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View article: Extending the Baveno VII definition of recompensation to autoimmune hepatitis: Considerations regarding treatment timing and response criteria
Extending the Baveno VII definition of recompensation to autoimmune hepatitis: Considerations regarding treatment timing and response criteria Open
View article: Clinical Features of Portal Hypertension and Their Prognostic Implications in Patients With Autoimmune Hepatitis
Clinical Features of Portal Hypertension and Their Prognostic Implications in Patients With Autoimmune Hepatitis Open
Background and Aims Autoimmune hepatitis (AIH) may progress to advanced chronic liver disease (ACLD) with clinically significant portal hypertension (CSPH). In this study, we evaluated the prevalence of different clinical CSPH features and…
View article: 24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting T<sub>H</sub>17 pathogenicity and transdifferentiation
24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting T<sub>H</sub>17 pathogenicity and transdifferentiation Open
Background 24-Nor-ursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid for treating immune-mediated cholestatic liver diseases, such as primary sclerosing cholangitis (PSC). Objective Since PSC strongly associates with T helper-…
View article: Elevated Hepatic Copper Content in Porto‐Sinusoidal Vascular Disorder (<scp>PSVD</scp>): <i>Leading Down a Wrong Track</i>
Elevated Hepatic Copper Content in Porto‐Sinusoidal Vascular Disorder (<span>PSVD</span>): <i>Leading Down a Wrong Track</i> Open
Background and Aims Porto‐sinusoidal vascular disorder (PSVD) is a rare vascular liver disorder characterised by specific histological findings in the absence of cirrhosis, which is poorly understood in terms of pathophysiology. While elev…
View article: Presence of cholestasis and its impact on survival in SARS-CoV-2 associated acute respiratory distress syndrome
Presence of cholestasis and its impact on survival in SARS-CoV-2 associated acute respiratory distress syndrome Open
View article: Disease severity prognostication in primary sclerosing cholangitis: a validation of the Anali scores and comparison with the potential functional stricture
Disease severity prognostication in primary sclerosing cholangitis: a validation of the Anali scores and comparison with the potential functional stricture Open
View article: Editorial: Recompensation in PBC is good. But is it good enough? Authors' reply
Editorial: Recompensation in PBC is good. But is it good enough? Authors' reply Open
LINKED CONTENT This article is linked to Hofer et al papers. To view these articles, visit https://doi.org/10.1111/apt.17908 and https://doi.org/10.1111/apt.17924
View article: Primär sklerosierende Cholangitis – Diagnose und Therapie 2024
Primär sklerosierende Cholangitis – Diagnose und Therapie 2024 Open
View article: Evaluation of potential hepatic recompensation criteria in patients with <scp>PBC</scp> and decompensated cirrhosis
Evaluation of potential hepatic recompensation criteria in patients with <span>PBC</span> and decompensated cirrhosis Open
Summary Background Aetiological therapy improves liver function and may enable hepatic recompensation in decompensated cirrhosis. Aims We explored the potential for recompensation in patients with decompensated primary biliary cholangitis …
View article: Short-term intake of fiber-rich oat bran but not spelt bran flake mix lowers bacterial endotoxin levels and improves health parameters in healthy, normal weight, young to middle-aged women
Short-term intake of fiber-rich oat bran but not spelt bran flake mix lowers bacterial endotoxin levels and improves health parameters in healthy, normal weight, young to middle-aged women Open
Diets low in dietary fiber have been associated with higher risks for non-communicable chronic diseases. We assessed in a single-blinded cross-over designed study if oat bran and spelt bran rich flake mixes, respectively, are suitable to i…
View article: Antibiotics attenuate diet-induced nonalcoholic fatty liver disease without altering intestinal barrier dysfunction
Antibiotics attenuate diet-induced nonalcoholic fatty liver disease without altering intestinal barrier dysfunction Open
To date the role of the alterations of intestinal microbiota in the development of intestinal barrier dysfunction in settings of nonalcoholic fatty liver disease (NAFLD) has not been fully understood. Here, we assessed the effect of antibi…
View article: Incidence and predictors of hepatocellular carcinoma in patients with autoimmune hepatitis
Incidence and predictors of hepatocellular carcinoma in patients with autoimmune hepatitis Open
View article: Diagnosis of functional strictures in patients with primary sclerosing cholangitis using hepatobiliary contrast-enhanced MRI: a proof-of-concept study
Diagnosis of functional strictures in patients with primary sclerosing cholangitis using hepatobiliary contrast-enhanced MRI: a proof-of-concept study Open
Objectives PSC strictures are routinely diagnosed on T2-MRCP as dominant- (DS) or high-grade stricture (HGS). However, high inter-observer variability limits their utility. We introduce the “potential functional stricture” (PFS) on T1-weig…
View article: A Xanthohumol-Rich Hop Extract Diminishes Endotoxin-Induced Activation of TLR4 Signaling in Human Peripheral Blood Mononuclear Cells: A Study in Healthy Women
A Xanthohumol-Rich Hop Extract Diminishes Endotoxin-Induced Activation of TLR4 Signaling in Human Peripheral Blood Mononuclear Cells: A Study in Healthy Women Open
Infections with Gram-negative bacteria are still among the leading causes of infection-related deaths. Several studies suggest that the chalcone xanthohumol (XN) found in hop (Humulus lupulus) possesses anti-inflammatory effects. In a sing…
View article: In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay
In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay Open
View article: Oral intake of xanthohumol attenuates lipoteichoic acid-induced inflammatory response in human PBMCs
Oral intake of xanthohumol attenuates lipoteichoic acid-induced inflammatory response in human PBMCs Open
View article: Progressive cholestasis and associated sclerosing cholangitis are frequent complications of COVID‐19 in patients with chronic liver disease
Progressive cholestasis and associated sclerosing cholangitis are frequent complications of COVID‐19 in patients with chronic liver disease Open
Background and Aims Cholestasis is associated with disease severity and worse outcome in COVID‐19. Cases of secondary sclerosing cholangitis (SSC) after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection have been descr…
View article: 24-Nor-ursodeoxycholic acid counteracts T<sub>H</sub>17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating T<sub>H</sub>17 cells
24-Nor-ursodeoxycholic acid counteracts T<sub>H</sub>17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating T<sub>H</sub>17 cells Open
Objective 24-Nor-ursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid for treating primary sclerosing cholangitis (PSC), an immune-mediated cholestatic liver disease. Since PSC strongly associates with inflammatory bowel disease…
View article: Systematic review of response criteria and endpoints in autoimmune hepatitis by the International Autoimmune Hepatitis Group
Systematic review of response criteria and endpoints in autoimmune hepatitis by the International Autoimmune Hepatitis Group Open
View article: Distinct prognostic value of different portal hypertension-associated features in patients with primary biliary cholangitis
Distinct prognostic value of different portal hypertension-associated features in patients with primary biliary cholangitis Open
Background Primary biliary cholangitis (PBC) may progress to cirrhosis and clinically significant portal hypertension (CSPH). This study assesses different features of CSPH and their distinct prognostic impact regarding decompensation and …
View article: Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression
Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD Progression Open
Mouse models of non-alcoholic fatty liver disease (NAFLD) are required to define therapeutic targets, but detailed time-resolved studies to establish a sequence of events are lacking. Here, we fed male C57Bl/6N mice a Western or standard d…
View article: Hepatocyte‐specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin‐like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice
Hepatocyte‐specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin‐like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice Open
Background and Aims Increased fatty acid (FA) flux from adipose tissue to the liver contributes to the development of NAFLD. Because free FAs are key lipotoxic triggers accelerating disease progression, inhibiting adipose triglyceride lipa…
View article: 24-Norursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation
24-Norursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation Open
View article: Concentration of Gallbladder Phosphatidylcholine in Cholangiopathies: A Phosphorus‐31 Magnetic Resonance Spectroscopy Pilot Study
Concentration of Gallbladder Phosphatidylcholine in Cholangiopathies: A Phosphorus‐31 Magnetic Resonance Spectroscopy Pilot Study Open
Background Biliary phosphatidylcholine (PtdC) concentration plays a role in the pathogenesis of bile duct diseases. In vivo phosphorus‐31 magnetic resonance spectroscopy ( 31 P‐MRS) at 7 T offers the possibility to assess this concentratio…
View article: Combined effects of PNPLA3, TM6SF2 and HSD17B13 variants on severity of biopsy-proven non-alcoholic fatty liver disease
Combined effects of PNPLA3, TM6SF2 and HSD17B13 variants on severity of biopsy-proven non-alcoholic fatty liver disease Open
Objective Several single-nucleotide polymorphisms have been identified to be disadvantageous or protective in regard to disease severity in patients with non-alcoholic fatty liver disease (NAFLD). However, it is unclear, whether including …
View article: 24-Nor-Ursodeoxycholic acid reshapes immunometabolism in CD8<sup>+</sup>T cells and alleviates hepatic inflammation
24-Nor-Ursodeoxycholic acid reshapes immunometabolism in CD8<sup>+</sup>T cells and alleviates hepatic inflammation Open
Background & Aims 24-NorUrsodeoxycholic acid (NorUDCA) is novel therapy for immune-mediated liver diseases such as primary sclerosing cholangitis (PSC) where dysregulated T cells including CD8 + T cells cause liver immunopathology. We hypo…
View article: Prevalence of anti‐Hepatitis E antibodies and impact on disease severity in non‐alcoholic fatty liver disease
Prevalence of anti‐Hepatitis E antibodies and impact on disease severity in non‐alcoholic fatty liver disease Open
Aim In most immune‐competent individuals, hepatitis E (HEV) infections appear silent. It is unclear whether past HEV infections deteriorate disease severity in patients with non‐alcoholic fatty liver disease (NAFLD). Methods Patients with …
View article: Open-label phase II study evaluating safety and efficacy of the non-steroidal farnesoid X receptor agonist PX-104 in non-alcoholic fatty liver disease
Open-label phase II study evaluating safety and efficacy of the non-steroidal farnesoid X receptor agonist PX-104 in non-alcoholic fatty liver disease Open
View article: Glucuronidation directs systemically available norursodeoxcholic acid (norUDCA) to the kidney
Glucuronidation directs systemically available norursodeoxcholic acid (norUDCA) to the kidney Open
View article: In Vivo <scp><sup>1</sup>H MR</scp> Spectroscopy of Biliary Components of Human Gallbladder at 7T
In Vivo <span><sup>1</sup>H MR</span> Spectroscopy of Biliary Components of Human Gallbladder at 7T Open
Background Previous in vivo proton MR spectroscopy (MRS) studies have demonstrated the possibility of quantifying amide groups of conjugated bile acids (NHCBA), olefinic lipids and cholesterol (OLC), choline‐containing phospholipids (CCPLs…