Emma Bergsten
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View article: The <i>E. coli</i> CNF1 toxin induces fetal reprogramming of intestinal stem cells and a serrated colorectal cancer transcriptional signature in organoids
The <i>E. coli</i> CNF1 toxin induces fetal reprogramming of intestinal stem cells and a serrated colorectal cancer transcriptional signature in organoids Open
SUMMARY Mechanistic insights are essential to understand how gut microbiota pathobionts contribute to tumorigenesis, given the mounting evidence linking them to colorectal cancer. We report a higher prevalence of the Rho GTPases-targeting …
View article: Parvimonas micra alters gut microbiota and promotes tumor growth through DNA methylation
Parvimonas micra alters gut microbiota and promotes tumor growth through DNA methylation Open
Oral commensals such as Parvimonas micra are increasingly implicated in sporadic colorectal cancer (CRC). Several findings support an emerging notion that alterations in host DNA methylation constitute a mechanism by which P. micra adapts …
View article: Colorectal cancer patient outcome is influenced by tumour-adherent bacteria through epigenetic regulation of cardinal genes including PHLPP1
Colorectal cancer patient outcome is influenced by tumour-adherent bacteria through epigenetic regulation of cardinal genes including PHLPP1 Open
Objective How tumour-adherent microbiome can influence outcomes in patients with colorectal cancer (CRC). Methods and analysis CRC tissues (n=97) were analysed using RNAseq, whole exome sequencing (WES) and 16 r sRNA sequencing. Inflammato…
View article: Poor prognosis in IBD-complicated colon cancer through gut dysbiosis-related immune response failure
Poor prognosis in IBD-complicated colon cancer through gut dysbiosis-related immune response failure Open
Summary Background Colorectal cancer (CRC) results from the accumulation of mutations and epigenetic changes in gut epithelial cells likely due to gut microbiota dysbiosis. However, limited research has been done to explore the link betwee…
View article: The colibactin-producing <i>Escherichia coli</i> alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance
The colibactin-producing <i>Escherichia coli</i> alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance Open
Intratumoral bacteria flexibly contribute to cellular and molecular tumor heterogeneity for supporting cancer recurrence through poorly understood mechanisms. Using spatial metabolomic profiling technologies and 16SrRNA sequencing, we here…
View article: <i>Parvimonas micra</i> , an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes
<i>Parvimonas micra</i> , an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes Open
Recently, an intestinal dysbiotic microbiota with enrichment in oral cavity bacteria has been described in colorectal cancer (CRC) patients. Here, we characterize and investigate one of these oral pathobionts, the Gram-positive anaerobic c…
View article: The Colibactin-Producing<i>Escherichia coli</i>alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance
The Colibactin-Producing<i>Escherichia coli</i>alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance Open
Intratumoral bacteria locally contribute to cellular and molecular tumor heterogeneity that support cancer stemness through poorly understood mechanisms. This study aims to explore how Colibactin-producing Escherichia coli (CoPEC) flexibly…
View article: <i>Parvimonas micra</i>, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human primary intestinal epithelial cells
<i>Parvimonas micra</i>, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human primary intestinal epithelial cells Open
Summary Recently, an intestinal dysbiotic microbiota with enrichment in oral cavity bacteria has been described in colorectal cancer (CRC) patients. Here we characterized and investigated one of these oral pathobionts, the Gram-positive an…
View article: Detection of Streptococcus gallolyticus and Four Other CRC-Associated Bacteria in Patient Stools Reveals a Potential “Driver” Role for Enterotoxigenic Bacteroides fragilis
Detection of Streptococcus gallolyticus and Four Other CRC-Associated Bacteria in Patient Stools Reveals a Potential “Driver” Role for Enterotoxigenic Bacteroides fragilis Open
Purpose Streptococcus gallolyticus subspecies gallolyticus ( SGG ) is an opportunistic pathogen causing invasive infections in the elderly often associated with colon neoplasia. The prevalence of SGG in the stools of patients with normal c…
View article: Virulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts
Virulent Bacteria as Inflammatory and Immune Co-Factor in Colon Carcinogenesis: Evidence From Two Monozygotic Patients and Validation in CRC Patient and Healthy Cohorts Open
Colorectal carcinoma (CRC) is a common disease, the incidence of which is increasing according to Western lifestyle; it remains to have a poor prognosis. Western nutriments are presumed to induce mild inflammation within the colonic mucosa…
View article: The Limits and Avoidance of Biases in Metagenomic Analyses of Human Fecal Microbiota
The Limits and Avoidance of Biases in Metagenomic Analyses of Human Fecal Microbiota Open
An increasing body of evidence highlights the role of fecal microbiota in various human diseases. However, more than two-thirds of fecal bacteria cannot be cultivated by routine laboratory techniques. Thus, physicians and scientists use DN…
View article: Virulent Bacteria as A Co-factor of Colon Carcinogenesis: Evidence from Two Monozygotic Patients
Virulent Bacteria as A Co-factor of Colon Carcinogenesis: Evidence from Two Monozygotic Patients Open
Colorectal carcinoma (CRC) is a common disease with a poor prognosis.CRC results from the accumulation of DNA alterations in colonocytes through a multistage carcinogenesis process.Most CRCs are related to the environment, which influences…
View article: Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures
Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures Open
Sporadic colorectal cancer (CRC) is a result of complex interactions between the host and its environment. Environmental stressors act by causing host cell DNA alterations implicated in the onset of cancer. Here we investigate the stressor…
View article: Extensive transmission of microbes along the gastrointestinal tract
Extensive transmission of microbes along the gastrointestinal tract Open
The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral species to the intestine is considered a rare aberrant event, and a hallmark of disease. By studying salivary and fecal microbial strain populati…
View article: Author response: Extensive transmission of microbes along the gastrointestinal tract
Author response: Extensive transmission of microbes along the gastrointestinal tract Open
Article Figures and data Abstract eLife digest Introduction Results and discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The gastrointestinal trac…
View article: “Extensive Transmission of Microbes along the Gastrointestinal Tract”
“Extensive Transmission of Microbes along the Gastrointestinal Tract” Open
The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral species to the intestine is considered a rare aberrant event, and a hallmark of disease. By studying salivary and fecal microbial strain populati…
View article: Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice
Neural Mechanisms Underlying the Disruption of Male Courtship Behavior by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice Open
These data demonstrate the critical role of neural AR in courtship vocalizations and raises the possibility that the vulnerability of this signaling pathway to exposure to endocrine disrupters may be detrimental for courtship communication…
View article: Sjuksköterskans attityd till att involvera patientens närstående i vården : en litteraturstudie
Sjuksköterskans attityd till att involvera patientens närstående i vården : en litteraturstudie Open
Introduktion: Sjuksköterskan möter dagligen närstående i sin yrkesroll inom nästan alla vårdkontext och det ingår i sjuksköterskans profession att involvera patientens närstående i vården. Kvaliteten av mötet med närstående påverkas av sju…
View article: Samma fordon, olika cyklister: En nyansering av den cyklande arbetspendlaren
Samma fordon, olika cyklister: En nyansering av den cyklande arbetspendlaren Open
Denna studie har berört problematiken med utsläpp relaterade till trafikstockning i storstadsregioner. Trängsel uppstår ofta i samband med arbetspendling, varför en trafikomställning mot mer hållbara färdmedel är önskvärd. Cykeln som trans…