Emma J. Keller
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View article: B cell intrinsic TLR3 and TLR7 signaling synergistically enhance B cell differentiation during influenza infection-induced extrafollicular responses 3781
B cell intrinsic TLR3 and TLR7 signaling synergistically enhance B cell differentiation during influenza infection-induced extrafollicular responses 3781 Open
Description The extrafollicular (EF) B cell response induces virus-neutralizing, class switched antibodies rapid enough to impact influenza virus clearance after acute infection. Previously we showed that MyD88 and TRIF are both required f…
View article: Real-life observation of wildfire-smoke impaired COVID-19 vaccine immunity
Real-life observation of wildfire-smoke impaired COVID-19 vaccine immunity Open
Background: Wildfires are increasingly common with wildfire smoke affecting millions globally, yet its impact on immune responses is poorly understood. Natural Killer (NK) cells play a role in mediating air pollutant effects and regulating…
View article: TLR3 Signaling is Required for Robust Extrafollicular B Cell Response (EF) in Influenza A/PR/8 Infection
TLR3 Signaling is Required for Robust Extrafollicular B Cell Response (EF) in Influenza A/PR/8 Infection Open
Following influenza A virus (IAV) infection B cells rapidly proliferate and differentiate into plasma cells (PCs) in extrafollicular foci (EF) within mediastinal lymph nodes (medLN), resulting in protective antibody secretion. We had shown…
View article: Spontaneous CD4+ T Cell Activation and Differentiation in Lupus-Prone B6.Nba2 Mice Is IFNAR-Independent
Spontaneous CD4+ T Cell Activation and Differentiation in Lupus-Prone B6.Nba2 Mice Is IFNAR-Independent Open
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by dysregulated T and B lymphocytes. Type I interferons (IFN-I) have been shown to play important pathogenic roles in both SLE patients and mouse models of lupus. R…
View article: S100a9 Protects Male Lupus-Prone NZBWF1 Mice From Disease Development
S100a9 Protects Male Lupus-Prone NZBWF1 Mice From Disease Development Open
Systemic lupus erythematosus (SLE) is an autoimmune disorder disproportionally affecting women. A similar sex difference exists in the murine New Zealand Black/White hybrid model (NZBWF1) of SLE with all females, but only 30-40% of males, …
View article: Partial Protection From Lupus-Like Disease by B-Cell Specific Type I Interferon Receptor Deficiency
Partial Protection From Lupus-Like Disease by B-Cell Specific Type I Interferon Receptor Deficiency Open
Systemic lupus erythematosus (SLE) is an autoimmune disease that can present with many different permutations of symptom presentation. A large subset of SLE patients have been shown to present with elevated interferon stimulated gene (ISG)…
View article: Low Levels of Vitamin D Promote Memory B Cells in Lupus
Low Levels of Vitamin D Promote Memory B Cells in Lupus Open
Background: Vitamin D deficiency is a known risk factor for Systemic Lupus Erythematosus (SLE), yet clinical trials have not demonstrated efficacy and few studies have utilized lupus models to understand the mechanism underlying this relat…
View article: 249 Splenomegaly and anti-nuclear antibodies are driven by interferon- stimulation of B cells in lupus-like disease
249 Splenomegaly and anti-nuclear antibodies are driven by interferon- stimulation of B cells in lupus-like disease Open
Background Systemic Lupus Erythematous (SLE) is an autoimmune disease of unknown etiology affecting 5 million people worldwide. It is known that 50%–70% of lupus patients present with an interferon-alpha (IFN-) gene signature, and it has b…