Emily MacLean
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View article: Drug-resistant tuberculosis: a priority pathogen for enhanced public health research and practice
Drug-resistant tuberculosis: a priority pathogen for enhanced public health research and practice Open
SUMMARY Drug-resistant tuberculosis (DR-TB) causes substantial morbidity and mortality and has hindered progress toward TB elimination. This slowed progress toward the WHO End TB Strategy’s targets was exacerbated by lower TB detection dur…
View article: Diagnostic Accuracy of the STANDARD F TB-Feron FIA Assay for Tuberculosis Infection in Vietnam: A Cross-Sectional Study
Diagnostic Accuracy of the STANDARD F TB-Feron FIA Assay for Tuberculosis Infection in Vietnam: A Cross-Sectional Study Open
Background Tuberculosis (TB) infection is a driver of the global TB epidemic. Accurate, affordable, and simpler diagnostics are crucial for identifying people for preventive therapy. We evaluated the diagnostic performance of the STANDARD …
View article: Mettl3 is required for germline function during Drosophila spermatogenesis
Mettl3 is required for germline function during Drosophila spermatogenesis Open
The m6A modification is responsible for regulating several aspects of RNA metabolism. The enzyme that catalyzes this modification Mettl3, is highly conserved and required for numerous biological processes such as spermatogenesis. Here we e…
View article: Long-term Outcomes Among People With Multidrug-Resistant Tuberculosis in Vietnam: A Prospective Cohort Study
Long-term Outcomes Among People With Multidrug-Resistant Tuberculosis in Vietnam: A Prospective Cohort Study Open
Background Existing rates of death and recurrent tuberculosis (TB) among people treated for rifampicin- or multidrug-resistant tuberculosis (RR/MDR-TB) are likely underestimates. We determined long-term disease outcomes among a cohort of p…
View article: Fighting tuberculosis hand in hand: A call to engage communities affected by TB as essential partners in research
Fighting tuberculosis hand in hand: A call to engage communities affected by TB as essential partners in research Open
Tuberculosis (TB) is an infectious disease closely intertwined with stigma, discrimination, and the social determinants of health. Communities of people affected by TB are experts in their care pathways, but the TB field continues to fall …
View article: Host blood protein biomarkers to screen for tuberculosis disease: a systematic review and meta-analysis
Host blood protein biomarkers to screen for tuberculosis disease: a systematic review and meta-analysis Open
Non-sputum tests are needed to improve tuberculosis (TB) diagnosis and close the diagnostic gap. The World Health Organization’s target product profile (TPP) for point-of-care (POC) screening tests requires a minimum sensitivity of 90% and…
View article: Study protocol: diagnostic accuracy study comparing Cy-Tb and STANDARD F TB-Feron FIA tests for tuberculosis infection diagnosis in Vietnam
Study protocol: diagnostic accuracy study comparing Cy-Tb and STANDARD F TB-Feron FIA tests for tuberculosis infection diagnosis in Vietnam Open
Introduction The large reservoir of tuberculosis (TB) infections is one of the main reasons for the persistent incidence of TB. Accurate diagnostic tests are crucial to correctly identify and treat people with TB infection, which is vital …
View article: Host blood protein biomarkers to screen for Tuberculosis disease: a systematic review and meta-analysis
Host blood protein biomarkers to screen for Tuberculosis disease: a systematic review and meta-analysis Open
Introduction Non-sputum tests are needed to improve TB diagnosis and close the diagnostic gap. The World Health Organization target product profile (TPP) for point-of-care (POC) screening tests requires minimum sensitivity 90% and specific…
View article: Subclinical tuberculosis: a meta-analysis of prevalence and scoping review of definitions, prevalence and clinical characteristics
Subclinical tuberculosis: a meta-analysis of prevalence and scoping review of definitions, prevalence and clinical characteristics Open
Background: This scoping review aimed to characterise definitions used to describe subclinical tuberculosis (TB), estimate the prevalence in different populations and describe the clinical characteristics and treatment outcomes in the scie…
View article: Thinking beyond diagnostic accuracy to evaluate tuberculosis screening tests
Thinking beyond diagnostic accuracy to evaluate tuberculosis screening tests Open
Tuberculosis is a leading cause of morbidity and mortality among people living with HIV.1WHOGlobal tuberculosis report 2023.https://www.who.int/publications/i/item/9789240083851Date: 2023Date accessed: February 12, 2024Google Scholar Diagn…
View article: Target product profiles: tests for tuberculosis treatment monitoring and optimization
Target product profiles: tests for tuberculosis treatment monitoring and optimization Open
The World Health Organization has developed target product profiles containing minimum and optimum targets for key characteristics for tests for tuberculosis treatment monitoring and optimization. Tuberculosis treatment optimization refers…
View article: Accuracy of package inserts of SARS-CoV-2 rapid antigen tests: a secondary analysis of manufacturer versus systematic review data
Accuracy of package inserts of SARS-CoV-2 rapid antigen tests: a secondary analysis of manufacturer versus systematic review data Open
None.
View article: Integrating tuberculosis and COVID-19 molecular testing in Lima, Peru: a cross-sectional, diagnostic accuracy study
Integrating tuberculosis and COVID-19 molecular testing in Lima, Peru: a cross-sectional, diagnostic accuracy study Open
For the Spanish translation of the abstract see Supplementary Materials section.
View article: Updating the WHO target product profile for next-generation Mycobacterium tuberculosis drug susceptibility testing at peripheral centres
Updating the WHO target product profile for next-generation Mycobacterium tuberculosis drug susceptibility testing at peripheral centres Open
There were approximately 10 million tuberculosis (TB) cases in 2020, of which 500,000 were drug-resistant. Only one third of drug-resistant TB cases were diagnosed and enrolled on appropriate treatment, an issue partly driven by a lack of …
View article: 317. Use cases for rapid antigen-detecting tests for COVID-19 screening and surveillance: a systematic review
317. Use cases for rapid antigen-detecting tests for COVID-19 screening and surveillance: a systematic review Open
Background Testing remains critical to controlling the COVID-19 pandemic. Antigen-detecting rapid diagnostic tests (Ag-RDTs), which can be used at the point of care, have the potential to increase access to COVID-19 testing, particularly i…
View article: Most common reasons for primary care visits in low- and middle-income countries: A systematic review
Most common reasons for primary care visits in low- and middle-income countries: A systematic review Open
With the Covid-19 pandemic and the introduction of the WHO’s Essential Diagnostics List (EDL), increasing global attention is focused on the crucial role of diagnostics in achieving universal health coverage. To create national EDLs and to…
View article: Use cases for COVID-19 screening and surveillance with rapid antigen-detecting tests: a systematic review
Use cases for COVID-19 screening and surveillance with rapid antigen-detecting tests: a systematic review Open
Introduction Testing is critical to controlling the COVID-19 pandemic. Antigen-detecting rapid diagnostic tests (Ag-RDTs) that can be used at the point of care have the potential to increase access to COVID-19 testing, particularly in sett…
View article: Sandfly Fever Sicilian Virus-Leishmania major co-infection modulates innate inflammatory response favoring myeloid cell infections and skin hyperinflammation
Sandfly Fever Sicilian Virus-Leishmania major co-infection modulates innate inflammatory response favoring myeloid cell infections and skin hyperinflammation Open
Background The leishmaniases are a group of sandfly-transmitted diseases caused by species of the protozoan parasite, Leishmania . With an annual incidence of 1 million cases, 1 billion people living in Leishmania -endemic regions, and nea…
View article: Progress toward Developing Sensitive Non-Sputum-Based Tuberculosis Diagnostic Tests: the Promise of Urine Cell-Free DNA
Progress toward Developing Sensitive Non-Sputum-Based Tuberculosis Diagnostic Tests: the Promise of Urine Cell-Free DNA Open
A highly accurate, non-sputum-based test for tuberculosis (TB) detection is a key priority for the field of TB diagnostics. A recent study in the Journal of Clinical Microbiology by Oreskovic and colleagues (J Clin Microbiol 59:e00074-21, …
View article: Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review
Diagnostic accuracy of point-of-care ultrasound for pulmonary tuberculosis: A systematic review Open
The advent of affordable, portable ultrasound devices has led to increasing interest in the use of point-of-care ultrasound (POCUS) for the detection of pulmonary TB (PTB). We undertook a systematic review of the diagnostic accuracy of POC…
View article: Advances in Molecular Diagnosis of Tuberculosis
Advances in Molecular Diagnosis of Tuberculosis Open
Molecular tests for tuberculosis (TB) have the potential to help reach the three million people with TB who are undiagnosed or not reported each year and to improve the quality of care TB patients receive by providing accurate, quick resul…
View article: Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis
Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis Open
Objective To determine the diagnostic accuracy of serological tests for coronavirus disease-2019 (covid-19). Design Systematic review and meta-analysis. Data sources Medline, bioRxiv, and medRxiv from 1 January to 30 April 2020, using subj…
View article: Adoption and uptake of the lateral flow urine LAM test in countries with high tuberculosis and HIV/AIDS burden: current landscape and barriers
Adoption and uptake of the lateral flow urine LAM test in countries with high tuberculosis and HIV/AIDS burden: current landscape and barriers Open
Background: Since 2015, the World Health Organization (WHO) has recommended a commercially available lateral-flow urine LAM test (Alere-LAM) to assist in the diagnosis of tuberculosis (TB) in severely ill people living with HIV (PLHIV). Th…
View article: Adoption and uptake of the lateral flow urine LAM test in countries with high tuberculosis and HIV/AIDS burden: current landscape and barriers
Adoption and uptake of the lateral flow urine LAM test in countries with high tuberculosis and HIV/AIDS burden: current landscape and barriers Open
Background: Since 2015, the World Health Organization (WHO) has recommended a commercially available lateral-flow urine LAM test (Alere-LAM) to assist in the diagnosis of tuberculosis (TB) in severely ill people living with HIV (PLHIV). Th…