Emily Powell
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View article: PEPITEM and its tripeptide pharmacophores: Mechanisms of bone regulation and therapeutic potential in health and disease
PEPITEM and its tripeptide pharmacophores: Mechanisms of bone regulation and therapeutic potential in health and disease Open
Current osteoporosis therapies are limited by their inability to fully restore bone homeostasis and significant side effects through long-term use. PEPITEM is an endogenous 14 amino acid osteogenic peptide capable of stimulating osteoblast…
View article: Influence of preoperative blood pressure on postoperative bleeding complications following Mohs micrographic surgery
Influence of preoperative blood pressure on postoperative bleeding complications following Mohs micrographic surgery Open
Hypertensive patients and those on anticoagulation/antiplatelet therapy are not at significantly increased risk of bleeding or other complications following MMS.
View article: Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffness
Phonocardiography based pulse wave velocity system for non-occlusive assessment of arterial stiffness Open
Arterial stiffness is strongly associated with vascular aging and pathology and can be assessed in many ways. Existing devices for measuring central arterial stiffness, such as carotid-femoral pulse wave velocity (PWV), are limited by high…
View article: An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naïve and longitudinal samples throughout neoadjuvant chemotherapy
An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naïve and longitudinal samples throughout neoadjuvant chemotherapy Open
SUMMARY Triple negative breast cancer (TNBC) that fails to respond to neoadjuvant chemotherapy (NACT) can be lethal. Developing effective strategies to eradicate chemoresistant disease requires experimental models that recapitulate the het…
View article: Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss
Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss Open
View article: Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss
Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss Open
The existing suite of therapies for bone diseases largely act to prevent further bone loss but fail to stimulate healthy bone formation and repair. We describe an endogenous osteopeptide (PEPITEM) with anabolic osteogenic activity, regulat…
View article: Spatial disparities in air conditioning ownership in Florida, United States
Spatial disparities in air conditioning ownership in Florida, United States Open
This study emphasizes the critical role of air conditioning (AC) in preventing heat-related illnesses such as heat exhaustion and heatstroke. The challenge of limited geographic coverage and outdated AC availability data hampers effective …
View article: Failure of Nasal Defect Closures Following the Use of Continuous Positive Airway Pressure
Failure of Nasal Defect Closures Following the Use of Continuous Positive Airway Pressure Open
In this paper, we report a case series of three patients who developed nasal tip necrosis following Mohs micrographic surgery (MMS), complicated by the concomitant use of a continuous positive airway pressure (CPAP) machine for sleep apnea.
View article: Demographics of Skin Cancer Knowledge Among Middle and High Schoolers in Texas
Demographics of Skin Cancer Knowledge Among Middle and High Schoolers in Texas Open
Introduction: Adolescents, an age group that can reduce sun exposure early, may benefit from school-based skin cancer education programs. Literature regarding the demographics of melanoma knowledge is sparse. Objectives: This study sought …
View article: Predictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer
Predictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer Open
Patient-derived xenograft (PDX) models of breast cancer are an effective discovery platform and tool for preclinical pharmacologic testing and biomarker identification. We established orthotopic PDX models of triple negative breast cancer …
View article: Spatial disparities in air conditioning ownership in Florida, United States
Spatial disparities in air conditioning ownership in Florida, United States Open
This study emphasizes the critical role of air conditioning (AC) in preventing heat-related illnesses such as heat exhaustion and heatstroke. The challenge of limited geographic coverage and outdated AC availability data hampers effective …
View article: Clinical impact of number of lymph nodes dissected on postoperative survival in node-negative small cell lung cancer
Clinical impact of number of lymph nodes dissected on postoperative survival in node-negative small cell lung cancer Open
Objectives Small cell lung cancer (SCLC) is a lethal histologic subtype of lung cancer. Although the Commission on Cancer recommends pathological examination of at least 10 lymph nodes dissected (LNDs) for resected early-stage non-small ce…
View article: Fifth Annual Summer Research Summit on Health Equity Organized by the Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas 77030, USA on May 17, 2022
Fifth Annual Summer Research Summit on Health Equity Organized by the Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas 77030, USA on May 17, 2022 Open
The fifth annual summer research summit organized by the Center of Excellence (COE) in Health Equity, Training and Research, Baylor College of Medicine (BCM), was held on May 17, 2022. The theme of this year’s summit was ‘Academic-Communit…
View article: Geometry-Based Computational Fluid Dynamic Model for Predicting the Biological Behavior of Bone Tissue Engineering Scaffolds
Geometry-Based Computational Fluid Dynamic Model for Predicting the Biological Behavior of Bone Tissue Engineering Scaffolds Open
The use of biocompatible and biodegradable porous scaffolds produced via additive manufacturing is one of the most common approaches in tissue engineering. The geometric design of tissue engineering scaffolds (e.g., pore size, pore shape, …
View article: Spatial Disparities in Air Conditioning Ownership in Florida, United States
Spatial Disparities in Air Conditioning Ownership in Florida, United States Open
Background Air conditioning usage is the most effective intervention to prevent heat-related illnesses such as heat exhaustion and heatstroke. However, limited geographic coverage and outdated information on air conditioning (AC) availabil…
View article: P63.04 Minimum Number of Lymph Node Dissections for Resectable Early-Stage Small Cell Lung Cancer
P63.04 Minimum Number of Lymph Node Dissections for Resectable Early-Stage Small Cell Lung Cancer Open
View article: P75.06 Survival Benefit From Immunocheckpoint Inhibitors in Stage IV Non-Small Cell Lung Cancer Patients With Brain Metastases
P75.06 Survival Benefit From Immunocheckpoint Inhibitors in Stage IV Non-Small Cell Lung Cancer Patients With Brain Metastases Open
View article: Role of Immunotherapy in Stage IV Large Cell Neuroendocrine Carcinoma of the Lung
Role of Immunotherapy in Stage IV Large Cell Neuroendocrine Carcinoma of the Lung Open
This retrospective study using NCDB suggests that use of immunotherapy may improve survival of LCNEC patients.
View article: Survival benefit from immunocheckpoint inhibitors in stage IV non‐small cell lung cancer patients with brain metastases: A National Cancer Database propensity‐matched analysis
Survival benefit from immunocheckpoint inhibitors in stage IV non‐small cell lung cancer patients with brain metastases: A National Cancer Database propensity‐matched analysis Open
Immunocheckpoint inhibitors (ICIs) have become a standard pharmacological therapy in non‐small cell lung cancer (NSCLC). Because brain metastases (BMs) have historically been listed as exclusion criteria in previous clinical trials involvi…
View article: Prognostic Impact of Single and Multiple Descriptors in Pathologically Staged T3N0M0 NSCLC
Prognostic Impact of Single and Multiple Descriptors in Pathologically Staged T3N0M0 NSCLC Open
View article: Impact of immunotherapy use in patients with stage IV pancreatic carcinoma
Impact of immunotherapy use in patients with stage IV pancreatic carcinoma Open
This retrospective data analysis using a large cancer database suggests that use of IO could improve survival in patients with advanced pancreatic cancer. More studies will be needed in the future to validate these results.
View article: Recent trends in use of adjuvant chemotherapy in elderly stage II– III non-small cell lung cancer
Recent trends in use of adjuvant chemotherapy in elderly stage II– III non-small cell lung cancer Open
This study suggests that use of adjuvant chemotherapy in the elderly population increased primarily in age 70-79. Few patients in the 80+ age group received adjuvant chemotherapy even in recent years.
View article: Brain metastasis as exclusion criteria in extensive-stage small cell lung cancer trials: a trend over decades
Brain metastasis as exclusion criteria in extensive-stage small cell lung cancer trials: a trend over decades Open
Journal of Cancer Metastasis and Treatment is an open access journal, focusing on basic and clinical studies related to cancer cell, cell biology, oncology, radiation therapy and radiology, obstetrics and gynecology, pediatrics, surgery, h…
View article: The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing
The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing Open
View article: Prognostic impact of single and multiple descriptors in pathologically staged T3N0M0 non-small cell lung cancer
Prognostic impact of single and multiple descriptors in pathologically staged T3N0M0 non-small cell lung cancer Open
View article: Abstract 2901: Clonal dynamics and phenotypic evolution during chemoresistance and metastasis revealed by patient-derived xenograft models of triple negative breast cancer
Abstract 2901: Clonal dynamics and phenotypic evolution during chemoresistance and metastasis revealed by patient-derived xenograft models of triple negative breast cancer Open
Half of all triple negative breast cancer (TNBC) patients harbor significant residual cancer burden following standard neoadjuvant chemotherapy treatment, resulting in distant metastasis and death for most of these patients. Intra-tumor he…
View article: Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study
Multiwalled carbon nanotubes for combination therapy: a biodistribution and efficacy pilot study Open
A doxorubicin/metformin carrier for chemotherapy based on oxidized MWCNTs. Efficacy in vitro and in vivo.
View article: High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer Open
View article: BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation Open
Significance Spontaneous overexpression of endogenous IRIS, an alternatively spliced product of the tumor suppressor gene BRCA1 , allows it to function as an oncoprotein that stimulates a potentially lethal outcome, i.e. metastasis of huma…
View article: A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis
A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis Open