Emir Tas
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View article: Impact of Ondansetron Timing on Symptom Burden and Diagnostic Performance During Pediatric Growth Hormone Stimulation Testing
Impact of Ondansetron Timing on Symptom Burden and Diagnostic Performance During Pediatric Growth Hormone Stimulation Testing Open
Ondansetron does not affect GH test outcomes and may reduce symptoms. BMI standard deviation scores (SDS) is an independent predictor of GH response and should be considered in interpreting test results.
View article: Associations Between Serum Gut-Derived Tryptophan Metabolites and Cardiovascular Health Markers in Adolescents with Obesity
Associations Between Serum Gut-Derived Tryptophan Metabolites and Cardiovascular Health Markers in Adolescents with Obesity Open
Background/Objectives: Gut-derived tryptophan (Trp) metabolites play important roles in metabolic and cardiovascular regulation. Although animal studies suggest their protective effects against metabolic dysfunction, data in adolescents, p…
View article: The effect of phlebotomy and placement of an intravenous catheter on plasma catecholamine and serum copeptin concentrations
The effect of phlebotomy and placement of an intravenous catheter on plasma catecholamine and serum copeptin concentrations Open
Objectives Limited data are available on the hormonal response of children to venepuncture or intravenous cannulation (IVC). Catecholamines (epinephrine (E) and norepinephrine (NE)) have been traditionally recognized as stress hormones. Co…
View article: Relationship between liver and cardiometabolic health in type 1 diabetes
Relationship between liver and cardiometabolic health in type 1 diabetes Open
Introduction Type 1 diabetes (T1D) is a chronic condition marked by insulin deficiency and hyperglycemia, with an increasing global incidence, particularly among children. Despite improvements in diabetes management, individuals with T1D c…
View article: Diagnostic Accuracy of Transient Elastography in Hepatosteatosis in Youth With Obesity
Diagnostic Accuracy of Transient Elastography in Hepatosteatosis in Youth With Obesity Open
Context Steatotic liver disease is common but overlooked in childhood obesity; diagnostic methods are invasive or expensive. Objective We sought to determine the diagnostic accuracy of vibration-controlled transient elastography (VCTE) com…
View article: Neonatal diabetes mellitus May Offer the Missing Link to monogenic diabetes in family members: A case report
Neonatal diabetes mellitus May Offer the Missing Link to monogenic diabetes in family members: A case report Open
Neonatal diabetes mellitus (NDM) is a rare type of monogenic diabetes. It is predominantly described as insulin-requiring hyperglycemia before the age of 6 months. Diagnosis of NDM can be difficult due to its varying clinical presentation.…
View article: OR15-06 Measuring Hepatic Steatosis With Transient Elastography In Adolescents With Obesity
OR15-06 Measuring Hepatic Steatosis With Transient Elastography In Adolescents With Obesity Open
Disclosure: D. Sundararajan: None. J.S. Lo: None. N. Morelli: None. Y. Garcia-Reyes: None. M.A. Ware: None. H. Rahat: None. S. Sundaram: None. C. Severn: None. L.L. Pyle: None. E. Tas: None. M.G. Cree: Consulting Fee; Self; Pollie, Inc. Re…
View article: Metformin use is associated with decreased asthma exacerbations in adolescents and young adults
Metformin use is associated with decreased asthma exacerbations in adolescents and young adults Open
Rationale Metformin is a commonly used antidiabetes medication with suggested anti‐inflammatory and antioxidative effects. Metformin use has been associated with lower risk of asthma exacerbations and hospitalizations in adults. Here, we a…
View article: Effects of short‐term supervised exercise training on liver fat in adolescents with obesity: a randomized controlled trial
Effects of short‐term supervised exercise training on liver fat in adolescents with obesity: a randomized controlled trial Open
Objective The objective of this study was to quantify the effects of a 4‐week, supervised, high‐intensity interval training (HIIT) on intrahepatic triglyceride content (IHTG, percentage), cardiorespiratory fitness (CRF), and cardiometaboli…
View article: Pediatric Obesity: Complications and Current Day Management
Pediatric Obesity: Complications and Current Day Management Open
Obesity affects approximately 1 in 5 youth globally and increases the risk of complications during adolescence and young adulthood, including type 2 diabetes, dyslipidemia, hypertension, non-alcoholic fatty liver disease, obstructive sleep…
View article: Case report: A proposed role for cardiopulmonary exercise testing in detecting cardiac dysfunction in asymptomatic at-risk adolescents
Case report: A proposed role for cardiopulmonary exercise testing in detecting cardiac dysfunction in asymptomatic at-risk adolescents Open
Noninvasive cardiopulmonary exercise testing (CPET) provides the valuable capacity to analyze pulmonary gas exchange and cardiovascular responses that can be used to differentiate normal cardiopulmonary responses from abnormal. This case r…
View article: Obesity, but not glycemic control, predicts liver steatosis in children with type 1 diabetes
Obesity, but not glycemic control, predicts liver steatosis in children with type 1 diabetes Open
The clinical and imaging findings of children with T1D and obesity are comparable to non-diabetic children with a similar degree of obesity. Obesity is the major risk factor for NAFLD in pediatric T1D. BMI, HDL-c, and BMI/HDL ratio may be …
View article: Circulating microRNAs Are Associated With Metabolic Markers in Adolescents With Hepatosteatosis
Circulating microRNAs Are Associated With Metabolic Markers in Adolescents With Hepatosteatosis Open
Background Altered hepatic microRNA (miRNA) expression may play a role in the development of insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). Circulating miRNAs could mirror the liver metabolism. Objective This study …
View article: Treatment of Growth Hormone Deficiency via Daily Intravascular Injections in a Child with Bleeding Disorder
Treatment of Growth Hormone Deficiency via Daily Intravascular Injections in a Child with Bleeding Disorder Open
Objectives . The standard of treatment for pediatric growth hormone deficiency (GHD) is daily subcutaneous recombinant human growth hormone (rhGH) injections. The efficacy of rhGH treatment given as daily intravenous (IV) boluses is not kn…
View article: <p>Circulating miRNA Signatures Associated with Insulin Resistance in Adolescents with Obesity</p>
Circulating miRNA Signatures Associated with Insulin Resistance in Adolescents with Obesity Open
Specific signatures of circulating miRNAs reflected metabolic phenotypes and predicted the presence of IR in adolescents with obesity, suggesting that miRNA indicators may identify obesity-associated complications in childhood. Further stu…
View article: Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity
Fibroblast Growth Factor-21 to Adiponectin Ratio: A Potential Biomarker to Monitor Liver Fat in Children With Obesity Open
Background: There is a pressing need for effective and non-invasive biomarkers to track intrahepatic triglyceride (IHTG) in children at-risk for non-alcoholic fatty liver disease (NAFLD), as standard-of-care reference tools, liver biopsy a…
View article: A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant
A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant Open
Hypercalcemia is an uncommon finding in children. Hypercalcemia has various etiologies including parathyroid dependent and independent mechanisms. Increased activity of the 1-alpha-hydroxylase enzyme in granulomatous diseases is a well-def…
View article: SUN-128 Novel Mutation in the HNF1A Gene in Siblings Previously Diagnosed with Type 1 Diabetes
SUN-128 Novel Mutation in the HNF1A Gene in Siblings Previously Diagnosed with Type 1 Diabetes Open
Introduction: Maturity Onset Diabetes of the Young (MODY) is a monogenic type of diabetes, frequently misdiagnosed as Type 1 diabetes. Previous studies have shown that MODY makes up about 1.1% of all diabetes cases among children 0-14 year…
View article: SAT-501 A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant
SAT-501 A Rare and Potentially Fatal Etiology of Hypercalcemia in an Infant Open
Background: Increased 1alpha-hydroxylase activity in granulomatous diseases is a well-defined cause of hypercalcemia. Disseminated fungal infections are a rare cause of granulomatous diseases in immunocompetent children. Clinical Case: A 7…
View article: Humanin is an endogenous activator of chaperone-mediated autophagy
Humanin is an endogenous activator of chaperone-mediated autophagy Open
Chaperone-mediated autophagy (CMA) serves as quality control during stress conditions through selective degradation of cytosolic proteins in lysosomes. Humanin (HN) is a mitochondria-associated peptide that offers cytoprotective, cardiopro…
View article: Investigating the link of <i>ACAD10</i> deficiency to type 2 diabetes mellitus
Investigating the link of <i>ACAD10</i> deficiency to type 2 diabetes mellitus Open
The Native American Pima population has the highest incidence of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) of any reported population, but the pathophysiologic mechanism is unknown. Genetic studies in Pima Indians have li…