Emma Derrett‐Smith
YOU?
Author Swipe
View article: P124 Autoantibody subgroups in diffuse cutaneous systemic sclerosis show contrasting myofibroblast differentiation by bulk and single-cell RNA sequencing
P124 Autoantibody subgroups in diffuse cutaneous systemic sclerosis show contrasting myofibroblast differentiation by bulk and single-cell RNA sequencing Open
Background/Aims Myofibroblasts are important in the pathogenesis of systemic sclerosis (SSc). TGFβ is a key growth factor driving myofibroblast formation and differentiation; however, the downstream signaling pathways regulated by TGFβ dur…
View article: The 2024 British Society for Rheumatology guideline for management of systemic sclerosis—executive summary
The 2024 British Society for Rheumatology guideline for management of systemic sclerosis—executive summary Open
This guideline was developed according to the British Society for Rheumatology Guidelines Protocol by a Guideline Development Group comprising healthcare professionals with expertise in SSc and people with lived experience, as well as pati…
View article: The 2024 British Society for Rheumatology guideline for management of systemic sclerosis
The 2024 British Society for Rheumatology guideline for management of systemic sclerosis Open
This guideline was developed according to the British Society for Rheumatology Guidelines Protocol by a Guideline Development Group comprising healthcare professionals with expertise in SSc and people with lived experience, as well as pati…
View article: Chloride intracellular channel 4 (CLIC4) is a global regulator of type 1 interferon signaling in Systemic Sclerosis (SSc) epithelial cells
Chloride intracellular channel 4 (CLIC4) is a global regulator of type 1 interferon signaling in Systemic Sclerosis (SSc) epithelial cells Open
Objectives Systemic sclerosis (SSc) is an autoimmune disease in which an immune-related injury induces fibrosis of the skin, progressing to affect the internal organs in the most serve cases. Type 1 interferon (IFN) signaling plays a major…
View article: Clinical trajectories of hand function impairment in systemic sclerosis: an unmet clinical need across disease subsets
Clinical trajectories of hand function impairment in systemic sclerosis: an unmet clinical need across disease subsets Open
Background Hand involvement is an early manifestation of systemic sclerosis (SSc), culprit of diagnosis and classification, and recognised major driver of disability. Impairment of hand function burdens both limited and diffuse cutaneous s…
View article: CPC11 Immune checkpoint inhibitor-associated eosinophilic fasciitis: a case report
CPC11 Immune checkpoint inhibitor-associated eosinophilic fasciitis: a case report Open
A 67-year-old man presented with a 3-month history of skin tightness associated with shooting, burning pains and numbness on both his upper and lower limbs. The patient had a background of metastatic bladder cancer, treated with six cycles…
View article: Skin biopsy analysis of concurrent keloidal morphoea and systemic sclerosis confirms overlapping pathogenic pathways
Skin biopsy analysis of concurrent keloidal morphoea and systemic sclerosis confirms overlapping pathogenic pathways Open
Understanding the biology of keloidal morphoea may give valuable insight into the molecular and cellular pathology of systemic sclerosis. The discrete nature of keloidal lesions raises the possibility of haematogenous spread and we suggest…
View article: Management of systemic sclerosis: British Society for Rheumatology guideline scope
Management of systemic sclerosis: British Society for Rheumatology guideline scope Open
This guideline will provide a practical roadmap for management of SSc that builds upon the previous treatment guideline to incorporate advances in evidence-based treatment and increased knowledge about assessment, classification and manage…
View article: A genomic meta-analysis of clinical variables and their association with intrinsic molecular subsets in systemic sclerosis
A genomic meta-analysis of clinical variables and their association with intrinsic molecular subsets in systemic sclerosis Open
Objectives Four intrinsic molecular subsets (inflammatory, fibroproliferative, limited, normal-like) have previously been identified in SSc and are characterized by unique gene expression signatures and pathways. The intrinsic subsets have…
View article: P229 Integrated analysis of dermal blister fluid proteomics and skin biopsy transcriptomics gives new insight into pathogenesis of systemic sclerosis
P229 Integrated analysis of dermal blister fluid proteomics and skin biopsy transcriptomics gives new insight into pathogenesis of systemic sclerosis Open
Background/Aims Suction blister fluid (BF) provides a unique opportunity to analyse the dermal microenvironment of SSc. We utilised an integrated approach to analyse proteomic data from dermal interstitial fluid and genome-wide transcripto…
View article: The value of ultrasound-defined tenosynovitis and synovitis in the prediction of persistent arthritis
The value of ultrasound-defined tenosynovitis and synovitis in the prediction of persistent arthritis Open
Objectives The value of US-defined tenosynovitis in predicting the persistence of inflammatory arthritis is not well described. In particular, the predictive utility of US-defined tenosynovitis of larger tendons is yet to be reported. We a…
View article: Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation
Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-β/Wnt3a Is Mediated by GLI2 Upregulation Open
Chloride intracellular channel 4 (CLIC4) is a recently discovered driver of fibroblast activation in Scleroderma (SSc) and cancer-associated fibroblasts (CAF). CLIC4 expression and activity are regulated by TGF-β signalling through the SMA…
View article: Outcomes linked to eligibility for stem cell transplantation trials in diffuse cutaneous systemic sclerosis
Outcomes linked to eligibility for stem cell transplantation trials in diffuse cutaneous systemic sclerosis Open
Objectives The aim of this study was to explore outcomes in a cohort of dcSSc patients fulfilling eligibility criteria for stem cell transplantation (SCT) studies but receiving standard immunosuppression. Methods From a large single-centre…
View article: P154 High-density proteomic analysis of skin blister fluid and plasma in systemic sclerosis identifies local and systemic differences for key proteins
P154 High-density proteomic analysis of skin blister fluid and plasma in systemic sclerosis identifies local and systemic differences for key proteins Open
Background/Aims Simultaneous analysis of multiple proteins in biological fluids offers insight into the pathogenesis of SSc. Here, we report a proteomic analysis of plasma and dermal interstitial fluid in SSc compared with healthy controls…
View article: O18 Integrated molecular analysis of systemic sclerosis skin and blood shows significant differences between major autoantibody subgroups
O18 Integrated molecular analysis of systemic sclerosis skin and blood shows significant differences between major autoantibody subgroups Open
Background/Aims The major antinuclear autoantibodies of systemic sclerosis (SSc) associate with different skin score trajectories and risk of internal organ manifestations. To elucidate molecular differences between ANA-defined subgroups, …
View article: P152 Skin score trajectory associates with survival and pulmonary outcome in diffuse cutaneous systemic sclerosis
P152 Skin score trajectory associates with survival and pulmonary outcome in diffuse cutaneous systemic sclerosis Open
Background Skin thickness improves over time in most diffuse cutaneous systemic sclerosis (dcSSc) patients and the use of group level skin score (mRss) as an endpoint is clinical trials can be challenging. We explore the association betwee…
View article: P151 Forced vital capacity in patients with systemic sclerosis associated pulmonary fibrosis: predictors of meaningful decline
P151 Forced vital capacity in patients with systemic sclerosis associated pulmonary fibrosis: predictors of meaningful decline Open
Background Pulmonary fibrosis (PF) is common in systemic sclerosis (SSc) and serial pulmonary function tests (PFTs) are used for routine PF monitoring. Forced vital capacity (FVC) decline reflects progression in PF and FVC is frequently us…
View article: P154 Stage and subset specific profiles of fibrogenesis highlighted through analysis of serum markers across the scleroderma spectrum
P154 Stage and subset specific profiles of fibrogenesis highlighted through analysis of serum markers across the scleroderma spectrum Open
Background The striking heterogeneity in skin fibrosis within systemic sclerosis (SSc) is likely to reflect differences between pro- and anti-fibrotic pathways and underlie the spontaneous regression of skin fibrosis observed in late stage…
View article: Prospects for Stratified and Precision Medicine in Systemic Sclerosis Treatment
Prospects for Stratified and Precision Medicine in Systemic Sclerosis Treatment Open
Precision medicine is an evolving field stemming from Oncology research, with an increasingly important role in autoimmune diseases. The heterogeneity, both of clinical presentations of systemic sclerosis and differing response to treatmen…
View article: What does it mean if a patient is positive for anti-Jo-1 in routine hospital practice? A retrospective nested case-control study
What does it mean if a patient is positive for anti-Jo-1 in routine hospital practice? A retrospective nested case-control study Open
Background: It is widely believed that patients bearing auto-antibodies to histidyl tRNA synthetase (anti-Jo-1) very likely have a connective tissue disease including myositis and interstitial lung disease. The value of positive tests in l…
View article: Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature
Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature Open
Our study suggests the presence of molecular subsets in lcSSc based on gene expression profiling of biopsies from uninvolved skin. This may reflect important differences in pathogenesis within these patient groups. We identify differential…