Emily Howe
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View article: Forest restoration can bolster salmon population persistence under climate change
Forest restoration can bolster salmon population persistence under climate change Open
View article: Hemispheric interaction in simple reaction time as a function of handedness
Hemispheric interaction in simple reaction time as a function of handedness Open
Efficiency of hemispheric interactions in simple reaction time as a function of hand preference was investigated. Research suggests that left-handed individuals have more efficient hemispheric interactions. This is possibly due to their ne…
View article: Forest gap effects on snow storage in the transitional climate of the Eastern Cascade Range, Washington, United States
Forest gap effects on snow storage in the transitional climate of the Eastern Cascade Range, Washington, United States Open
Forest thinning and gap creation are being implemented across the western United States of America (USA) to reduce wildfire and forest mortality risk as the climate warms. The Eastern Cascades in Washington, USA, is in a transitional zone …
View article: Table S1 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Table S1 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
Clinicopathologic Features of EGFR-Mutant and ALK-Positive Patients Included in PD-L1 Expression Analysis
View article: Figure S4 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Figure S4 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
Quantitative image-based CD8+ TILs in baseline specimens of EGFR-mutant versus KRAS-mutant patients.
View article: Figure S3 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Figure S3 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
Immunohistochemical Analysis of CD8+ Tumor Infiltrating Lymphocytes. Representative images of CD8 scoring: 0 (A), 1+ (B), 2+ (C), and 3+ (D).
View article: Supplemental Figure Legends from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Supplemental Figure Legends from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
Supplemental Figure Legends
View article: Data from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Data from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
Purpose: PD-1 inhibitors are established agents in the management of non–small cell lung cancer (NSCLC); however, only a subset of patients derives clinical benefit. To determine the activity of PD-1/PD-L1 inhibitors within clinical…
View article: Supplemental Figure Legends from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Supplemental Figure Legends from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
Supplemental Figure Legends
View article: Data from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Data from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
Purpose: PD-1 inhibitors are established agents in the management of non–small cell lung cancer (NSCLC); however, only a subset of patients derives clinical benefit. To determine the activity of PD-1/PD-L1 inhibitors within clinical…
View article: Figure S4 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Figure S4 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
Quantitative image-based CD8+ TILs in baseline specimens of EGFR-mutant versus KRAS-mutant patients.
View article: Figure S1 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Figure S1 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
PD-L1 expression in FFPE samples with anti-PD-L1 antibody (clone E1L3N): A) Positive control (HDLM2 cell line with known PD-L1 expression). B) Negative control (PC3 cell line).
View article: Figure S1 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Figure S1 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
PD-L1 expression in FFPE samples with anti-PD-L1 antibody (clone E1L3N): A) Positive control (HDLM2 cell line with known PD-L1 expression). B) Negative control (PC3 cell line).
View article: Figure S5 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Figure S5 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
A-C): Images of autopsy specimens from an ALK-positive NSCLC patient, demonstrating heterogeneous expression of PD-L1 in multiple sections examined (Diffuse PD-L1 expression in A-B and focal PD-L1 expression in C).
View article: Figure S2 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Figure S2 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
PD-L1 Immunohistochemical Analysis. Representative images of negative PD-L1 expression (A), {greater than or equal to}1%, <5% PD-L1 expression (B), {greater than or equal to}5%, <50% PD-L1 expression (C) and {greater than or equal to}50% P…
View article: Figure S5 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Figure S5 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
A-C): Images of autopsy specimens from an ALK-positive NSCLC patient, demonstrating heterogeneous expression of PD-L1 in multiple sections examined (Diffuse PD-L1 expression in A-B and focal PD-L1 expression in C).
View article: Figure S3 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Figure S3 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
Immunohistochemical Analysis of CD8+ Tumor Infiltrating Lymphocytes. Representative images of CD8 scoring: 0 (A), 1+ (B), 2+ (C), and 3+ (D).
View article: Figure S2 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Figure S2 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
PD-L1 Immunohistochemical Analysis. Representative images of negative PD-L1 expression (A), {greater than or equal to}1%, <5% PD-L1 expression (B), {greater than or equal to}5%, <50% PD-L1 expression (C) and {greater than or equal to}50% P…
View article: Table S1 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis
Table S1 from <i>EGFR</i> Mutations and <i>ALK</i> Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis Open
Clinicopathologic Features of EGFR-Mutant and ALK-Positive Patients Included in PD-L1 Expression Analysis
View article: Eastern Cascades Forest-Snow Observations 2019-2021
Eastern Cascades Forest-Snow Observations 2019-2021 Open
View article: Peer Review #2 of "Leveraging the potential of nature to meet net zero greenhouse gas emissions in Washington State (v0.1)"
Peer Review #2 of "Leveraging the potential of nature to meet net zero greenhouse gas emissions in Washington State (v0.1)" Open
The State of
View article: Leveraging the potential of nature to meet net zero greenhouse gas emissions in Washington State
Leveraging the potential of nature to meet net zero greenhouse gas emissions in Washington State Open
The State of Washington, USA, has set a goal to reach net zero greenhouse gas emissions by 2050, the year around which the Intergovernmental Panel on Climate Change (IPCC) recommended we must limit global warming to 1.5 °C above that of pr…
View article: Peer Review #2 of "Leveraging the potential of nature to meet net zero greenhouse gas emissions in Washington State (v0.2)"
Peer Review #2 of "Leveraging the potential of nature to meet net zero greenhouse gas emissions in Washington State (v0.2)" Open
The State of
View article: On the human appropriation of wetland primary production
On the human appropriation of wetland primary production Open
Humans are changing the Earth's surface at an accelerating pace, with significant consequences for ecosystems and their biodiversity. Landscape transformation has far-reaching implications including reduced net primary production (NPP) ava…
View article: Prioritizing conservation actions in urbanizing landscapes
Prioritizing conservation actions in urbanizing landscapes Open
View article: Vignette 7: Stormwater Effluent Exerts a Key Pressure on the Salish Sea
Vignette 7: Stormwater Effluent Exerts a Key Pressure on the Salish Sea Open
One of the primary terrestrial pressures on the Salish Sea estuarine and marine environment is urban stormwater runoff. When rainfall runs across hard, impervious surfaces, rather than soaking into the soil, it picks up and delivers toxic …
View article: Impacts of stormwater on coastal ecosystems: the need to match the scales of management objectives and solutions
Impacts of stormwater on coastal ecosystems: the need to match the scales of management objectives and solutions Open
Despite their limited area relative to the global ocean, coastal zones—the regions where land meets the sea—play a disproportionately important role in generating ecosystem services. However, coastal ecosystems are under increasing pressur…
View article: Food Web Fuel Differs Across Habitats and Seasons of a Tidal Freshwater Estuary
Food Web Fuel Differs Across Habitats and Seasons of a Tidal Freshwater Estuary Open
Estuarine food webs are fueled by multiple different primary producers. However, identifying the relative importance of each producer to consumers is difficult, particularly for fishes that utilize multiple food sources due to both their m…
View article: An integrated environmental and human systems modeling framework for Puget Sound restoration planning
An integrated environmental and human systems modeling framework for Puget Sound restoration planning Open
Local, state, federal, tribal and private stakeholders have committed significant resources to restoring Puget Sound’s terrestrial-marine ecosystem. Though jurisdictional issues have promoted a fragmented approach to restoration planning, …
View article: Shoreline armoring removal: assessment of restoration effectiveness in the Salish Sea
Shoreline armoring removal: assessment of restoration effectiveness in the Salish Sea Open
Shoreline armoring removal is becoming a common restoration technique in the nearshore of the Salish Sea, yet we lack a comprehensive understanding of the ecological benefits obtained, and how such an understanding could be used to inform …