Emma Amjad
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View article: Oral supplementation of fucoxanthin regulates gene expression in the brain of middle-aged rats
Oral supplementation of fucoxanthin regulates gene expression in the brain of middle-aged rats Open
Age is the main risk factor for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia. Despite our limited understanding of cellular mechanisms of ageing-associated neuronal loss, an i…
Mitochondrial protective potential of fucoxanthin in brain disorders Open
Mitochondrial dysfunction is a common feature of brain disorders. Mitochondria play a central role in oxidative phosphorylation; thus changes in energy metabolism in the brain have been reported in conditions such as Alzheimer’s disease, P…
Bcl-xL Is Required by Primary Hippocampal Neurons during Development to Support Local Energy Metabolism at Neurites Open
B-cell lymphoma-extra large (Bcl-xL) is a mitochondrial protein known to inhibit mitochondria-dependent intrinsic apoptotic pathways. An increasing number of studies have demonstrated that Bcl-xL is critical in regulating neuronal energy m…
Depletion of Bcl-xL Impairs Mitochondrial Motility in Primary Hippocampal Neurons Open
OBJECTIVES: B-cell lymphoma-extra large (Bcl-xL) is a pro-survival protein localized to mitochondria and is also reported to support brain function by enhancing neuronal energy metabolism and synapse formation. We have previously shown tha…