Emma C. L. Cook
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View article: Dendritic cells in energy balance regulation
Dendritic cells in energy balance regulation Open
Besides their well-known role in initiating adaptive immune responses, several groups have studied the role of dendritic cells (DCs) in the context of chronic metabolic inflammation, such as in diet-induced obesity (DIO) or metabolic-assoc…
View article: Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity
Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity Open
View article: Inoculation of the Leishmania infantum HSP70-II Null Mutant Induces Long-Term Protection against L. amazonensis Infection in BALB/c Mice
Inoculation of the Leishmania infantum HSP70-II Null Mutant Induces Long-Term Protection against L. amazonensis Infection in BALB/c Mice Open
Leishmania amazonensis parasites are etiological agents of cutaneous leishmaniasis in the New World. BALB/c mice are highly susceptible to L. amazonensis challenge due to their inability to mount parasite-dependent IFN-γ-mediated responses…
View article: Resistance to Experimental Visceral Leishmaniasis in Mice Infected With Leishmania infantum Requires Batf3
Resistance to Experimental Visceral Leishmaniasis in Mice Infected With Leishmania infantum Requires Batf3 Open
Unveiling the protective immune response to visceral leishmaniasis is critical for a rational design of vaccines aimed at reducing the impact caused by this fatal, if left untreated, vector-borne disease. In this study we sought to determi…
View article: SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity
SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity Open
Intracellular pathogens have evolved strategies to evade detection by cytotoxic CD8+ T lymphocytes (CTLs). Here, we ask whether Leishmania parasites trigger the SHP-1-FcRγ chain inhibitory axis to dampen antigen cross-presentati…
View article: Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity
Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity Open
View article: Subcutaneous Immunization of Leishmania HSP70-II Null Mutant Line Reduces the Severity of the Experimental Visceral Leishmaniasis in BALB/c Mice
Subcutaneous Immunization of Leishmania HSP70-II Null Mutant Line Reduces the Severity of the Experimental Visceral Leishmaniasis in BALB/c Mice Open
Leishmania infantum parasites cause a severe form of visceral leishmaniasis in human and viscerocutaneous leishmaniasis in dogs. Recently, we reported that immunization with an attenuated L. infantum cell line, lacking the hsp70-II gene, p…
View article: <i>Leishmania</i> Triggering of SHP-1 in Dendritic Cells Inhibits Antigen Cross-Presentation to Cd8 <sup>+</sup> T Cells
<i>Leishmania</i> Triggering of SHP-1 in Dendritic Cells Inhibits Antigen Cross-Presentation to Cd8 <sup>+</sup> T Cells Open
View article: Fine-tuning protein recycling to control cholesterol homeostasis
Fine-tuning protein recycling to control cholesterol homeostasis Open
Intracellular levels of cholesterol are paramount to regulating cholesterol levels in blood. The Ubiquitin Proteasome System (UPS) can regulate the expression and activity of the master regulators of cholesterol levels in the cell: SREBP2 …
View article: Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis
Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis Open
Our findings establish UBE2J2 as an important partner of MARCH6 in cholesterol-stimulated degradation of SQLE, thereby contributing to the complex regulation of cellular cholesterol homeostasis.
View article: Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene
Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene Open
Cellular cholesterol metabolism is subject to tight regulation to maintain adequate levels of this central lipid molecule. Herein, the sterol-responsive Liver X Receptors (LXRs) play an important role owing to their ability to reduce cellu…
View article: EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux
EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux Open
Objective— The sterol-responsive nuclear receptors, liver X receptors α (LXRα, NR1H3 ) and β (LXRβ, NR1H2 ), are key determinants of cellular cholesterol homeostasis. LXRs are activated under conditions of high cellular sterol load and ind…
View article: Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake
Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake Open
Cholesterol metabolism is subject to complex transcriptional and nontranscriptional regulation. Herein, the role of ubiquitylation is emerging as an important post-translational modification that regulates cholesterol synthesis and uptake.…
View article: A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes
A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes Open
Cholesterol synthesis and lipoprotein uptake are tightly coordinated to ensure that the cellular level of cholesterol is adequately maintained. Hepatic dysregulation of these processes is associated with pathological conditions, most notab…