Emily Fraser
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View article: CARRIAGE study - a prospective cohort study of determinants of Staphylococcus aureus nasal colonisation in healthy adults in England.
CARRIAGE study - a prospective cohort study of determinants of Staphylococcus aureus nasal colonisation in healthy adults in England. Open
Background Around 30% of humans carry Staphylococcus aureus in their nose. S. aureus is an important cause of disease, and carriers are at greater risk of bacteraemia than non-carriers. Why some people carry S. aureus while others never do…
View article: Single-cell lipidomics: protocol development for reliable cellular profiling using capillary sampling
Single-cell lipidomics: protocol development for reliable cellular profiling using capillary sampling Open
Single-cell lipidomics enables detailed analysis of the lipidomes of cells, but is challenged by small sample volumes, the risk of background interference and a lack of validation data. This work explores the impact of various parameters o…
View article: Clinical Applications of Hyperpolarised Xenon-129 MRI
Clinical Applications of Hyperpolarised Xenon-129 MRI Open
Conventional imaging modalities, the X-ray and CT, are essential diagnostic tools in respiratory medicine, providing qualitative information regarding the pattern and extent of pulmonary pathology. Neither provide information regarding the…
View article: Using data collected from structured light plethysmography to differentiate breathing pattern disorder from normal breathing: A study group report
Using data collected from structured light plethysmography to differentiate breathing pattern disorder from normal breathing: A study group report Open
This report relates to a study group hosted by the EPSRC funded network, Integrating data-driven BIOphysical models into REspiratory MEdicine (BIOREME), and supported by SofTMech and Innovate UK, Business Connect. This report summarises th…
View article: Characterization of baseline symptoms and functional impairments in a large cohort of outpatients attending a long covid rehabilitation clinic in the United Kingdom
Characterization of baseline symptoms and functional impairments in a large cohort of outpatients attending a long covid rehabilitation clinic in the United Kingdom Open
Objective: In response to the high prevalence and morbidity associated with long COVID (LC), outpatient rehabilitation programmes were created across jurisdictions. We aimed to characterize baseline symptoms and impairments of patients att…
View article: SUN-129 Adverse Events and Toxicity Associated with Selective Androgen Receptor Modulators
SUN-129 Adverse Events and Toxicity Associated with Selective Androgen Receptor Modulators Open
A. Joshi: None. E. Fraser: None. D.F. Kaune: None. P. Leff: None. S. Lee: None. M. Hazin: None. Background: Selective Androgen Receptor Modulators (SARMs) are a class of androgen receptor ligands that bind to targeted androgen receptors in…
View article: SUN-222 Pioglitazone: An Underutilized Treatment of Diabetes Concurrent With NASH
SUN-222 Pioglitazone: An Underutilized Treatment of Diabetes Concurrent With NASH Open
T.A. Alomar: None. A. Joshi: None. E. Ponce: None. D.F. Kaune: None. E. Fraser: None. S. Alomar: None. M. Hazin: None. Introduction: Non-alcoholic steatohepatitis (NASH) and diabetes (DM) are two closely linked conditions that have been sh…
View article: Improving quality in adult long covid services: Findings from the LOCOMOTION quality improvement collaborative
Improving quality in adult long covid services: Findings from the LOCOMOTION quality improvement collaborative Open
The protracted form of COVID-19 known as 'long covid' was first described in 2020. Its symptoms, course and prognosis vary widely; some patients have a multi-system, disabling and prolonged illness. In 2021, ring-fenced funding was provide…
View article: Long COVID is associated with severe cognitive slowing
Long COVID is associated with severe cognitive slowing Open
Background COVID-19 survivors may suffer from a wide range of chronic cognitive symptoms for months or years as part of post-COVID-19 conditions (PCC). To date, there is no definitive objective cognitive marker for PCC. We hypothesised tha…
View article: S20 Long-COVID: a multi-faceted syndrome explored in the EXPLAIN study (HypErpolarised xenon magnetic resonance PuLmonary ImAging In PatieNts with Long-COVID)
S20 Long-COVID: a multi-faceted syndrome explored in the EXPLAIN study (HypErpolarised xenon magnetic resonance PuLmonary ImAging In PatieNts with Long-COVID) Open
Background Never hospitalised Long-COVID(NHLC) patients are significantly affected by debilitating symptoms. EXPLAIN is a prospective, multi-centre, observational cohort study investigating breathlessness in these patients, comparing multi…
View article: S72 Specific thoracic CT pattern of perihilar conglomeration and consolidation is associated with development of lung fibrosis in pulmonary sarcoidosis
S72 Specific thoracic CT pattern of perihilar conglomeration and consolidation is associated with development of lung fibrosis in pulmonary sarcoidosis Open
Background Approximately 20% of patients with pulmonary sarcoidosis develop fibrosis. There is currently no predictor of fibrosis. Aims We questioned if a specific radiological feature were associated with development of fibrosis in pulmon…
View article: Neutrophil levels correlate with quantitative extent and progression of fibrosis in IPF: results of a single-centre cohort study
Neutrophil levels correlate with quantitative extent and progression of fibrosis in IPF: results of a single-centre cohort study Open
Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis. Clinical studies have demonstrated association between different blood leucocytes and mortality and forced vital capacity (FVC) decl…
View article: Neutrophil levels correlate with quantitative extent and progression of fibrosis in IPF: results of a single-centre cohort study
Neutrophil levels correlate with quantitative extent and progression of fibrosis in IPF: results of a single-centre cohort study Open
Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis. Clinical studies have demonstrated association between different blood leukocytes and mortality and FVC decline. Here we question wh…
View article: Persistence of inflammatory and vascular mediators 5 months after hospitalization with COVID-19 infection
Persistence of inflammatory and vascular mediators 5 months after hospitalization with COVID-19 infection Open
Background and aim In acute severe COVID-19, patients present with lung inflammation and vascular injury, accompanied by an exaggerated cytokine response. In this study, our aim was to describe the inflammatory and vascular mediator profil…
View article: Management of Sarcoidosis: When to Treat, How to Treat and for How Long?
Management of Sarcoidosis: When to Treat, How to Treat and for How Long? Open
Purpose of Review This review draws together recent publications, consensus statements on sarcoidosis and our 25-year collective experience in managing this disease. We focus on pulmonary sarcoidosis, highlighting recent and established co…
View article: Increased monocyte level is a risk factor for radiological progression in patients with early fibrotic interstitial lung abnormality
Increased monocyte level is a risk factor for radiological progression in patients with early fibrotic interstitial lung abnormality Open
Background Interstitial lung abnormalities (ILA) are specific spatial patterns on computed tomography (CT) scan potentially compatible with early interstitial lung disease. A proportion will progress; management involves risk stratificatio…
View article: Lung Abnormalities Detected with Hyperpolarized <sup>129</sup> Xe MRI in Patients with Long COVID
Lung Abnormalities Detected with Hyperpolarized <sup>129</sup> Xe MRI in Patients with Long COVID Open
Background Post-COVID-19 condition encompasses symptoms following COVID-19 infection that linger at least 4 weeks after the end of active infection. Symptoms are wide ranging, but breathlessness is common. Purpose To determine if the previ…
View article: Weight loss during ambulatory tube weaning: don’t put the feeds back up
Weight loss during ambulatory tube weaning: don’t put the feeds back up Open
Objective To describe the prevalence of weight loss during tube weaning and its impact on wean duration and growth. Setting Tertiary feeding clinic, UK. Patients All children seen for weaning from long-term enteral feeding between 2008 and…
View article: The Investigation of Pulmonary Abnormalities using Hyperpolarised Xenon Magnetic Resonance Imaging in Patients with Long-COVID
The Investigation of Pulmonary Abnormalities using Hyperpolarised Xenon Magnetic Resonance Imaging in Patients with Long-COVID Open
Background Long-COVID is an umbrella term used to describe ongoing symptoms following COVID-19 infection after four weeks. Symptoms are wide-ranging but breathlessness is one of the most common and can persist for months after the initial …
View article: Persistent pulmonary disease after acute covid-19
Persistent pulmonary disease after acute covid-19 Open
Lingering pathology contributes to a wider picture of poor health after hospital discharge
View article: Hyperpolarized <sup>129</sup>Xe MRI Abnormalities in Dyspneic Patients 3 Months after COVID-19 Pneumonia: Preliminary Results
Hyperpolarized <sup>129</sup>Xe MRI Abnormalities in Dyspneic Patients 3 Months after COVID-19 Pneumonia: Preliminary Results Open
Background SARS-CoV-2 targets angiotensin-converting enzyme 2-expressing cells in the respiratory tract. There are reports of breathlessness in patients many months after infection. Purpose To determine whether hyperpolarized xenon 129 MRI…
View article: Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype
Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype Open
Idiopathic pulmonary fibrosis (IPF) is the most severe form of chronic lung fibrosis. Circulating monocytes have been implicated in immune pathology in IPF but their phenotype is unknown. In this work, we determined the immune phenotype of…
View article: Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience
Successful awake proning is associated with improved clinical outcomes in patients with COVID-19: single-centre high-dependency unit experience Open
The SARS-CoV-2 can lead to severe illness with COVID-19. Outcomes of patients requiring mechanical ventilation are poor. Awake proning in COVID-19 improves oxygenation, but on data clinical outcomes is limited. This single-centre retrospec…