Emma Batchen
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View article: Glucocorticoid receptor alters isovolumetric contraction and restrains cardiac fibrosis
Glucocorticoid receptor alters isovolumetric contraction and restrains cardiac fibrosis Open
Corticosteroids directly affect the heart and vasculature and are implicated in the pathogenesis of heart failure. Attention is focussed upon the role of the mineralocorticoid receptor (MR) in mediating pro-fibrotic and other adverse effec…
View article: Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate
Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate Open
Insufficient alveolar gas exchange capacity is a major contributor to lung disease. During lung development, a population of distal epithelial progenitors first produce bronchiolar-fated and subsequently alveolar-fated progeny. The mechani…
View article: Moderated Poster Session - Heart245The involvement of TWEAK and FN14 in murine autoimmune myocarditis246Sympathetic neurons that innervate the heart locally modulate cardiomyocyte trophic and electrophysiological properties247W4R variant of CSRP3 leads to the expression of a novel alternate reading frame protein due to alternative splicing248Glucocorticoid intervention prenatally: effects on fetal heart maturation249Uncoupling of myofilament Ca2+-sensitivity from troponin I phosphorylation by hypertrophic and dilated cardiomyopathy mutations can be reversed by EGCG and related Hsp90 inhibitors250Investigating inherited HCM caused by SCO2 and PRKAG2 mutations using the patients' induced pluripotent stem cell-derived cardiomyocytes
Moderated Poster Session - Heart245The involvement of TWEAK and FN14 in murine autoimmune myocarditis246Sympathetic neurons that innervate the heart locally modulate cardiomyocyte trophic and electrophysiological properties247W4R variant of CSRP3 leads to the expression of a novel alternate reading frame protein due to alternative splicing248Glucocorticoid intervention prenatally: effects on fetal heart maturation249Uncoupling of myofilament Ca2+-sensitivity from troponin I phosphorylation by hypertrophic and dilated cardiomyopathy mutations can be reversed by EGCG and related Hsp90 inhibitors250Investigating inherited HCM caused by SCO2 and PRKAG2 mutations using the patients' induced pluripotent stem cell-derived cardiomyocytes Open
Background: Myocarditis, defined as an inflammation of the myocardium, can be caused by autoimmune reactions. To study these immune reactions our group developed a mouse model of experimental autoimmune myocarditis (EAM). Little is known a…