Emma Ahlén Bergman
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View article: Supplemental figure S1-S7 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Supplemental figure S1-S7 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Supplemental figure 1 illustrates gating strategy appliead to FACS data. Supplemental figure 2 shows gene expression correlation to Treg frequency overlaid on KEGG bladder cancer pathway. Supplemental figure 3 shows expression of functiona…
View article: Tables S1, S2 and S3 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Tables S1, S2 and S3 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Table S1 shows patient characteristics. Table S2 summarizes the antibodies used. Table S3 shows primer sequences used.
View article: Tables S1, S2 and S3 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Tables S1, S2 and S3 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Table S1 shows patient characteristics. Table S2 summarizes the antibodies used. Table S3 shows primer sequences used.
View article: Data from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Data from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Regulatory T cells (Treg) have long been considered one-sided suppressors of antitumor immune responses and hence associated with poor patient outcome in cancer. However, evidence is mounting of a paradoxical positive prognostic effect of …
View article: Supplemental figure S1-S7 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Supplemental figure S1-S7 from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Supplemental figure 1 illustrates gating strategy appliead to FACS data. Supplemental figure 2 shows gene expression correlation to Treg frequency overlaid on KEGG bladder cancer pathway. Supplemental figure 3 shows expression of functiona…
View article: Data from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness
Data from Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness Open
Regulatory T cells (Treg) have long been considered one-sided suppressors of antitumor immune responses and hence associated with poor patient outcome in cancer. However, evidence is mounting of a paradoxical positive prognostic effect of …
View article: Genetic variability in exon 1 of the glucocorticoid receptor gene NR3C1 is associated with postoperative complications
Genetic variability in exon 1 of the glucocorticoid receptor gene NR3C1 is associated with postoperative complications Open
Patients undergoing major surgery experience postoperative inflammation, which may contribute to postoperative morbidity. Endogenous glucocorticoids (GCs) are an essential part of the stress response, but this response varies between indiv…
View article: Tumour‐associated B cells in urothelial urinary bladder cancer
Tumour‐associated B cells in urothelial urinary bladder cancer Open
Tumour infiltrating B cells and CD38 + plasma cells have been correlated with survival in different malignancies but their role in urinary bladder cancer is unclear. IL‐10 is a multifunctional cytokine with both anti‐inflammatory and immun…
View article: Municipal Solid Waste Management in Informal Settlements – A multiple-case study of challenges and possibilities in the favelas and informal sector of Rio de Janeiro city
Municipal Solid Waste Management in Informal Settlements – A multiple-case study of challenges and possibilities in the favelas and informal sector of Rio de Janeiro city Open
Today, about one billion people in the world live in informal settlements and lack access to basic services and city infrastructure. In Rio de Janeiro, approximately 1,4 million people, one fourth of the city population, live in informal s…
View article: Locus specific DNA methylation in human immunological responses
Locus specific DNA methylation in human immunological responses Open
All cells in the human body contains the same genome. Yet, there are hundreds of different cell types, with widely different phenotype, and function. The differential gene expression leading to this diversity is tightly regulated by epigen…
View article: Increased CD4+ T cell lineage commitment determined by CpG methylation correlates with better prognosis in urinary bladder cancer patients
Increased CD4+ T cell lineage commitment determined by CpG methylation correlates with better prognosis in urinary bladder cancer patients Open
Increased lineage commitment in CD4+ T cells, as determined by demethylation in predictive CpG sites, is associated with lower post-cystectomy tumour stage, complete response to neoadjuvant chemotherapy and overall better outcome, suggesti…
View article: Tissue-resident memory T cells are epigenetically cytotoxic with signs of exhaustion in human urinary bladder cancer
Tissue-resident memory T cells are epigenetically cytotoxic with signs of exhaustion in human urinary bladder cancer Open
Summary Tissue-resident memory T (TRM) cells are CD8+ T lymphocytes that reside in the tissues, including tumours. This T cell subset possesses a magnitude of cytotoxicity, but its epigenetic regulation has not been studied. Here, we inves…
View article: Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway
Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway Open
The immune system plays a significant role in urothelial bladder cancer (UBC) progression, with CD8+ T cells being capable to directly kill tumor cells using perforin and granzymes. However, tumors avoid immune recognition by escape mechan…
View article: 0073 DYNAMIC CHANGES IN HUMAN INNATE AND ADAPTIVE IMMUNE CELL NUMBERS IN RESPONSE TO SLEEP EXTENSION AND SLEEP DEPRIVATION
0073 DYNAMIC CHANGES IN HUMAN INNATE AND ADAPTIVE IMMUNE CELL NUMBERS IN RESPONSE TO SLEEP EXTENSION AND SLEEP DEPRIVATION Open
It has not been determined if innate and adaptive immune cell counts change following sleep extension (EXT). Here, we combine 2-days of baseline (8 h time-in-bed), 1-week of EXT (10 h time-in-bed) immediately followed by sleep deprivation …
View article: Levels of physical activity in people with chronic pain
Levels of physical activity in people with chronic pain Open
Background: People who suffer from chronic pain are thought to have lower levels of physical activity compared to healthy individuals. However, there is a lack of evidence concerning levels of physical activity in South Africans with chron…
View article: B cells in tumor draining lymph nodes act as efficient antigen presenting cells in cancer patients
B cells in tumor draining lymph nodes act as efficient antigen presenting cells in cancer patients Open
Meeting abstracts Overall Survival of patients with muscle invasive urothelial bladder cancer MIBC remains around 50% (5 years), albeit some improvements by combining neoadjuvant chemotherapy with radical surgery. Our previous work has dem…