Emma Bishop
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View article: PP86 Development Of A Tool To Assist In The Identification Of Study Designs For The Purposes Of Health Technology Assessment
PP86 Development Of A Tool To Assist In The Identification Of Study Designs For The Purposes Of Health Technology Assessment Open
Introduction As the most internally rigorous design, randomized controlled trials (RCTs) are the gold standard for assessing the efficacy and safety profile of interventions. Increasingly, health technology assessment (HTA) considers evide…
View article: Comparative toxicological assessment of cigarettes and new category products via an in vitro multiplex proteomics platform
Comparative toxicological assessment of cigarettes and new category products via an in vitro multiplex proteomics platform Open
View article: Multi-endpoint in vitro toxicological assessment of snus and tobacco-free nicotine pouch extracts
Multi-endpoint in vitro toxicological assessment of snus and tobacco-free nicotine pouch extracts Open
'Modern' oral tobacco-free nicotine pouches (NPs) are a nicotine containing product similar in appearance and concept to Swedish snus. A three-step approach was taken to analyse the biological effects of NPs and snus extracts in vitro. Tox…
View article: An in vitro toxicological assessment of two electronic cigarettes: E-liquid to aerosolisation
An in vitro toxicological assessment of two electronic cigarettes: E-liquid to aerosolisation Open
View article: Advances in whole aerosol approaches for in vitro e‐cigarette testing
Advances in whole aerosol approaches for in vitro e‐cigarette testing Open
Electronic‐cigarette regulation and risk assessment is a prominent and developing field, as the popularity and prevalence of this product category increases. Over the last 10 years since their emergence, there have been many advances and a…
View article: Design and Usability of an Avatar-Based Learning Program to Support Diabetes Education: Quality Improvement Study in Colombia
Design and Usability of an Avatar-Based Learning Program to Support Diabetes Education: Quality Improvement Study in Colombia Open
Background: This quality improvement study, entitled Avatar-Based LEarning for Diabetes Optimal Control (ABLEDOC), explored the feasibility of delivering an educational program to people with diabetes in Colombia. The aim was to discover h…
View article: Hybran: Hybrid Reference Transfer and ab initio Prokaryotic Genome Annotation
Hybran: Hybrid Reference Transfer and ab initio Prokaryotic Genome Annotation Open
De novo assembly has become commonplace for microbial organisms, increasing the demand for reliable genome annotation. Ab initio annotation is not an ideal approach for closely related strains due to suboptimal matching of the short or hyp…
View article: A 3D in vitro comparison of two undiluted e-cigarette aerosol generating systems
A 3D in vitro comparison of two undiluted e-cigarette aerosol generating systems Open
In vitro studies play an important role in supporting the toxicological assessment of e-cigarettes, with many current methods reliant on sophisticated in vitro exposure systems designed for conventional cigarette testing. In this study, we…
View article: A screening approach for the evaluation of tobacco-free ‘modern oral’ nicotine products using Real Time Cell Analysis
A screening approach for the evaluation of tobacco-free ‘modern oral’ nicotine products using Real Time Cell Analysis Open
View article: Optimization of aqueous aerosol extract (AqE) generation from e-cigarettes and tobacco heating products for in vitro cytotoxicity testing
Optimization of aqueous aerosol extract (AqE) generation from e-cigarettes and tobacco heating products for in vitro cytotoxicity testing Open
Electronic cigarettes (e-cigarettes) and tobacco heating products (THPs) have reduced yields of toxicants and have recently emerged as a potentially safer alternative to combustible cigarettes. To understand if reduced toxicant exposure is…
View article: An approach for the extract generation and toxicological assessment of tobacco-free ‘modern’ oral nicotine pouches
An approach for the extract generation and toxicological assessment of tobacco-free ‘modern’ oral nicotine pouches Open
Tobacco-free 'modern' oral nicotine pouches (MOPs), are similar in appearance and use to Swedish-style snus, but without tobacco. There are few identified methods to create test samples for toxicologically assessment of MOPs in vitro. In t…
View article: Evaluation of a high-throughput in vitro endothelial cell migration assay for the assessment of nicotine and tobacco delivery products
Evaluation of a high-throughput in vitro endothelial cell migration assay for the assessment of nicotine and tobacco delivery products Open
Endothelial cell migration is a critical process in the maintenance of healthy blood vessels. Impaired endothelial migration is reportedly associated with the development of cardiovascular diseases. Here, we report on the development of a …
View article: An approach to testing undiluted e-cigarette aerosol in vitro using 3D reconstituted human airway epithelium
An approach to testing undiluted e-cigarette aerosol in vitro using 3D reconstituted human airway epithelium Open
The data presented here show that to provide an estimate of the relative cytotoxicity and therefore potency of e-cigarettes, undiluted aerosol techniques can be used. With the emergence of electronic nicotine delivery systems, fit-for-purp…
View article: A novel hybrid tobacco product that delivers a tobacco flavour note with vapour aerosol (Part 2): In vitro biological assessment and comparison with different tobacco-heating products
A novel hybrid tobacco product that delivers a tobacco flavour note with vapour aerosol (Part 2): In vitro biological assessment and comparison with different tobacco-heating products Open
This study assessed the toxicological and biological responses of aerosols from a novel hybrid tobacco product. Toxicological responses from the hybrid tobacco product were compared to those from a commercially available Tobacco Heating Pr…
View article: Examination of the use of human sera as an exposure agent for in vitro studies investigating the effects of cigarette smoking on cellular cardiovascular disease models
Examination of the use of human sera as an exposure agent for in vitro studies investigating the effects of cigarette smoking on cellular cardiovascular disease models Open
In vitro models of smoking-related diseases and disease processes are valuable for mechanistic understanding and assessment of novel tobacco products. Many laboratories have used particulate phase or aqueous extracts of cigarette smoke as …