Emir Malovic
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View article: Emerging role of N6-methyladenosine (m6A) epitranscriptomic changes in adult anxiety after adolescent alcohol exposure
Emerging role of N6-methyladenosine (m6A) epitranscriptomic changes in adult anxiety after adolescent alcohol exposure Open
Adolescent intermittent ethanol (AIE) exposure affects multiple brain regions by producing long-lasting effects on epigenetic mechanisms and behavioral phenotypes later in life. Recently, it has been shown that epigenetic switches can cont…
View article: Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCδ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-related neurodegenerative diseases
Mitochondrial stress disassembles nuclear architecture through proteolytic activation of PKCδ and Lamin B1 phosphorylation in neuronal cells: implications for pathogenesis of age-related neurodegenerative diseases Open
Mitochondrial dysfunction and oxidative stress are central to the pathogenesis of neurodegenerative diseases, including Parkinson’s, Alzheimer’s and Huntington’s diseases. Neurons, particularly dopaminergic (DAergic) ones, are highly vulne…
View article: KCa3.1 Contributes to Neuroinflammation and Nigral Dopaminergic Neurodegeneration in Experimental models of Parkinson’s Disease
KCa3.1 Contributes to Neuroinflammation and Nigral Dopaminergic Neurodegeneration in Experimental models of Parkinson’s Disease Open
Chronic neuroinflammation and misfolded α-synuclein (αSyn) have been identified as key pathological correlates driving Parkinson’s disease (PD) pathogenesis; however, the contribution of ion channels to microglia activation in the context …
View article: Mitochondrial Stress Disassembles Nuclear Architecture through Proteolytic Activation of PKCδ and Lamin B1 Phosphorylation in Neuronal Cells: Implications for Pathogenesis of Age-related Neurodegenerative Diseases
Mitochondrial Stress Disassembles Nuclear Architecture through Proteolytic Activation of PKCδ and Lamin B1 Phosphorylation in Neuronal Cells: Implications for Pathogenesis of Age-related Neurodegenerative Diseases Open
Mitochondrial dysfunction and oxidative stress are hallmarks of pathophysiological processes in age-related neurodegenerative diseases including Parkinson’s, Alzheimer’s and Huntington’s diseases. Neuronal cells are highly vulnerable to mi…
View article: Epitranscriptomic Reader YTHDF2 Regulates SEK1(<i>MAP2K4</i>)-JNK-cJUN Inflammatory Signaling in Astrocytes during Neurotoxic Stress
Epitranscriptomic Reader YTHDF2 Regulates SEK1(<i>MAP2K4</i>)-JNK-cJUN Inflammatory Signaling in Astrocytes during Neurotoxic Stress Open
As the most abundant glial cells in the CNS, astrocytes dynamically respond to neurotoxic stress, however, the key molecular regulators controlling the inflammatory status of these sentinels during neurotoxic stress have remained elusive. …
View article: Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression
Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression Open
To date, there is no cure for Parkinson’s disease (PD). There is a pressing need for anti-neurodegenerative therapeutics that can slow or halt PD progression by targeting underlying disease mechanisms. Specifically, preventing the build-up…
View article: Microglial immune regulation by epigenetic reprogramming through histone H3K27 acetylation in neuroinflammation
Microglial immune regulation by epigenetic reprogramming through histone H3K27 acetylation in neuroinflammation Open
Epigenetic reprogramming is the ability of innate immune cells to form memories of environmental stimuli (priming), allowing for heightened responses to secondary stressors. Herein, we explored microglial epigenetic marks using the known i…
View article: Advances in DNA, histone, and RNA methylation mechanisms in the pathophysiology of alcohol use disorder
Advances in DNA, histone, and RNA methylation mechanisms in the pathophysiology of alcohol use disorder Open
Alcohol use disorder (AUD) has a complex, multifactorial etiology involving dysregulation across several brain regions and peripheral organs. Acute and chronic alcohol consumption cause epigenetic modifications in these systems, which unde…
View article: Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology
Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology Open
Epitranscriptomics, the study of chemically modified RNAs, is a burgeoning field being explored in a variety of scientific disciplines. Of the currently known epitranscriptomic modifications, N6-methyladenosine (m6A) methylation is the mos…
View article: Role of N6-Methyladenosine (m6A) epitranscriptomic mechanisms in manganese-induced astrocyte inflammation
Role of N6-Methyladenosine (m6A) epitranscriptomic mechanisms in manganese-induced astrocyte inflammation Open
Manganese (Mn) is considered an environmental toxicant, known to cause a type of Parkinsonism called manganism. First observed in Mn ore crushers, the overexposure of Mn produces neurological signs and symptoms, predominantly motor impairm…
View article: Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease Open
Characterization of the key cellular targets contributing to sustained microglial activation in neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of these targets can provide potential treatments to hal…
View article: Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells
Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells Open
Alpha-synuclein (αSynAgg) are pathological hallmarks of Parkinson's disease (PD) and other synucleinopathies that induce microglial activation and immune-mediated neurotoxicity, but the molecular mechanisms of αSynAgg-induced immune activa…
View article: Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells Open
Exosomes containing the adaptor ASC spread NLRP3 inflammasome activation between cells after manganese exposure.
View article: Veterinary Considerations for the Theoretical Resurrection of Extinct Species
Veterinary Considerations for the Theoretical Resurrection of Extinct Species Open
The de-extinction of the dinosaur is a dubious possibility but its consideration brings forth some issues that are at least worthy of scientific discussion. In this review, we discuss two distinct issues that have implications for a de-ext…
View article: Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility Open
Microglia are the primary responders to central nervous system insults; however, much remains unknown about their role in regulating neuroinflammation. Microglia are mesodermal cells that function similarly to macrophages in surveying infl…
View article: Theoretical Engineering of the Gut Micro biome for the Purpose of Creating Superior Soldiers
Theoretical Engineering of the Gut Micro biome for the Purpose of Creating Superior Soldiers Open
The purpose of this review is to highlight research raising the possibility of exploiting the host-microbiome gut axis for military purposes. Through optimizing the gut-microbiome environment it is possible to enhance nutritional access to…