Emily Serbinowski
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View article: Hepatobiliary malignancies have distinct peripheral myeloid-derived suppressor cell signatures and tumor myeloid cell profiles
Hepatobiliary malignancies have distinct peripheral myeloid-derived suppressor cell signatures and tumor myeloid cell profiles Open
Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that are increased in patients with numerous malignancies including viral-derived hepatocellular carcinoma (HCC). Here, we report an elevation of MDSCs in the peripheral …
View article: Cholangiocarcinoma presents a distinct myeloid-derived suppressor cell signature compared to other hepatobiliary cancers
Cholangiocarcinoma presents a distinct myeloid-derived suppressor cell signature compared to other hepatobiliary cancers Open
Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that are increased in patients with numerous malignancies including viral-derived hepatocellular carcinoma (HCC). Here, we report an elevation of MDSC in other hepatobili…
View article: IMMU-70. GLOBAL IMMUNE FINGERPRINTING IN GLIOBLASTOMA REVEALS IMMUNE-SUPPRESSION SIGNATURES ASSOCIATED WITH PROGNOSIS
IMMU-70. GLOBAL IMMUNE FINGERPRINTING IN GLIOBLASTOMA REVEALS IMMUNE-SUPPRESSION SIGNATURES ASSOCIATED WITH PROGNOSIS Open
Therapeutic resistance in glioblastoma (GBM) is linked to cancer stem cells and signaling pathway alterations, but the role of local and systemic immune suppression during disease progression is less understood. To determine how the immune…
View article: TMIC-51. DEXAMETHASONE DRIVES MYELOID-DERIVED SUPPRESSOR CELL ACCUMULATION IN GLIOBLASTOMA IN A SEX-SPECIFIC MANNER
TMIC-51. DEXAMETHASONE DRIVES MYELOID-DERIVED SUPPRESSOR CELL ACCUMULATION IN GLIOBLASTOMA IN A SEX-SPECIFIC MANNER Open
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive cells consisting of monocytic (M-MDSC) and granulocytic (G-MDSC) subsets that accumulate in tumors, where they constrain anti-tumor immunity. High…
View article: Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis
Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis Open
Glioblastoma (GBM) remains uniformly lethal, and despite a large accumulation of immune cells in the microenvironment, there is limited antitumor immune response. To overcome these challenges, a comprehensive understanding of GBM systemic …
View article: Global immune fingerprinting in glioblastoma reveals immune-suppression signatures associated with prognosis
Global immune fingerprinting in glioblastoma reveals immune-suppression signatures associated with prognosis Open
/Summary Glioblastoma (GBM) remains uniformly lethal, and, despite a large accumulation of immune cells in the microenvironment, there is limited anti-tumor immune response, even with newly developed immune checkpoint therapies. To overcom…
View article: Development of a Cx46 targeting strategy for cancer stem cells
Development of a Cx46 targeting strategy for cancer stem cells Open
Summary Gap junction-mediated cell-cell communication enables tumor cells to synchronize the execution of complex processes. Despite the connexin family of gap junction proteins being considered tumor suppressors, we previously found that …
View article: Layer-by-Layer Printing of Alginate for Cancer Cell Migration Assays
Layer-by-Layer Printing of Alginate for Cancer Cell Migration Assays Open
Rapid assessment of the invasion potential of various cancers in three-dimensional (3D) cell culture via layer-by-layer printing of cells encapsulated in hydrogels has been studied. Microarray bioprinting technology on microwell chips has …
View article: High-Throughput Assessment of Developmental Stages of NSCs via Promoter-Reporter Assay System Using Recombinant Lentiviruses
High-Throughput Assessment of Developmental Stages of NSCs via Promoter-Reporter Assay System Using Recombinant Lentiviruses Open
Many drugs and chemicals currently available have not been fully evaluated for their toxic effects on the developing brain. Expensive and low-throughput in vivo studies are still being used to evaluate developmental neurotoxicity (DNT). Th…