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View article: Antidepressant Potential of Species from the Piperaceae Family: A Comprehensive Review of Preclinical Studies
Antidepressant Potential of Species from the Piperaceae Family: A Comprehensive Review of Preclinical Studies Open
The Piperaceae family is recognized for its ethnopharmacological relevance and diversity of secondary metabolites. Several species, such as Piper nigrum, Piper methysticum and Piper longum, have been traditionally used for their effects on…
View article: Orofacial antinociceptive activity of codeine-associated geraniol in mice: a controlled triple-blind study
Orofacial antinociceptive activity of codeine-associated geraniol in mice: a controlled triple-blind study Open
This is a nonclinical, controlled, and triple-blind study to investigate the effects of codeine-associated geraniol on the modulation of orofacial nociception and its potential central nervous system depressing effect in an animal model. T…
View article: Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence
Methyleugenol Has an Antidepressant Effect in a Neuroendocrine Model: In Silico and In Vivo Evidence Open
Major depressive disorder is a severe mood disorder characterized by different emotions and feelings. This study investigated the antidepressant activity of the phenylpropanoid methyleugenol (ME) in adult female mice exposed to a stress mo…
View article: Computational Studies Applied to Linalool and Citronellal DerivativesAgainst Alzheimer's and Parkinson's Disorders: A Review with ExperimentalApproach
Computational Studies Applied to Linalool and Citronellal DerivativesAgainst Alzheimer's and Parkinson's Disorders: A Review with ExperimentalApproach Open
Alzheimer's and Parkinson's are neurodegenerative disorders that affect a great number of people around the world, seriously compromising the quality of life of individuals, due to motor and cognitive damage. In these diseases, pharmacolog…
View article: Evaluation of the antinociceptive effect generated by citronellal monoterpene isomers
Evaluation of the antinociceptive effect generated by citronellal monoterpene isomers Open
Due to the complex nature of pain and the participation of physical, cognitive, psychological and behavioral aspects, pain management has several approaches. The use of medicinal plants in developing countries is quite expressive. Seeking …
View article: Anticonvulsant Activity of Tetrahydrolinalool: Behavioral, Electrophysiological, and Molecular Docking Approaches
Anticonvulsant Activity of Tetrahydrolinalool: Behavioral, Electrophysiological, and Molecular Docking Approaches Open
View article: A 9-aminoacridine derivative induces growth inhibition of Ehrlich ascites carcinoma cells and antinociceptive effect in mice
A 9-aminoacridine derivative induces growth inhibition of Ehrlich ascites carcinoma cells and antinociceptive effect in mice Open
Acridine derivatives have been found with anticancer and antinociceptive activities. Herein, we aimed to evaluate the toxicological, antitumor, and antinociceptive actions of N’-(6-chloro-2-methoxyacridin-9-yl)-2-cyanoacetohydrazide (ACS-A…
View article: Avaliação da citotoxicidade do ácido 3-cumarino carboxílico em eritrócitos humanos
Avaliação da citotoxicidade do ácido 3-cumarino carboxílico em eritrócitos humanos Open
O eritrócito é um tipo celular altamente suscetível peroxidação lipídica e hemólise. Testes in vitro de citotoxicidade são frequentemente usados para rastrear e determinar a toxicidade de vários compostos, principalmente para investigar …
View article: Analgesic-like activity of perillyl acetate
Analgesic-like activity of perillyl acetate Open
Objective: To evaluate the antinociceptive activity of perillyl acetate in mice and in silico simulations. Methods: The vehicle, perillyl acetate (100, 150 and/or 200 mg/ kg, i.p.) , diazepam (2 mg/kg, i.p.) or morphine (6 mg/kg, i.p.) was…
View article: Anticonvulsant Activity of <i>trans</i>‐Anethole in Mice
Anticonvulsant Activity of <i>trans</i>‐Anethole in Mice Open
Epilepsy is a chronic neurological disorder affecting 1‐2% of world population, and one‐third of patients are refractory to pharmacological treatment. This fact has stimulated research for new antiepileptic drugs and natural products have …
View article: Orofacial antinociceptive effects of perillyl alcohol associated with codeine and its possible modes of action
Orofacial antinociceptive effects of perillyl alcohol associated with codeine and its possible modes of action Open
This study evaluated the orofacial antinociceptive effect of (S)-(-)-perillyl alcohol (PA) associated with codeine (C) and investigated the possible molecular anchorage mechanisms of PA. Mice (n = 5 per group) were treated with PA alone an…
View article: Orofacial antinociceptive effects of perillyl alcohol associated with codeine and its possible modes of action
Orofacial antinociceptive effects of perillyl alcohol associated with codeine and its possible modes of action Open
This study evaluated the orofacial antinociceptive effect of (S)-(-)-perillyl alcohol (PA) associated with codeine (C) and investigated the possible molecular anchorage mechanisms of PA. Mice (n = 5 per group) were treated with PA alone an…
View article: Ácido 3,4,5-Trimetoxicinâmico e seu Potencial Terapêutico: Uma Revisão / 3,4,5-Trimethoxycinnamic Acid and Its Therapeutic Potential: A Review
Ácido 3,4,5-Trimetoxicinâmico e seu Potencial Terapêutico: Uma Revisão / 3,4,5-Trimethoxycinnamic Acid and Its Therapeutic Potential: A Review Open
As plantas medicinais tem se constituído como uma das principais fontes na obtenção de novos fármacos e no desenvolvimento de medicamentos. A fitoterapia é praticada na Medicina Tradicional Chinesa há séculos e plantas como a Polygala tenu…
View article: Thiophene-Based Compounds with Potential Anti-Inflammatory Activity
Thiophene-Based Compounds with Potential Anti-Inflammatory Activity Open
Rheumatoid arthritis, arthrosis and gout, among other chronic inflammatory diseases are public health problems and represent major therapeutic challenges. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most prescribed clinical trea…
View article: Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex
Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex Open
Lippia pedunculosa Hayek (EOLp) presents tripanocid and amebicid effects. However essential oil needs to be further studied in experimental models of analgesia and inflammation once the prevalence of pain in the population generates great …
View article: Non-clinical study of the anxiolytic effect of Citrus aurantium L. essential oil in an inclusion complex with 2-hydroxypropyl-ß-cyclodextrin
Non-clinical study of the anxiolytic effect of Citrus aurantium L. essential oil in an inclusion complex with 2-hydroxypropyl-ß-cyclodextrin Open
Anxiety in the world population has increased significantly; the problem has encouraged studies regarding innovative alternatives for treatment. Research with Citrus aurantium L. essential oil (CEO) has revealed positive results with anxio…
View article: Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol
Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol Open
We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i…
View article: Involvement of GABA<sub>A</sub> Receptors in the Anxiolytic‐Like Effect of Hydroxycitronellal
Involvement of GABA<sub>A</sub> Receptors in the Anxiolytic‐Like Effect of Hydroxycitronellal Open
Hydroxycitronellal (HC) is a monoterpene present in essential oils of aromatic plants of different species, obtained from semisynthesis of citronellal, and is widely used as a fragrance in cosmetics. The objective of this work was to evalu…
View article: RMD86, a thiophene derivative, promotes antinociceptive and antipyretic activities in mice
RMD86, a thiophene derivative, promotes antinociceptive and antipyretic activities in mice Open
View article: Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review
Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review Open
The studies revealed that through the advancement of more robust computational techniques that complement the experimental studies, they may allow some notes on the identification of a new candidate molecule for therapeutic use.
View article: Psychopharmacological effects of riparin III from Aniba riparia (Nees) Mez. (Lauraceae) supported by metabolic approach and multivariate data analysis
Psychopharmacological effects of riparin III from Aniba riparia (Nees) Mez. (Lauraceae) supported by metabolic approach and multivariate data analysis Open
View article: Anxiolytic and antinociceptive-like effects of cinnamic alcohol by possible GABAergic pathway modulation: In vivo and in silico studies
Anxiolytic and antinociceptive-like effects of cinnamic alcohol by possible GABAergic pathway modulation: In vivo and in silico studies Open
View article: WARIFTEINE THERAPEUTIC TREATMENT REDUCED LEUKOCYTE RECRUITMENT AND ANXIETY-LIKE RESPONSE IN OVALBUMIN-INDUCED ALLERGIC PULMONARY INFLAMMATION / TRATAMENTO TERAPÊUTICO COM WARIFTEÍNA REDUZ RECRUTAMENTO DE LEUCÓCITOS E RESPOSTA SEMELHANTE Á ANSIEDADE NA INFLAMAÇÃO PULMONAR ALÉRGICA INDUZIDA POR OVALBUMINA
WARIFTEINE THERAPEUTIC TREATMENT REDUCED LEUKOCYTE RECRUITMENT AND ANXIETY-LIKE RESPONSE IN OVALBUMIN-INDUCED ALLERGIC PULMONARY INFLAMMATION / TRATAMENTO TERAPÊUTICO COM WARIFTEÍNA REDUZ RECRUTAMENTO DE LEUCÓCITOS E RESPOSTA SEMELHANTE Á ANSIEDADE NA INFLAMAÇÃO PULMONAR ALÉRGICA INDUZIDA POR OVALBUMINA Open
Pulmonary inflammation plays a fundamental role in the pathophysiology of allergic asthma, which is characterized by lower airway obstruction, bronchial hyperresponsiveness, tissue remodeling, recruitment of inflammatory cells, with a pred…
View article: Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol
Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol Open
We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i…
View article: Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy
Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy Open
Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may …
View article: Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development
Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development Open
Depression is a health problem that compromises the quality of life of the world′s population. It has different levels of severity and a symptomatic profile that affects social life and performance in work activities, as well as a high num…
View article: Trypanocidal Mechanism of Action and in silico Studies of p-Coumaric Acid Derivatives
Trypanocidal Mechanism of Action and in silico Studies of p-Coumaric Acid Derivatives Open
Trypanosoma species are responsible for chronic and systemic infections in millions of people around the world, compromising life quality, and family and government budgets. This group of diseases is classified as neglected and causes thou…
View article: Efeito do sombreamento na qualidade da bebida de café conilon cultivado em sistemas consorciados
Efeito do sombreamento na qualidade da bebida de café conilon cultivado em sistemas consorciados Open
The objective of this work was to analyze the physical and sensorial quality of Conilon coffee beans grown in different shading systems. The management systems evaluated were: unshaded coffee (monoculture coffee in full sun) - PS; coffee i…
View article: Design, synthesis and pharmacological evaluation of CVIB, a codrug of carvacrol and ibuprofen as a novel anti-inflammatory agent
Design, synthesis and pharmacological evaluation of CVIB, a codrug of carvacrol and ibuprofen as a novel anti-inflammatory agent Open
View article: NFBTA: A Potent Cytotoxic Agent against Glioblastoma
NFBTA: A Potent Cytotoxic Agent against Glioblastoma Open
Piplartine (PPL), also known as piperlongumine, is a biologically active alkaloid extracted from the Piper genus which has been found to have highly effective anticancer activity against several tumor cell lines. This study investigates in…