Emily N. Manning
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View article: Effectiveness of Telehealth-Delivered Cognitive Rehabilitation for People with Cognitive Impairment as Part of Long COVID: Results from the CICERO (Cognitive Impairment in Long COVID: Phenotyping and Rehabilitation) Randomised, Controlled, Two-Arm, Parallel-Group, Clinical Trial
Effectiveness of Telehealth-Delivered Cognitive Rehabilitation for People with Cognitive Impairment as Part of Long COVID: Results from the CICERO (Cognitive Impairment in Long COVID: Phenotyping and Rehabilitation) Randomised, Controlled, Two-Arm, Parallel-Group, Clinical Trial Open
View article: Associations of life-course cardiovascular risk factors with late-life cerebral hemodynamics
Associations of life-course cardiovascular risk factors with late-life cerebral hemodynamics Open
While the associations of mid-life cardiovascular risk factors with late-life white matter lesions (WMH) and cognitive decline have been established, the role of cerebral haemodynamics is unclear. We investigated the relation of late-life …
View article: Telehealth-delivered cognitive rehabilitation for people with cognitive impairment as part of the post-COVID syndrome: protocol for a randomised controlled trial as part of the CICERO (Cognitive Impairment in Long COVID: Phenotyping and Rehabilitation) study
Telehealth-delivered cognitive rehabilitation for people with cognitive impairment as part of the post-COVID syndrome: protocol for a randomised controlled trial as part of the CICERO (Cognitive Impairment in Long COVID: Phenotyping and Rehabilitation) study Open
View article: Cerebral blood flow as intermediary between cardiovascular and cerebrovascular health: results from the Insight46 study
Cerebral blood flow as intermediary between cardiovascular and cerebrovascular health: results from the Insight46 study Open
Introduction: Mid-life cardiovascular and late-life structural cerebrovascular pathology play a major role in accelerating cognitive decline in normal aging and dementia. Cerebral blood flow (CBF) may be a critical intermediate biomarker o…
View article: Associations between ASL‐derived cerebrovascular health and cognitive performance: results from the Insight 46 study
Associations between ASL‐derived cerebrovascular health and cognitive performance: results from the Insight 46 study Open
Background Cardiovascular and cerebrovascular pathology may accelerate brain aging and cognitive decline. Structural cerebrovascular imaging biomarkers, such as white matter hyperintensities, reflect mostly irreversible accumulated damage.…
View article: Associations between ASL‐derived cerebrovascular health and cognitive performance: results from the Insight 46 study
Associations between ASL‐derived cerebrovascular health and cognitive performance: results from the Insight 46 study Open
Background Cardiovascular and cerebrovascular pathology may accelerate brain aging and cognitive decline. Structural cerebrovascular imaging biomarkers, such as white matter hyperintensities, reflect mostly irreversible accumulated damage.…
View article: Neuroimaging, clinical and life course correlates of normal-appearing white matter integrity in 70-year-olds
Neuroimaging, clinical and life course correlates of normal-appearing white matter integrity in 70-year-olds Open
We investigate associations between normal-appearing white matter microstructural integrity in cognitively normal ∼70-year-olds and concurrently measured brain health and cognition, demographics, genetics and life course cardiovascular hea…
View article: Predicting Cognitive Decline in Older Adults Using Baseline Metrics of AD Pathologies, Cerebrovascular Disease, and Neurodegeneration
Predicting Cognitive Decline in Older Adults Using Baseline Metrics of AD Pathologies, Cerebrovascular Disease, and Neurodegeneration Open
Lower hippocampal volume was a consistent predictor of clinical conversion to MCI and AD. CSF and brain volume biomarkers were predictive of conversion to AD from MCI, whereas WMH were predictive of conversion to MCI from cognitively norma…
View article: Baseline MRI and CSF measurements in cognitively normal individuals as prognostic markers of progression to mild cognitive impairment
Baseline MRI and CSF measurements in cognitively normal individuals as prognostic markers of progression to mild cognitive impairment Open
Background Alzheimer’s disease is currently one of our greatest socioeconomic challenges. Understanding the ability of biomarkers to predict clinical progression, prior to significant cognitive decline, is critical when considering seconda…
View article: White matter hyperintensity increases are a feature of familial AD and are associated with increased brain atrophy
White matter hyperintensity increases are a feature of familial AD and are associated with increased brain atrophy Open
Background Relatively little is known about how white matter hyperintensity (WMH) changes relate to well‐characterised markers of disease progression such as brain atrophy rates in autosomal dominant familial AD (ADAD). Such analyses may i…
View article: Automated White Matter Hyperintensity Segmentation Using Bayesian Model Selection: Assessment and Correlations with Cognitive Change
Automated White Matter Hyperintensity Segmentation Using Bayesian Model Selection: Assessment and Correlations with Cognitive Change Open
Accurate, automated white matter hyperintensity (WMH) segmentations are needed for large-scale studies to understand contributions of WMH to neurological diseases. We evaluated Bayesian Model Selection (BaMoS), a hierarchical fully-unsuper…
View article: A Comparison of Accelerated and Non-accelerated MRI Scans for Brain Volume and Boundary Shift Integral Measures of Volume Change: Evidence from the ADNI Dataset
A Comparison of Accelerated and Non-accelerated MRI Scans for Brain Volume and Boundary Shift Integral Measures of Volume Change: Evidence from the ADNI Dataset Open
View article: Differential hippocampal shapes in posterior cortical atrophy patients: A comparison with control and typical <scp>AD</scp> subjects
Differential hippocampal shapes in posterior cortical atrophy patients: A comparison with control and typical <span>AD</span> subjects Open
Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by predominant visual deficits and parieto‐occipital atrophy, and is typically associated with Alzheimer's disease (AD) pathology. In AD, assessment of hippocam…
View article: Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia
Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia Open
Abnormal eating behaviors are frequently reported in behavioral variant frontotemporal dementia (bvFTD). The hypothalamus is the regulatory center for feeding and satiety but its involvement in bvFTD has not been fully clarified, partly du…