Eric H. Jensen
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A Review of Resection and Surgical Ablation for Primary and Secondary Liver Cancers Open
The surgical management of primary and secondary liver tumors is constantly evolving. Patient selection, particularly with regard to determining resectability, is vital to the success of programs directed toward invasive treatments of live…
Feasibility of laparoscopic microwave ablation of caudate tumors: a case series Open
Microwave ablation of liver tumors allows preservation of liver parenchyma with good oncologic outcomes. However, ablation of tumors in the caudate lobe is particularly challenging. Adjacent critical anatomy, particularly the biliary hilum…
Omission of Axillary Lymph Node Dissection for Breast Cancer Patients with Three or More Positive Sentinel Lymph Nodes Open
Purpose The ACOSOG Z0011 (Z11) trial assessed the benefit of axillary dissection (ALND) for breast cancer patients with sentinel lymph node (SLN) metastases; however, Z11 excluded patients with ≥ 3 positive SLNs. We analyzed trends in ALND…
428 Development of an Oncolytic Adenovirus to Treat Metastatic Colorectal Cancer Open
OBJECTIVES/GOALS: Colorectal cancer (CRC) is a leading cause of cancer mortality, and many patients will develop metastatic disease at some point during their treatment course. Conventional therapies such as surgery, chemotherapy, and radi…
View article: The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer—novel use of a large administrative database
The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer—novel use of a large administrative database Open
Background Screening options for pancreatic ductal adenocarcinoma (PDAC) are limited. New-onset type 2 diabetes (NoD) is associated with subsequent diagnosis of PDAC in observational studies and may afford an opportunity for PDAC screening…
View article: Chemotherapy refusal and subsequent survival in older women with high genomic risk estrogen-receptor positive breast cancer
Chemotherapy refusal and subsequent survival in older women with high genomic risk estrogen-receptor positive breast cancer Open
Background: Patients with estrogen receptor (ER)-positive, HER2-negative breast cancer (BC) and high-risk 21-gene recurrence score (RS) results benefit from chemotherapy. We evaluated chemotherapy refusal and survival in older women with h…
The Addition of Chemoradiation to Adjuvant Chemotherapy is Associated With Improved Survival Following Upfront Surgical Resection for Pancreatic Cancer With Nodal Metastases Open
Background It is unclear whether the addition of chemoradiation (CRT) to adjuvant chemotherapy (CT) following upfront resection of pancreatic ductal adenocarcinoma (PDAC) provides any benefit. While some studies have suggested a benefit to…
Surgical microwave ablation for multifocal non-resectable liver metastases: a single institution experience treating five or more liver lesions Open
Thermal ablation can provide acceptable DFS and OS, even with high volume metastatic colorectal cancers. Future efforts should be focused on defining selection criteria for those most likely to benefit from this aggressive approach.
Role of biliary stent and neoadjuvant chemotherapy in the pancreatic tumor microbiome Open
Background Intra-tumor microbiota have been implicated in pancreatic ductal adenocarcinoma (PDAC) development, treatment response and post-treatment survivorship. Moreover, therapeutic interventions targeting microbiota may improve the res…
Has the pandemic changed public attitudes about science Open
Drawing on survey evidence from several western countries, Eric Allen Jensen, Aaron M. Jensen, Axel Pfleger, Eric B. Kennedy and Ethan Greenwood find that COVID-19 has coincided with a general rise in public trust in science and scientists…
Surgeon decision‐making for management of positive sentinel lymph nodes in the post‐Multicenter Selective Lymphadenectomy Trial II era: A survey study Open
Background and Objectives Completion lymph node dissection (CLND) did not improve melanoma‐specific survival for patients with sentinel lymph node (SLN)‐positive melanoma in the second Multicenter Selective Lymphadenectomy Trial (MSLT‐II).…
Adjuvant chemotherapy for intrahepatic cholangiocarcinoma: approaching clinical practice consensus? Open
Adjuvant chemotherapy use in ICC has increased. More LN positive or patients with T3/T4 tumors are receiving chemotherapy, which may explain the improvement in overall survival.
Genomic expression assay testing among American Indian and Alaska Native women with breast cancer Open
Background Breast cancer is one of the most common causes of cancer mortality for all women, including American Indian and Alaska Native (AI/AN) women. The use of the 21‐gene recurrence score (RS) appears to be predictive of the benefit of…
Systemic therapy without radiation may be appropriate as neoadjuvant therapy for localized pancreas cancer Open
A short course of neoadjuvant chemotherapy without chemoradiation may improve patient selection prior to surgical resection for pancreas cancer. Further, local disease progression did not limit surgical resection in this small series.
Successful endoscopic management of Bouvaret syndrome using laser lithotripsy Open
A 64-year-old white woman, with a remote history of cervical cancer, for which she underwent hysterectomy, and diverticulosis with a colovaginal fistula in the distal sigmoid colon, presented with passage of a grape-sized stone per vagina.…
Incidence and predictors of incisional hernia after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy Open
Background and objectives: The incidence of incisional hernia (IH) after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is largely unknown. Methods: We conducted a retrospective study to identify patients …
Current survival and treatment trends for surgically resected intrahepatic cholangiocarcinoma in the United States Open
After analyzing the treatment and outcomes of resectable ICC, we concluded: (I) LN evaluation at the time of surgical resection remains inadequate; (II) utilization of chemotherapy has increased over time; (III) the lack of LAD likely resu…
Reply to Elderly patients diagnosed with hepatopancreatobiliary malignancies: A challenge beyond resection Open
We appreciate the interest that Lamarca et al have in our recent article1 regarding the comparison of survival outcomes among elderly patients (those aged >65 years) diagnosed with early-stage pancreatic adenocarcinoma. The survival rates …
421. Evaluating the Efficacy of Combination Cancer Treatment: Oncolytic Adenovirus and 5FU Chemotherapy Open
Previous studies have shown that Interferon(IFN)-based chemoradiation therapy can improve survival after resection of pancreas cancer. However, its clinical utility to this point has been limited due to the severe toxicity related to its u…
Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5-<i>f</i>]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans Open
Pancreatic cancer is the fourth leading cause of cancer death in the U.S. Once diagnosed, prognosis is poor with a 5-year survival rate of less than 5%. Exposure to carcinogenic heterocyclic amines (HCAs) derived from cooked meat has been …