells is an Early Response to Hyperthermic Intraperitoneal Chemotherapy Treatment in Ovarian Cancer
Activation of Adaptive Immune Cells is an Early Response to Hyperthermic Intraperitoneal Chemotherapy Treatment in Ovarian Cancer Open
Hyperthermic intraperitoneal chemotherapy (HIPEC) has significantly increased the survival of epithelial ovarian (EOC) patients and is being adopted as a standard clinical approach for managing these tumors. However, while the clinical res…
View article: A Novel Non-Invasive Epithelial Ovarian Cancer Mouse Model Of Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
A Novel Non-Invasive Epithelial Ovarian Cancer Mouse Model Of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Open
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) in combination with interval cytoreductive surgery increases the overall survival of epithelial ovarian cancer (EOC) patients with advanced disease. Despite its proven benefits, …
View article: Pretreatment with LCK inhibitors chemosensitizes cisplatin‐resistant endometrioid ovarian tumors
Pretreatment with LCK inhibitors chemosensitizes cisplatin‐resistant endometrioid ovarian tumors Open
Background Ovarian cancer is the most fatal gynecologic malignancy in the United States. While chemotherapy is effective in the vast majority of ovarian cancer patients, recurrence and resistance to standard systemic therapy is nearly inev…
View article: Islet Dysfunction in a Novel Transgenic Model of T Cell Insulitis
Islet Dysfunction in a Novel Transgenic Model of T Cell Insulitis Open
The newly established CD3FLAG-mIR transgenic mouse model on a C57Bl/6 background has a FLAG tag on the mouse Insulin Receptor (mIR), specifically on T cells, as the FLAG-tagged mIR gene was engineered behind CD3 promoter and enhancer. The …
View article: LCK Regulates Homologous Recombination DNA Repair Identifying a New Target for Sensitizing PARP Inhibitors in HR Proficient Ovarian Cancer
LCK Regulates Homologous Recombination DNA Repair Identifying a New Target for Sensitizing PARP Inhibitors in HR Proficient Ovarian Cancer Open
Poly-ADP Ribose Polymerase (PARP) targeted therapy is clinically approved for the treatment of homologous recombination (HR) repair deficient tumors. The remarkable success in treatment of HR repair deficient cancers has not translated to …
View article: Insulin Receptor–Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice
Insulin Receptor–Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice Open
Insulin receptor (IR) expression on the T cell surface can indicate an activated state; however, the IR is also chemotactic, enabling T cells with high IR expression to physically move toward insulin. In humans with type 1 diabetes (T1D) a…
View article: Pretreatment with LCK Inhibitors Chemosensitizes Cisplatin-Resistant Endometrioid Ovarian Tumors
Pretreatment with LCK Inhibitors Chemosensitizes Cisplatin-Resistant Endometrioid Ovarian Tumors Open
Background: Ovarian cancer is the most fatal gynecologic malignancy in the United States. While chemotherapy is effective in the vast majority of ovarian cancer patients, recurrence and resistance to standard systemic therapy is nearly ine…
View article: Single-Cell Analysis of Hyperthermic Intraperitoneal Chemotherapy Treated Tumors Reveals Distinct Cellular and Molecular Responses
Single-Cell Analysis of Hyperthermic Intraperitoneal Chemotherapy Treated Tumors Reveals Distinct Cellular and Molecular Responses Open
Summary Hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a clinical regimen that prolongs overall survival for patients with advanced Epithelial Ovarian Cancer (EOC). However, the mechanism of action of HIPEC remains poorly…
View article: Disruption of the Gut Microbiota Attenuates Epithelial Ovarian Cancer Sensitivity to Cisplatin Therapy
Disruption of the Gut Microbiota Attenuates Epithelial Ovarian Cancer Sensitivity to Cisplatin Therapy Open
Background: Epithelial Ovarian Cancer (EOC) is the second most common gynecologic malignancy in the United States, but the leading cause of gynecologic cancer death. Despite many achieving remission with first-line therapy, up to 80% of pa…
View article: A NOVEL LOW-DOSE COMBINATION DRUG THERAPY FOR ENDOMETRIOSIS THAT INCREASES PROGESTERONE RECEPTOR TO ENHANCE PROGESTIN EFFICACY
A NOVEL LOW-DOSE COMBINATION DRUG THERAPY FOR ENDOMETRIOSIS THAT INCREASES PROGESTERONE RECEPTOR TO ENHANCE PROGESTIN EFFICACY Open
View article: Signaling within the epithelial ovarian cancer tumor microenvironment: the challenge of tumor heterogeneity
Signaling within the epithelial ovarian cancer tumor microenvironment: the challenge of tumor heterogeneity Open
Epithelial ovarian cancer (EOC) is a leading cause of cancer death in women. Standard of care treatment has remained platinum-containing cytotoxic chemotherapy for over three decades. Among the central challenges in treating ovarian CA are…
View article: Pretreatment with LCK Inhibitors Chemosensitizes Cisplatin-Resistant Endometrioid Ovarian Tumors
Pretreatment with LCK Inhibitors Chemosensitizes Cisplatin-Resistant Endometrioid Ovarian Tumors Open
Objective To evaluate LCK inhibitors (LCKi) as chemosensitizing agents for platinum-resistant endometrioid ovarian carcinoma. Methods KM Plotter survival data was obtained for endometrioid ovarian cancer based on LCK mRNA expression. Cispl…
View article: Disruption of the gut microbiota attenuates epithelial ovarian cancer sensitivity to cisplatin therapy
Disruption of the gut microbiota attenuates epithelial ovarian cancer sensitivity to cisplatin therapy Open
Epithelial Ovarian Cancer (EOC) is the leading cause of gynecologic cancer death. Despite many patients achieving remission with first-line therapy, up to 80% of patients will recur and require additional treatment. Retrospective clinical …
View article: Use of Transabdominal Ultrasound for the detection of intra-peritoneal tumor engraftment and growth in mouse xenografts of epithelial ovarian cancer
Use of Transabdominal Ultrasound for the detection of intra-peritoneal tumor engraftment and growth in mouse xenografts of epithelial ovarian cancer Open
TAUS is highly discriminatory for monitoring EOC in pre-clinical murine model, allowing for detection of tumor dimension as small as 2 mm and as early as seven days post-injection compared to IVIS. In addition, TAUS provides relevant infor…
View article: Use of Transabdominal Ultrasound for the Detection of Intra-Peritoneal Tumor Engraftment and Growth in Mouse Xenografts of Epithelial Ovarian Cancer
Use of Transabdominal Ultrasound for the Detection of Intra-Peritoneal Tumor Engraftment and Growth in Mouse Xenografts of Epithelial Ovarian Cancer Open
Objective To evaluate intraperitoneal (IP) tumor engraftment, metastasis and growth in a pre-clinical murine epithelial ovarian cancer (EOC) model using both transabdominal ultrasound (TAUS) and bioluminescence in vivo imaging system (IVIS…
View article: Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer
Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer Open
Epigenetic modifications are known to play critical roles in the expression of genes related to differentiation and dedifferentiation. Histone lysine demethylase KDM5B (PLU-1) catalyzes the demethylation of histone H3 on Lys 4 (H3K4), whic…
View article: Prostaglandin E2 activates complement protein CD55 to enhance cell adhesion in endometriosis
Prostaglandin E2 activates complement protein CD55 to enhance cell adhesion in endometriosis Open
View article: Therapeutic strategies to induce ERα in luminal breast cancer to enhance tamoxifen efficacy
Therapeutic strategies to induce ERα in luminal breast cancer to enhance tamoxifen efficacy Open
Breast cancer is the most prevalent malignancy and second leading cause of death in women worldwide, with hormone receptor-positive luminal breast cancers being the most widespread subtype. While these tumors are generally amenable to endo…
View article: Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis
Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis Open
View article: Characterization of a Novel Pre-Diabetic Murine Model for Type 1 Diabetes
Characterization of a Novel Pre-Diabetic Murine Model for Type 1 Diabetes Open
View article: Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue
Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue Open
CEACAM1 promotes insulin extraction, an event that occurs mainly in liver. Phenocopying global Ceacam1 null mice (Cc1(-/-) ), C57/BL6J mice fed a high-fat (HF) diet exhibited reduced hepatic CEACAM1 levels and impaired insulin clearance, f…